ChemicalBook > CAS DataBase List > 2,5-Di-tert-butylhydroquinone

2,5-Di-tert-butylhydroquinone

Product Name
2,5-Di-tert-butylhydroquinone
CAS No.
88-58-4
Chemical Name
2,5-Di-tert-butylhydroquinone
Synonyms
BHQ;dtbhq;DBHQ;Probes;ANTIOXIDANT DTBHQ;Dibutylhydroquinone;Black Hole Quencher;2,5-ditertiary butyl hydroquinone;2-carbamoyl-2-propylpentanoic acid;2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE
CBNumber
CB8258782
Molecular Formula
C14H22O2
Formula Weight
222.32
MOL File
88-58-4.mol
More
Less

2,5-Di-tert-butylhydroquinone Property

Melting point:
216-218 °C(lit.)
Boiling point:
321°C
Density 
1,07 g/cm3
refractive index 
1.4576 (estimate)
Flash point:
216 °C
storage temp. 
Store below +30°C.
solubility 
almost transparency in Methanol
pka
11.89±0.23(Predicted)
form 
Crystalline Powder
color 
Light beige to pink-beige
Water Solubility 
3.8mg/L at 20℃
BRN 
2049542
Stability:
Stable. Incompatible with oxidizing agents.
LogP
274 at 30℃
CAS DataBase Reference
88-58-4(CAS DataBase Reference)
NIST Chemistry Reference
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-(88-58-4)
EPA Substance Registry System
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)- (88-58-4)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-24/25
WGK Germany 
3
RTECS 
MX5160000
Autoignition Temperature
790 °F
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29072900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.21762
Product name
2,5-Di-tert-butylhydroquinone
Purity
for synthesis
Packaging
250g
Price
$48
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21762
Product name
2,5-Di-tert-butylhydroquinone
Purity
for synthesis
Packaging
1kg
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21762
Product name
2,5-Di-tert-butylhydroquinone
Purity
for synthesis
Packaging
25kg
Price
$1520
Updated
2024/03/01
Sigma-Aldrich
Product number
112976
Product name
2,5-Di-tert-butylhydroquinone
Purity
99%
Packaging
25g
Price
$33.7
Updated
2024/03/01
Sigma-Aldrich
Product number
112976
Product name
2,5-Di-tert-butylhydroquinone
Purity
99%
Packaging
1kg
Price
$173
Updated
2024/03/01
More
Less

2,5-Di-tert-butylhydroquinone Chemical Properties,Usage,Production

Description

2,5-Di-tert-butylhydroquinone, also known as 2,5-TBHQ or DTBHQ, belongs to the class of organic compounds known as phenylpropanes. These are organic compounds containing a phenylpropane moiety. It is a phenol derivative containing 2 phenol groups and 2 alkyl groups, each consisting of three methyl groups.

Chemical Properties

cream or pale brown solid

Uses

2,5-Di-tert-butylhydroquinone is the oxidation substrate used to measure the catalytic activity of the copper(II) enzyme-like catalysts.

Definition

ChEBI: A member of the class of hydroquinones that is benzene-1,4-diol substituted by tert-butyl groups at position 2 and 5.

General Description

Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.

Biological Activity

A selective inhibitor of endoplasmic reticulum Ca 2+ -ATPase.

Biochem/physiol Actions

2,5-Di-tert-butylhydroquinone specifically inhibits the sarcoplasmic reticulum (SR) Ca2+ uptake in the rat ventricle.

Purification Methods

Crystallise the hydroquinone from *C6H6 or AcOH. [Beilstein 6 III 4741.]

References

[1]. hasséssian h, vaca l, kunze dl. blockade of the inward rectifier potassium current by the ca(2+)-atpase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (bhq). br j pharmacol, 1994, 112(4): 1118-1122.
[2]. fusi f, gorelli b, valoti m, et al. effects of 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) on rat aorta smooth muscle. eur j pharmacol, 1998, 346(2-3): 237-243.
[3]. fusi f, saponara s, gagov h, et al. 2,5-di-t-butyl-1,4-benzohydroquinone (bhq) inhibits vascular l-type ca(2+) channel via superoxide anion generation. br j pharmacol, 2001, 133(7): 988-996.
[4]. jan cr, ho cm, wu sn, et al. mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced ca2+ signals in madin darby canine kidney cells. eur j pharmacol, 1999, 365(1): 111-117.

2,5-Di-tert-butylhydroquinone Preparation Products And Raw materials

Raw materials

Isobutylene Hydroquinone

Preparation Products

tert-Butylhydroquinone 6-Bromoindole-2-carboxylic acid (6-BROMO-1H-INDOL-2-YL)METHANOL 6-BROMO-1H-INDOLE-2-CARBALDEHYDE Ethyl 6-bromoindole-2-carboxylate
More
Less

