1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- Product Name
- 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- CAS No.
- 147591-46-6
- Chemical Name
- 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- Synonyms
- ID 8;CS-989;ID 8; ID8;ID 8 free base;1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol;1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-;1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8;cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase
- CBNumber
- CB82510019
- Molecular Formula
- C16H14N2O4
- Formula Weight
- 298.29
- MOL File
- 147591-46-6.mol
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Property
- Melting point:
- 266 °C(dec.)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- powder
- color
- yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I1786
- Product name
- ID 8
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- I1786
- Product name
- ID 8
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $379
- Updated
- 2024/03/01
- Product number
- I1108
- Product name
- ID 8
- Packaging
- 10MG
- Price
- $123
- Updated
- 2024/03/01
- Product number
- I1108
- Product name
- ID 8
- Packaging
- 50MG
- Price
- $425
- Updated
- 2024/03/01
- Product number
- 15222
- Product name
- ID 8
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties,Usage,Production
Description
ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2
Uses
ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.
General Description
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Biochem/physiol Actions
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
storage
+4°C
References
1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Suppliers
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