ChemicalBook > CAS DataBase List > xav-939

xav-939

Product Name
xav-939
CAS No.
284028-89-3
Chemical Name
xav-939
Synonyms
XAV d;CS-300;xav-939;NVP-XAV 939;SteMolecule;XAV 939, >=98%;XAV-939;XAV 939;xav-939 USP/EP/BP;XAV 939/NVP-XAV939;XAV-939 284028-89-3
CBNumber
CB82501008
Molecular Formula
C14H11F3N2OS
Formula Weight
312.31
MOL File
284028-89-3.mol
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xav-939 Property

Boiling point:
429.3±55.0 °C(Predicted)
Density 
1.5
Flash point:
213.4℃
storage temp. 
room temp
solubility 
DMSO: soluble5mg/mL, clear
form 
powder
pka
0.23±0.20(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45-26/45
RIDADR 
UN 2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
X3004
Product name
XAV 939
Purity
≥98% (HPLC)
Packaging
5mg
Price
$86
Updated
2024/03/01
Sigma-Aldrich
Product number
X3004
Product name
XAV 939
Purity
≥98% (HPLC)
Packaging
25mg
Price
$347
Updated
2024/03/01
TCI Chemical
Product number
X0077
Product name
XAV 939
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$127
Updated
2024/03/01
TCI Chemical
Product number
X0077
Product name
XAV 939
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$572
Updated
2023/01/07
Cayman Chemical
Product number
13596
Product name
XAV 939
Purity
≥98%
Packaging
1mg
Price
$15
Updated
2024/03/01
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xav-939 Chemical Properties,Usage,Production

Description

XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).? Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1? XAV-939 robustly induces cardiomyogenesis of stem cells.2? Cell permeable

Uses

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Uses

XAV939 has been used in the inhibition

  • of tankyrase in neuroblastoma cell lines
  • of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
  • of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Definition

ChEBI: XAV939 is a thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. It has a role as a tankyrase inhibitor. It is a thiopyranopyrimidine and a member of (trifluoromethyl)benzenes.

Biochem/physiol Actions

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

storage

Room temperature

References

1) Huang?et al. (2009),?Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Nature,?46?614 2) Wang?et al. (2011),?Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling; Chem. Biol.,?6?192

xav-939 Preparation Products And Raw materials

Raw materials

Preparation Products

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xav-939 Suppliers

Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

284028-89-3, xav-939Related Search:


  • xav-939
  • 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
  • XAV 939/NVP-XAV939
  • CS-300
  • 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
  • XAV 939, >=98%
  • SteMolecule
  • 1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
  • NVP-XAV 939
  • 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
  • XAV 939 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
  • 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
  • XAV-939;XAV 939
  • 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
  • XAV-939, 98%, a selective Wnt pathway β-catenin-mediated transcription inhibitor
  • XAV d
  • 4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-
  • xav-939 USP/EP/BP
  • 2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one
  • XAV-939 284028-89-3
  • poly ADP ribose polymerase,PARP,Inhibitor,β-catenin,inhibit,Beta catenin,XAV-939,XAV 939
  • 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one
  • 284028-89-3
  • C14H11F3N2OS
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • API
  • Aromatics