Bucladesine sodium

Product Name: Bucladesine sodium
CAS No.: 16980-89-5
Chemical Name: Bucladesine sodium
Synonyms: DC 2797;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;bucladesinesodium
CBNumber: CB8236166
Molecular Formula: C18H25N5NaO8P
Formula Weight: 493.39
MOL File: 16980-89-5.mol

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Bucladesine sodium Property

Melting point:: >173°C (dec.)
storage temp.: -20°C
solubility: H₂O: 50 mg/mL
form: powder
color: white
Merck: 14,1463
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey: DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES: O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|

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Safety

Safety Statements: 24/25
WGK Germany: 2
RTECS: ES5055500
F: 10-21
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 25mg
Price: $136
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 100mg
Price: $418
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3′,5′-cyclic Monophosphate, N⁶,O<sup>2′</sup>-Dibutyryl-, Sodium Salt
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 1g
Price: $1250
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 28745-1GM
Price: $1220
Updated: 2023/06/20

TCI Chemical

Product number: D4228
Product name: N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $121
Updated: 2024/03/01

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Bucladesine sodium Chemical Properties,Usage,Production

Description

Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.

Originator

Daiichi Seiyaku; Seishin Seiyaku (Japan)

Uses

Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.

Definition

ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.

Application

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation

brand name

ACTOCIN

General Description

A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

storage

Store at -20°C

References

1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270

Bucladesine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bucladesine sodium manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Bucladesine sodium salt；dc2797 , sodium dibutyryl camp , dibutyryl-camp sodium salt , dbcamp 16980-89-5
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 90.0%Min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-09

Hebei Yanxi Chemical Co., Ltd.

Product: Bucladesine 16980-89-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-14

Hebei Weibang Biotechnology Co., Ltd

Product: Bucladesine 16980-89-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

16980-89-5, Bucladesine sodiumRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt NAD+ 8-CHLORO-CAMP 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Bucladesine (calciuM salt) 6-MB-CAMP SODIUM SALT 2'-O-MB-CAMP SODIUM SALT SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Butyramide Cyclic AMP Bucladesine

dibutylcyclicampsodium

dibutylcyclicampsodiumsalt

dt5621sodiumsalt

e,butyrate(ester),monosodiumsalt

monosodiumdibutyrylcyclicamp

n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat

n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt

n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt

N,2'-O-Dibutanoyladenosine 3',5'-(phosphoric acid sodium) salt

N,2'-O-Dibutyryladenosine-3',5'-phosphoric acid sodium salt

Sodium bucladesine

,5&Otilde

-cyclophosphate sodium salt monohydrate

N6-2&Otilde

-O-Dibutyryl-adenosine 3&Otilde

Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt

Calcium Dibutyacyladenosine Cyclophosphate

N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHA

N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLO-P HOSPHATE SO-SALT

Dibutyacyladenosine

4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.

Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt (8CI)

DC 2797

Dibutyryl 3',5'-cyclic AMP sodium salt

Dibutyryl cyclic AMP monosodium salt

Dibutyryl cyclic AMP sodium

N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt

N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt

N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt

N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt

Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate

DIBUTYRYL-CYCLICAMP

BUCLADESINE[N-6,O-2''-DIBUTYRYL ADENOSINE CYCLIC 3'',5''-MONOPHOSPHATE]

N6,2'-O-DIBUTRYL-ADENISINE-3',5'-CYCLICMONPHOSPHATE SODIUM SALT

Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt

Bucladesine, Dibutyryl cyclic-AMP

N6,2μ-O-Dibutyryladenosine 3μ,5μ-cyclic monophosphate monohydrate sodium salt

ibutyryl cyclic AMP sodium

N6,O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE NA

Dibutyacyladenosine cyclphosphate

Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodiuM salt(1:1)

Adenosine 3?,5?-cyclic Monophosphate, N?,O

Dibutyryl-cAMP sodium salt, >=98%

adenosine,n-(1-oxobutyl)-,cyclic3’,5’-(hydrogenphosphate)-2’-butanoate,m

bucladesinesodium

butyramide,n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-,cyclichydrogenphosphate,butyrate(ester),monosodiumsalt

dibutylcampsodiumsalt

sodiumdibutyryl3’,5’-cyclicamp

sodiumdibutyrylcamp

N6, O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE SODIUM SALT

N6,O2'-DIBUTYRYL ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,O2'-DIBUTYRYLADENOSINE-3':5'-PHOSPHATE CYCLIC NA-SALT

N6,O2'-DIBUTYRYLADENOSINE-3',5'-PHOSPHATE CYCLIC SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID, SODIUM

ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, N6,O2'-DIBUTYRYL-, SODIUM SALT

ADENOSINE-3',5'-CYCLIC MONOPHOSPHORIC ACID, N,2'O-DIBUTYRYL, SODIUM SALT