ChemicalBook > CAS DataBase List > Vantas

Vantas

Product Name: Vantas
CAS No.: 220810-26-4
Chemical Name: Vantas
Synonyms: Vantas;Supprelin la;Vantas USP/EP/BP;Histrelin acetate, >=98%;Histrelin?Acetate impurity;Histrelin Acetate(acetate);(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate;(Des-Gly??,D-His(Bzl)?,Pro-NHEt?)-LHRH acetate salt;(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
CBNumber: CB82493747
Molecular Formula: C66H86N18O12
Formula Weight: 1323.52
MOL File: 220810-26-4.mol

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Vantas Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to off-white
Sequence: {Pyr}-His-Trp-Ser-Tyr-{d-His(Bzl)}-Leu-Arg-Pro-{NHEt}

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23663
Product name: Histrelin (acetate)
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 23663
Product name: Histrelin (acetate)
Purity: ≥98%
Packaging: 5mg
Price: $360
Updated: 2024/03/01

Cayman Chemical

Product number: 23663
Product name: Histrelin (acetate)
Purity: ≥98%
Packaging: 10mg
Price: $625
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD110400
Product name: (Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
Packaging: 1mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD110400
Product name: (Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
Packaging: 2mg
Price: $100
Updated: 2021/12/16

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Vantas Chemical Properties,Usage,Production

Description

Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; K_i = 0.2 nM in CHO cells expressing the human receptor). It stimulates release of oxytocin and vasopressin ex vivo from the isolated rat hypothalamo-neurohypophysial system at a concentration of 100 nM. In vivo, the initial dose of histrelin (100 μg) stimulates acute increases in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone serum levels (50-, 2.5-, and 15-fold, respectively), while chronic treatment leads to 95% decreases in LH and FSH responses in rhesus monkeys. Formulations containing histrelin have been used in the treatment of advanced prostate cancer and central precocious puberty.

Uses

Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis[1][2][5].

Definition

ChEBI: An acetate salt obtained by combining histrelin with acetic acid. The amount of acetic acid present can vary and a variable amount of water may be present. Histrelin acetate is used as a subcutaneous hydrogel implant for the treatment of prostate cancer an for the suppression of gonadal sex hormone production in children with central precocious puberty.

in vivo

Histrelin (0.1 mg/kg, subcutaneous injection) acetate rescues the circulating LH concentrations in Csfm^op/Csfm^op mice^[2].
Histrelin (10,30, or 100 μg /day, subcutaneous injection) acetate reduces the number of endometrial glands and atrophied the stroma in rabbits^[3].

References

[1] Emma D Deeks, et al. Histrelin: in advanced prostate cancer. Drugs. 2010 Mar 26;70(5):623-30. DOI:10.2165/11204800-000000000-00000
[2] Marlena Juszczak, et al. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res Bull. 2010 Jan 15;81(1):185-90. DOI:10.1016/j.brainresbull.2009.10.012
[3] P E Cohen, et al. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Mol Endocrinol. 1997 Oct;11(11):1636-50. DOI:10.1210/mend.11.11.0009
[4] D W Hahn, et al. Development of an animal model for quantitatively evaluating effects of drugs on endometriosis. Fertil Steril. 1985 Sep;44(3):410-5. DOI:10.1016/s0015-0282(16)48869-2
[5] E Boczek-Leszczyk, et al. Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone (GnRH), its analogues and melatonin. J Physiol Pharmacol. 2010 Aug;61(4):459-66. PMID:20814074

Vantas Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vantas manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Vantas 220810-26-4
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Vantas;Histrelin acetate 220810-26-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: Vantas 220810-26-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate salt Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt

Supprelin la

Vantas

Histrelin acetate, >=98%

Histrelin?Acetate impurity

Vantas USP/EP/BP

Histrelin Acetate(acetate)

(Des-Gly??,D-His(Bzl)?,Pro-NHEt?)-LHRH acetate salt

(Des-Gly10,D-His(Bzl)6,Pro-NHEt 9)-LHRH acetate

220810-26-4

C66H86N18O12xC2H4O2

C70H94N18O16