ChemicalBook > CAS DataBase List > 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Product Name
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
CAS No.
147591-46-6
Chemical Name
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Synonyms
ID 8;CS-989;ID 8; ID8;ID 8 free base;1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol;1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-;1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8;cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase
CBNumber
CB82510019
Molecular Formula
C16H14N2O4
Formula Weight
298.29
MOL File
147591-46-6.mol
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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Property

Melting point:
266 °C(dec.)
storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
WGK Germany 
3
HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I1786
Product name
ID 8
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
I1786
Product name
ID 8
Purity
≥98% (HPLC)
Packaging
25mg
Price
$379
Updated
2024/03/01
TCI Chemical
Product number
I1108
Product name
ID 8
Packaging
10MG
Price
$123
Updated
2024/03/01
TCI Chemical
Product number
I1108
Product name
ID 8
Packaging
50MG
Price
$425
Updated
2024/03/01
Cayman Chemical
Product number
15222
Product name
ID 8
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties,Usage,Production

Description

ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2

Uses

ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.

General Description

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem/physiol Actions

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

storage

+4°C

References

1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Suppliers

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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3bsc@sina.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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Haoyuan Chemexpress Co., Ltd.
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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Sales-JP@TCIchemicals.com
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Japan
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TCI Europe
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+32 (0)37350701
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sales@tcieurope.eu
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Europe
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TCI AMERICA
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+1-888-520-1075 / +1-503-283-1987
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MedChemexpress LLC
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AdooQ BioScience, LLC
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147591-46-6, 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-olRelated Search:


  • 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
  • ID 8
  • 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8
  • ID 8; ID8
  • CS-989
  • 1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol
  • ID 8 free base
  • 1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-
  • 1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
  • cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase
  • 147591-46-6
  • Inhibitors