ChemicalBook > CAS DataBase List > METHYL 2-FLUORO-6-HYDROXYBENZOATE

METHYL 2-FLUORO-6-HYDROXYBENZOATE

Product Name
METHYL 2-FLUORO-6-HYDROXYBENZOATE
CAS No.
72373-81-0
Chemical Name
METHYL 2-FLUORO-6-HYDROXYBENZOATE
Synonyms
RARECHEM AL BF 1190;METHYL 6-FLUOROSALICYLATE;METHYL 6-FLUORO-2-HYDROXYBENZOATE;METHYL 2-FLUORO-6-HYDROXYBENZOATE;2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER;BENZOIC ACID,2-FLUORO-6-HYDROXY-, METHYL ESTER;METHYL 2-FLUORO-6-HYDROXYBENZOATE ISO 9001：2015 REACH;Methyl 6-fluorosalicylate, 3-Fluoro-2-(methoxycarbonyl)phenol
CBNumber
CB8229548
Molecular Formula
C8H7FO3
Formula Weight
170.14
MOL File
72373-81-0.mol
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METHYL 2-FLUORO-6-HYDROXYBENZOATE Property

Melting point:
71°C
Boiling point:
65-70°C 1,7mm
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
8.76±0.10(Predicted)
form 
liquid
color 
Clear, colourless
CAS DataBase Reference
72373-81-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M305495
Product name
Methyl2-fluoro-6-hydroxybenzoate
Packaging
500mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
2629-3-06
Product name
Methyl 2-fluoro-6-hydroxybenzoate
Purity
98%
Packaging
1g
Price
$85
Updated
2021/12/16
Oakwood
Product number
006803
Product name
Methyl6-fluorosalicylate
Purity
98%
Packaging
1g
Price
$52
Updated
2021/12/16
AK Scientific
Product number
J94949
Product name
Methyl2-fluoro-6-hydroxybenzoate
Packaging
1g
Price
$54
Updated
2021/12/16
Matrix Scientific
Product number
003820
Product name
Methyl 6-fluorosalicylate
Purity
98%
Packaging
1g
Price
$59
Updated
2021/12/16
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METHYL 2-FLUORO-6-HYDROXYBENZOATE Chemical Properties,Usage,Production

Synthesis

67-56-1

67531-86-6

72373-81-0

Procedure for the synthesis of methyl 2-fluoro-6-hydroxybenzoate (2): 2-fluoro-6-hydroxybenzoic acid (Oakwood Products; 0.972 kg, 6.31 mol), methanol (7.60 L), and sulfuric acid (0.710 kg, 7.24 mol, 1.15 eq.) were added to a 20 L jacketed reactor. The jacket temperature was raised to 60°C and the reaction mixture was stirred continuously for 45 hours. Upon completion of the reaction, about 7.5 L of methanol distillate was removed by vacuum concentration. The residue was cooled to 20 °C and extracted by adding water (7.60 L) and ethyl acetate (7.60 L) to transfer the product to the organic layer. The ethyl acetate layer was washed sequentially with aqueous sodium bicarbonate (1.52 Kg sodium bicarbonate dissolved in 6.92 L water) and aqueous sodium chloride (1.74 kg sodium chloride dissolved in 4.08 L water). The washed ethyl acetate solution was concentrated to dryness to give a light orange colored oily substance. After standing, the oily material gradually crystallized to give the target product methyl 2-fluoro-6-hydroxybenzoate (2) (0.952 Kg, 5.60 mol, 89% yield). The product was analyzed by 1H NMR, 13C NMR and mass spectrometry to confirm the structure.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 2, p. 233 - 241
[2] Patent: WO2011/101774, 2011, A1. Location in patent: Page/Page column 25-26
[3] Acta Chemica Scandinavica, 1997, vol. 51, # 8, p. 881 - 888

METHYL 2-FLUORO-6-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-FLUORO-6-HYDROXYBENZOATE Suppliers

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72373-81-0, METHYL 2-FLUORO-6-HYDROXYBENZOATERelated Search:

Methyl 4-fluoro-3-hydroxybenzoate, 98+%,METHYL 4-FLUORO-3-HYDROXYBENZOATE Methyl 4-fluoro-2-hydroxybenzoate 98%,METHYL 4-FLUORO-2-HYDROXYBENZOATE,Methyl4-fluoro-2-hydroxybenzoate98% METHYL 3-FLUORO-4-HYDROXYBENZOATE METHYL 5-FLUORO-2-HYDROXYBENZOATE METHYL 3,6-DIFLUORO-2-HYDROXYBENZOATE 2,4-DIFLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER METHYL 2-FLUORO-6-HYDROXYBENZOATE METHYL 2-FLUORO-6-METHOXYBENZOATE METHYL 2-FLUORO-4-HYDROXYBENZOATE METHYL 3-FLUORO-2-HYDROXYBENZOATE Methyl 2-fluoro-6-hydroxybenzoate 98% RARECHEM AL BI 1190 RARECHEM AL BF 1275 RARECHEM AL BI 1275 2,3-DIFLUORO-6-HYDROXYBENZOIC ACID ETHYL ESTER 2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-6-FLUOROBENZOIC ACID, METHYL ESTER RARECHEM AL BI 0857 RARECHEM AL BI 0526

  • RARECHEM AL BF 1190
  • METHYL 2-FLUORO-6-HYDROXYBENZOATE
  • METHYL 6-FLUORO-2-HYDROXYBENZOATE
  • METHYL 6-FLUOROSALICYLATE
  • 2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER
  • Methyl 6-fluorosalicylate, 3-Fluoro-2-(methoxycarbonyl)phenol
  • BENZOIC ACID,2-FLUORO-6-HYDROXY-, METHYL ESTER
  • METHYL 2-FLUORO-6-HYDROXYBENZOATE ISO 9001：2015 REACH
  • 72373-81-0
  • Benzoic acid