2,5-Di-tert-butylhydroquinone Suppliers

Americas 1 Belgium 2 Canada 1 China 326 Europe 3 France 2 Germany 9 India 20 Indonesia 1 Japan 12 Slovakia 1 South Korea 1 Switzerland 4 Thailand 1 The Netherlands 1 United Kingdom 18 United States 48 Global 451
Hubei yongkuo Technology Co., Ltd
Tel
027-59223108 15972152991
Fax
027-59223108
Email
1248580099@qq.com
Country
China
ProdList
9988
Advantage
58
Hubei Wande Chemical Co., Ltd
Tel
027-59210159 15377098680
Fax
027-59210159
Email
1148280011@qq.com
Country
China
ProdList
9959
Advantage
58
Shandong Pepsi Food Technology Co. , Ltd.
Tel
0538-6386018 17753887766
Email
bsy@sdbaishiyi.com
Country
China
ProdList
3
Advantage
58
Powerful Chemical (Shanghai) Co., Ltd.
Tel
021-62211590 18917958225
Fax
021-54339019
Email
pwfchem@163.com
Country
China
ProdList
74
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
Country
China
ProdList
613
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
More
Less

View Lastest Price from 2,5-Di-tert-butylhydroquinone manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2 5-di-tert-butylhydroquinone 88-58-4
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-07
Hebei Weibang Biotechnology Co., Ltd
Product
2,5-Di-tert-butylhydroquinone 88-58-4
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-04-08
Shandong Juchuang Chemical Co., LTD
Product
2 5-di-tert-butylhydroquinone 88-58-4
Price
US $110.00-82.00/kg
Min. Order
500kg
Purity
99.9
Supply Ability
200tons
Release date
2024-03-13

88-58-4, 2,5-Di-tert-butylhydroquinoneRelated Search:

Diethylene glycol monobutyl ether Butyl acrylate 2,6-DIMETHYLHYDROQUINONE 2-Methylhydroquinone Hydroquinone Buprofezin tert-Butylhydroquinone 1,4-Dimethoxybenzene tert-Butanol 2-Butoxyethanol Cyhalofop-butyl Butyl acetate DI-TERT-BUTYL ETHER 2,5-Bis(1,1,3,3-tetramethylbutyl)hydroquinone 2,5-Di(tert-amyl)hydroquinone 2,6-di-tert-butylhydroquinone ALPHA-[[[2,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENOXY]CARBONYL]OXY]-2-NITRO-BENZENEACETIC ACID 2,5-DI-TERT-BUTYL-4-HYDROXYANISOLE

  • BHQ
  • DBHQ
  • Dibutylhydroquinone
  • DI-TERT-BUTYL HYDROQUINONE(2,5-)
  • DI-T-BUTYLHYDROQUINONE
  • 2,5-Di-tert-butylquinol
  • Di-Tertiary Butylhydroquinone
  • 2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE (DBHQ)
  • DTBHQ (DI-TERTIARY BUTYL
  • 4-Benzenediol,2,5-bis(1,1-dimethylethyl)-1
  • antagedbh
  • dibug
  • dtbhq
  • naugard451
  • nocracns7
  • NS-7
  • santovaro
  • 2,5 Di-tert-butyldroquinone
  • 2,5-Di-tert-butyl-1,4-dihydroxybenzene
  • 2,5-Bis(1,1-dimethylethyl)hydroquinone
  • DI-TERT-BUTYLHYDROQUINONE
  • 2,5-DI-TERT-BUTYL-HYDROQUINOL
  • 2,5-DI(TERT-BUTYL)-1,4-BENZOHYDROQUINONE
  • ANTIOXIDANT DTBHQ
  • 2,5-Di-tert-butylhydroquinone, 98+%
  • 2,5-Di-tert-butylhydroquinone,99%
  • BHQ / DBHQ
  • 2,5-DI-TERT-BUTYL HY
  • 2,5-Bis(tert-butyl)benzene-1,4-diol
  • 2,5-Bis(tert-butyl)hydroquinone
  • 2,5-Di-tert-butylhydroquinone (DBHQ)
  • 2,5-Di-tert-butylhydroquinone, 99% 1KG
  • 4-benzohydroquinone
  • 5-di-t-butyl-1
  • 2-carbamoyl-2-propylpentanoic acid
  • BUTYLHYDROQUINONE-TERT
  • 1,4-DIHYDROXY-2,5-DI-TERT-BUTYLBENZENE
  • T-BUTYLATED HYDROQUINONE
  • TBUBHQ
  • 2,5-BIS(2-METHYL-2-PROPYL)-1,4-BENZENEDIOL
  • 2,5-DI-TERT-BUTYL-1,4-HYDROQUINONE
  • 2,5-DI(TERT-BUTYL)-1,4-BENZENEDIOL
  • 2,5-ditertiary butyl hydroquinone
  • 2,5-DI-TERT-BUTYLHYDROQUINONE
  • 2,5-DI-TERT-BUTYL HYDROXYQUINONE
  • 2,5-DI-(T-BUTYL)-1,4-BENZOHYDROQUINONE
  • 2,5-DI-(T-BUTYL)-1,4-HYDROQUINONE
  • 2,5-DI-T-BUTYLHYDROQUINONE
  • 2.5-Di-tert-bu
  • BHQ Probes
  • Black Hole Quencher
  • Custom qPCR Probes
  • LNA probes
  • locked nucleic acid
  • Probes
  • qPCR assays
  • qPCR designs
  • Real-Time PCR Probes