METHYL 2-FLUORO-6-HYDROXYBENZOATE
- Product Name
- METHYL 2-FLUORO-6-HYDROXYBENZOATE
- CAS No.
- 72373-81-0
- Chemical Name
- METHYL 2-FLUORO-6-HYDROXYBENZOATE
- Synonyms
- RARECHEM AL BF 1190;METHYL 6-FLUOROSALICYLATE;METHYL 6-FLUORO-2-HYDROXYBENZOATE;METHYL 2-FLUORO-6-HYDROXYBENZOATE;2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER;BENZOIC ACID,2-FLUORO-6-HYDROXY-, METHYL ESTER;METHYL 2-FLUORO-6-HYDROXYBENZOATE ISO 9001：2015 REACH;Methyl 6-fluorosalicylate, 3-Fluoro-2-(methoxycarbonyl)phenol
- CBNumber
- CB8229548
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 72373-81-0.mol
METHYL 2-FLUORO-6-HYDROXYBENZOATE Property
- Melting point:
- 71°C
- Boiling point:
- 65-70°C 1,7mm
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 8.76±0.10(Predicted)
- form
- liquid
- color
- Clear, colourless
- CAS DataBase Reference
- 72373-81-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M305495
- Product name
- Methyl2-fluoro-6-hydroxybenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 006803
- Product name
- Methyl6-fluorosalicylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 006803
- Product name
- Methyl6-fluorosalicylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- J94949
- Product name
- Methyl2-fluoro-6-hydroxybenzoate
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- 003820
- Product name
- Methyl 6-fluorosalicylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
METHYL 2-FLUORO-6-HYDROXYBENZOATE Chemical Properties,Usage,Production
Synthesis
67-56-1
67531-86-6
72373-81-0
Procedure for the synthesis of methyl 2-fluoro-6-hydroxybenzoate (2): 2-fluoro-6-hydroxybenzoic acid (Oakwood Products; 0.972 kg, 6.31 mol), methanol (7.60 L), and sulfuric acid (0.710 kg, 7.24 mol, 1.15 eq.) were added to a 20 L jacketed reactor. The jacket temperature was raised to 60°C and the reaction mixture was stirred continuously for 45 hours. Upon completion of the reaction, about 7.5 L of methanol distillate was removed by vacuum concentration. The residue was cooled to 20 °C and extracted by adding water (7.60 L) and ethyl acetate (7.60 L) to transfer the product to the organic layer. The ethyl acetate layer was washed sequentially with aqueous sodium bicarbonate (1.52 Kg sodium bicarbonate dissolved in 6.92 L water) and aqueous sodium chloride (1.74 kg sodium chloride dissolved in 4.08 L water). The washed ethyl acetate solution was concentrated to dryness to give a light orange colored oily substance. After standing, the oily material gradually crystallized to give the target product methyl 2-fluoro-6-hydroxybenzoate (2) (0.952 Kg, 5.60 mol, 89% yield). The product was analyzed by 1H NMR, 13C NMR and mass spectrometry to confirm the structure.
References
[1] Organic Process Research and Development, 2016, vol. 20, # 2, p. 233 - 241
[2] Patent: WO2011/101774, 2011, A1. Location in patent: Page/Page column 25-26
[3] Acta Chemica Scandinavica, 1997, vol. 51, # 8, p. 881 - 888
METHYL 2-FLUORO-6-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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