ChemicalBook > CAS DataBase List > 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

Product Name
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
CAS No.
85547-22-4
Chemical Name
8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
Synonyms
Apatamine;AAPTAMINE;6]naphtyridine;9-Dimethoxy-1H-benzo[de][1;8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE;6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(;8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE;1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
CBNumber
CB8243320
Molecular Formula
C13H12N2O2
Formula Weight
228.25
MOL File
85547-22-4.mol
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8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Property

storage temp. 
4°C, protect from light
solubility 
DMSO: soluble,Ethanol: soluble
form 
Solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24297
Product name
Aaptamine
Packaging
1mg
Price
$283
Updated
2021/12/16
Cayman Chemical
Product number
24297
Product name
Aaptamine
Packaging
500μg
Price
$149
Updated
2021/12/16
TRC
Product number
A164268
Product name
Aaptamine
Packaging
1mg
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-0032464
Product name
Aaptamine
Purity
≥98.0%
Packaging
1mg
Price
$305
Updated
2021/12/16
AK Scientific
Product number
8722CA
Product name
Aaptamine
Packaging
1mg
Price
$482
Updated
2021/12/16
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8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

Aaptamine is a spongean alkaloid that can activate the p21 promoter in the absence of p53 and can function as a proteasome inhibitor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 616, 1987 DOI: 10.1021/jo00380a024
Tetrahedron Letters, 31, p. 569, 1990 DOI: 10.1016/0040-4039(90)87037-Z

in vivo

Aaptamine (5-100 μg; intrathecal injection; single dose) has an analgesic effect in a rat model of chronic constriction injury (CCI)-induced peripheral neuropathy[7].

Animal Model:Chronic constriction injury treated adult male Wistar rats (250-285 g)[7]
Dosage:5, 30 and 100 μg
Administration:Intrathecal injection; single dose
Result:Showed different durations of analgesic effects on CCI-induced nociception. The 5 μg, 30 μg, and 100 μg doses presented analgesic durations of 90, 150, and 150 minutes respectively. However, the variance in the group administered with 100 μg of aaptamine was the largest, and the rats presented some abnormal motor behavior.

IC 50

AChE: 0.23 μg/mL (IC50); BChE: 1.38 μg/mL (IC50)

8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE Suppliers

China 50 Switzerland 1 United States 7 Global 58
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85547-22-4, 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINERelated Search:

Cevadine veratramine Xanthiside daurisoline VERATRIDINE 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one L-Hyoscyamine Xanthiazone Daurinoline menisdaurin 8-Aminoisoquinoline 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE

  • 6)naphthyridine,8,9-dimethoxy-1h-benzo(de)(
  • AAPTAMINE
  • 8,9-DIMETHOXY-1H-BENZO[DE][1,6]NAPHTHYRIDINE
  • Apatamine
  • 6]naphtyridine
  • 8;9-DIMETHOXY-1H-BENZO[DE][1;6]NAPHTYRIDINE
  • 9-Dimethoxy-1H-benzo[de][1
  • 1H-Benzo[de][1,6]naphthyridine, 8,9-dimethoxy-
  • 85547-22-4