2,5-Di-tert-butylhydroquinone
- Product Name
- 2,5-Di-tert-butylhydroquinone
- CAS No.
- 88-58-4
- Chemical Name
- 2,5-Di-tert-butylhydroquinone
- Synonyms
- BHQ;dtbhq;DBHQ;Probes;ANTIOXIDANT DTBHQ;Dibutylhydroquinone;Black Hole Quencher;2,5-ditertiary butyl hydroquinone;2-carbamoyl-2-propylpentanoic acid;2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE
- CBNumber
- CB8258782
- Molecular Formula
- C14H22O2
- Formula Weight
- 222.32
- MOL File
- 88-58-4.mol
2,5-Di-tert-butylhydroquinone Property
- Melting point:
- 216-218 °C(lit.)
- Boiling point:
- 321°C
- Density
- 1,07 g/cm3
- refractive index
- 1.4576 (estimate)
- Flash point:
- 216 °C
- storage temp.
- Store below +30°C.
- solubility
- almost transparency in Methanol
- pka
- 11.89±0.23(Predicted)
- form
- Crystalline Powder
- color
- Light beige to pink-beige
- Water Solubility
- 3.8mg/L at 20℃
- BRN
- 2049542
- Stability:
- Stable. Incompatible with oxidizing agents.
- LogP
- 274 at 30℃
- CAS DataBase Reference
- 88-58-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-(88-58-4)
- EPA Substance Registry System
- 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)- (88-58-4)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-24/25
- WGK Germany
- 3
- RTECS
- MX5160000
- Autoignition Temperature
- 790 °F
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29072900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 8.21762
- Product name
- 2,5-Di-tert-butylhydroquinone
- Purity
- for synthesis
- Packaging
- 250g
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 8.21762
- Product name
- 2,5-Di-tert-butylhydroquinone
- Purity
- for synthesis
- Packaging
- 1kg
- Price
- $173
- Updated
- 2024/03/01
- Product number
- 8.21762
- Product name
- 2,5-Di-tert-butylhydroquinone
- Purity
- for synthesis
- Packaging
- 25kg
- Price
- $1520
- Updated
- 2024/03/01
- Product number
- 112976
- Product name
- 2,5-Di-tert-butylhydroquinone
- Purity
- 99%
- Packaging
- 25g
- Price
- $33.7
- Updated
- 2024/03/01
- Product number
- 112976
- Product name
- 2,5-Di-tert-butylhydroquinone
- Purity
- 99%
- Packaging
- 1kg
- Price
- $173
- Updated
- 2024/03/01
2,5-Di-tert-butylhydroquinone Chemical Properties,Usage,Production
Chemical Properties
cream or pale brown solid
Uses
2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.
Definition
ChEBI: A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5.
General Description
Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.
Biological Activity
A selective inhibitor of endoplasmic reticulum Ca 2+ -ATPase.
Biochem/physiol Actions
2,5-Di-tert-butylhydroquinone specifically inhibits the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle.
Purification Methods
Crystallise the hydroquinone from *C6H6 or AcOH. [Beilstein 6 III 4741.]
References
[1]. hasséssian h, vaca l, kunze dl. blockade of the inward rectifier potassium current by the ca(2+)-atpase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (bhq). br j pharmacol, 1994, 112(4): 1118-1122.
[2]. fusi f, gorelli b, valoti m, et al. effects of 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) on rat aorta smooth muscle. eur j pharmacol, 1998, 346(2-3): 237-243.
[3]. fusi f, saponara s, gagov h, et al. 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) inhibits vascular l-type ca(2+) channel via superoxide anion generation. br j pharmacol, 2001, 133(7): 988-996.
[4]. jan cr, ho cm, wu sn, et al. mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced ca2+ signals in madin darby canine kidney cells. eur j pharmacol, 1999, 365(1): 111-117.
2,5-Di-tert-butylhydroquinone Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2,5-Di-tert-butylhydroquinone manufacturers
- Product
- 2 5-di-tert-butylhydroquinone 88-58-4
- Price
- US $110.00-82.00/kg
- Min. Order
- 500kg
- Purity
- 99.9
- Supply Ability
- 200tons
- Release date
- 2024-03-13
- Product
- 2,5-Di-tert-butylhydroquinone 88-58-4
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Ton
- Release date
- 2023-03-24
- Product
- 2,5-Di-tert-butylhydroquinone 88-58-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-25