ChemicalBook > CAS DataBase List > 3,4,5-Trimethoxytoluene

3,4,5-Trimethoxytoluene

Product Name
3,4,5-Trimethoxytoluene
CAS No.
6443-69-2
Chemical Name
3,4,5-Trimethoxytoluene
Synonyms
TriMethoxytoluene;3,4,5-Trimethoxytolu;Trimethoprim Lactnte;3,4,5-trimethoxytoluen;3,4,5-Trimethoxytolune;3,4,5-TRIMETHOXYTOLUENE;Toluene, 3,4,5-trimethoxy-;3,4,5-Trimethoxytoluene,97%;5-Methyl-1,2,3-trimethoxybenzene;1,2,3-Trimethoxy-5-methylbenzene
CBNumber
CB8232173
Molecular Formula
C10H14O3
Formula Weight
182.22
MOL File
6443-69-2.mol
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3,4,5-Trimethoxytoluene Property

Melting point:
24-26 °C (lit.)
Boiling point:
117-118 °C/5 mmHg (lit.)
Density 
1.082 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.523(lit.)
Flash point:
166 °F
storage temp. 
Sealed in dry,Room Temperature
form 
powder to lump to clear liquid
color 
White or Colorless to Light yellow
Specific Gravity
1.082
BRN 
1953791
LogP
1.819 (est)
CAS DataBase Reference
6443-69-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1,2,3-trimethoxy-5-methyl-(6443-69-2)
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Safety

Hazard Codes 
Xi
Safety Statements 
23-24/25
WGK Germany 
3
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
227714
Product name
3,4,5-Trimethoxytoluene
Purity
97%
Packaging
10g
Price
$45.85
Updated
2025/07/31
TCI Chemical
Product number
T1236
Product name
3,4,5-Trimethoxytoluene
Purity
>98.0%(GC)
Packaging
25g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
T1236
Product name
3,4,5-Trimethoxytoluene
Purity
>98.0%(GC)
Packaging
500g
Price
$262
Updated
2023/06/20
TRC
Product number
T796245
Product name
3,4,5-Trimethoxytoluene
Packaging
1g
Price
$50
Updated
2021/12/16
AK Scientific
Product number
J56015
Product name
3,4,5-Trimethoxytoluene
Packaging
25g
Price
$29
Updated
2021/12/16
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3,4,5-Trimethoxytoluene Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

3,4,5-Trimethoxytoluene is a reagent for oxadiazolylindazole sodium channel modulators which are neuroprotective toward hippocampal neurons.

Uses

3,4,5-Trimethoxytoluene was used as a substructure model compound in the reaction of trimethoprim with free available chlorine (i.e. HOCl).

Definition

ChEBI: 3,4,5-Trimethoxytoluene is a member of methoxybenzenes.

Synthesis

86-81-7

6443-69-2

Using 3,4,5-trimethoxybenzaldehyde as the starting material, referring to the synthesis method of Example 2, 10 g of 3,4,5-trimethoxybenzaldehyde was dissolved in 100 g of tetrahydrofuran, 1 g of Catalyst B was added, and the hydrogenation reaction was carried out under hydrogen atmosphere. Upon completion of the reaction, the aldehyde group conversion was confirmed to be 100% by testing. The isolated yield of the target product 3,4,5-trimethoxytoluene was 96% based on the initial addition of 3,4,5-trimethoxybenzaldehyde.

References

[1] Bioorganic Chemistry, 2016, vol. 68, p. 214 - 218
[2] Tetrahedron, 2007, vol. 63, # 38, p. 9382 - 9386
[3] Synthesis, 1993, # 8, p. 797 - 802
[4] Synthetic Communications, 2006, vol. 36, # 14, p. 1961 - 1965
[5] Journal of Chemical Research, 2010, vol. 34, # 12, p. 717 - 718

3,4,5-Trimethoxytoluene Preparation Products And Raw materials

Raw materials

Preparation Products

Idebenone
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3,4,5-Trimethoxytoluene Suppliers

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View Lastest Price from 3,4,5-Trimethoxytoluene manufacturers

Henan Fengda Chemical Co., Ltd
Product
3,4,5-Trimethoxytoluene 6443-69-2
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
3,4,5-Trimethoxytoluene 6443-69-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3,4,5-Trimethoxytoluene 6443-69-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

6443-69-2, 3,4,5-TrimethoxytolueneRelated Search:

Benzotrifluoride Mesitylene (Trifluoromethoxy)benzene Trimethyl phosphite Trimethoxymethane Anisole 4-(Trifluoromethoxy)aniline 1,2,4-Trimethylbenzene Colchicine 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetonitrile 3,4,5-Trimethoxybenzoyl chloride 3,4,5-TRIMETHOXYCINNAMIC ACID 3,4,5-Trimethoxybenzonitrile 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3,4,5-Trimethoxybenzyl alcohol Methyl 3,4,5-trimethoxybenzoate 2,4,6-Trinitrotoluene

  • 1,2,3-Trimethoxy-5-methylbenzene
  • 5-Methyl-1,2,3-trimethoxybenzene
  • Benzene, 5-methyl-1,2,3-trimethoxy
  • Toluene, 3,4,5-trimethoxy-
  • 5-METHYL PYROGALLOL TRIMETHYL ETHER
  • 3,4,5-TRIMETHOXYTOLUENE
  • 3,4,5-Trimethoxytolu
  • 3,4,5-Trimethoxytolune
  • 3,4,5-trimethoxytoluen
  • Benzene, 1,2,3-trimethoxy-5-methyl-
  • 3,4,5-Trimethoxytoluene,97%
  • 3-(3,4-dimethoxyphenyl)-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine hydrochloride
  • TriMethoxytoluene
  • 3,4,5-Trimethoxytoluene ISO 9001：2015 REACH
  • 3,4,5-Trimethoxytoluene 6443-69-2
  • Trimethoprim Lactnte
  • 3,4,5-Trimethoxytoluene, ≥ 98.0%
  • 1,2,3-Trimethoxy-5-methylbenzene - [T94157]
  • 6443-69-2
  • Building Blocks
  • Organic Building Blocks
  • Ethers
  • Oxygen Compounds
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Anisoles, Alkyloxy Compounds & Phenylacetates