ChemicalBook > CAS DataBase List > CEP-32496

CEP-32496

Product Name: CEP-32496
CAS No.: 1227678-26-3
Chemical Name: CEP-32496
Synonyms: CEP-32496;CEP-32496 HCl salt;CEP-32496 USP/EP/BP;RXDX105 hydrochloride;CEP32496 hydrochloride;RXDX 105 hydrochloride;RXDX-105 hydrochloride;CEP 32496 hydrochloride;Agerafenib hydrochloride;CEP-32496 (hydrochloride)
CBNumber: CB82596590
Molecular Formula: C24H23ClF3N5O5
Formula Weight: 553.9181296
MOL File: 1227678-26-3.mol

Less

CEP-32496 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: C256693
Product name: CEP-32496Hydrochloride
Packaging: 10mg
Price: $385
Updated: 2021/12/16

Usbiological

Product number: 474082
Product name: CEP 32496
Packaging: 100mg
Price: $1890
Updated: 2021/12/16

Matrix Scientific

Product number: 143691
Product name: 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride
Purity: 95%
Packaging: 1g
Price: $1998
Updated: 2021/12/16

AK Scientific

Product number: 3015AH
Product name: 1-(3-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)ureahydrochloride
Packaging: 1g
Price: $2747
Updated: 2021/12/16

Matrix Scientific

Product number: 143691
Product name: 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride
Purity: 95%
Packaging: 5g
Price: $5994
Updated: 2021/12/16

Less

CEP-32496 Chemical Properties,Usage,Production

Uses

CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.

in vivo

Oral administration of Agerafenib (CEP-32496) to Colo-205 tumor xenograft-bearing mice results in significant inhibition of pMEK in tumor cell lysates. For instance, a single 30 mg/kg (po) dose of Agerafenib (CEP-32496) leads to a 50 and 75% inhibition of normalized pMEK in tumor lysates at the 2 and 6 h postdose time point, respectively (p<0.03), while a 55 mg/kg (po) dose resulted in a 75% to 57% (p<0.03) inhibition of pMEK at 2 through 10 h post administration, with normalization to baseline by 24 h. Agerafenib (CEP-32496) exhibits an exceptional PK profile in mouse, dog, and cynomolgus monkey. Administration of Agerafenib (CEP-32496) to beagle dogs (single dose of 1 mg/kg iv and 10 mg/kg po) results in low clearance (CL=5.0 (mL/min)/kg) and excellent bioavailability (%F=100). Similarly, in cynomolgus monkey, the administration of Agerafenib (CEP-32496) (single dose of 1 mg/kg iv and 10 mg/kg po) leads to high oral exposure due to low clearance (CL=6.7 mL/min/kg) and excellent bioavailability (%F=100)^[1].

target

wild-type BRAF

IC 50

BRaf^V600E: 14 nM (Kd); Braf: 36 nM (Kd); CRAF: 39 nM (Kd); c-Kit: 2 nM (Kd); Ret: 2 nM (Kd); LCK: 2 nM (Kd); Abl-1: 3 nM (Kd); VEGFR-2: 8 nM (Kd); CSF-1R: 9 nM (Kd); EPHA2: 14 nM (Kd); EGFR: 22 nM (Kd); c-Met: 513 nM (Kd); JAK-2: 4700 nM (Kd); MEK-1: 7100 nM (Kd); MEK-2: 8300 nM (Kd)

CEP-32496 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CEP-32496 Suppliers

China 71 United States 9 Global 80

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4986
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Shanghai Rlavie Technology Co., Ltd.

Tel: 21-67759270 17717059219
Fax: QQ：1479352695
Email: sales@rlavie.com
Country: China
ProdList: 1620
Advantage: 55

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3276
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1984
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29496
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Sperui Technology (Guangzhou) Co., Ltd.

Tel: 18826050589
Country: CHINA
ProdList: 186
Advantage: 58

Guangzhou Weisheng Biotechnology Co., Ltd.

Tel: 17765667235
Country: CHINA
ProdList: 129
Advantage: 58

Shenzhen Science Biology Co., Ltd.

Tel: 18617181553
Country: CHINA
ProdList: 112
Advantage: 58

Chongqing Boer Biotechnology Co., Ltd.

Tel: 13251428727， 13368356747
Country: CHINA
ProdList: 157
Advantage: 58

Guangzhou Qingyan Biotechnology Co., Ltd.

Tel: 19802084049
Country: CHINA
ProdList: 171
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Chongqing Haoyu Biotechnology Co., Ltd.

Tel: 18983828904
Country: CHINA
ProdList: 114
Advantage: 58

Guangzhou Meijun Biotechnology Co., Ltd.

Tel: 18664742264
Country: CHINA
ProdList: 151
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Qincheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shqcsw01@163.com
Country: CHINA
ProdList: 6821
Advantage: 58

Beijing Luyuan Bird Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 15810802415@139.com
Country: CHINA
ProdList: 6750
Advantage: 58

Rhenbo (Shanghai) Biochemical Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6333
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6648
Advantage: 58

Nanjing Laifusai Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@lifescimall.com
Country: CHINA
ProdList: 6638
Advantage: 58

Beijing Dakco is Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: bj_info@dakewe.net
Country: CHINA
ProdList: 6580
Advantage: 58

Shanghai Shanran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: shanranbio@163.com
Country: CHINA
ProdList: 2846
Advantage: 58

Beijing Bai Ao Si Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: yangmei@bioneeds.net
Country: CHINA
ProdList: 6999
Advantage: 58

Shanghai Caiyou Industrial Co., Ltd.

Tel: --
Fax: --
Email: 15821073967@163.com
Country: CHINA
ProdList: 6748
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Wuhan Kehaojia Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 2248475041@qq.com
Country: CHINA
ProdList: 3048
Advantage: 58

Shenzhen Branch Science and Technology Co., Ltd.

Tel: --
Fax: --
Email: zikerbio@163.com
Country: CHINA
ProdList: 6374
Advantage: 58

Selleck Chemicals

Tel: --
Fax: --
Email: info@selleck.cn
Country: China
ProdList: 2542
Advantage: 65

1227678-26-3, CEP-32496Related Search:

Testolactone GDC-0077 AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7 UNC 0631 XL 228 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Ethyl 5-oxo-1-phenyl-2-pyrazoline-3-carboxylate 5-(1,1,1-Trifluoro-2-methylpropan-2-yl)isoxazol-3-amine Sorafenib Pazopanib Encorafenib (LGX818) Dabrafenib Regorafenib Plx-4032 (RG7024) PLX4032

CEP-32496

1-(3-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-Methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride

CEP 32496 hydrochloride

CEP-32496 (hydrochloride)

CEP32496 hydrochloride

CEP-32496 HCl salt

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxaz

N-[3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]urea hydrochloride

Agerafenib (CEP-32496) HCl

Agerafenib hydrochloride

CEP 32496 HYDROCHLORIDE;CEP32496 HYDROCHLORIDE;RXDX105 HYDROCHLORIDE;RXDX 105 HYDROCHLORIDE;RXDX-105 HYDROCHLORIDE;AGERAFENIB HYDROCHLORIDE

RXDX 105 hydrochloride

RXDX105 hydrochloride

RXDX-105 hydrochloride

CEP 32496 HYDROCHLORIDE; CEP32496 HYDROCHLORIDE

Agerafenib (CEP-32496) hydrochloride

CEP-32496 USP/EP/BP

1227678-26-3

C24H23ClF3N5O5

C24H22F3N5O5HCl