TYRPHOSTIN A51

Product Name: TYRPHOSTIN A51
CAS No.: 122520-90-5
Chemical Name: TYRPHOSTIN A51
Synonyms: AG 183;TYRPHOSTIN 51;TYRPHOSTIN A51;TYRPHOSTIN AG 183;TYRPHOSTIN A51 99+%;Tyrphostin 51(AG-183);TYRPHOSTIN A51 USP/EP/BP;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
CBNumber: CB8260628
Molecular Formula: C13H8N4O3
Formula Weight: 268.23
MOL File: 122520-90-5.mol

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TYRPHOSTIN A51 Property

Melting point:: 275 °C
Boiling point:: 788.2±60.0 °C(Predicted)
Density: 1.591±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: Orange solid.
pka: 8.46±0.15(Predicted)

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Safety

WGK Germany: 3
HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67135
Product name: Tyrphostin AG-183
Purity: 98%
Packaging: 5mg
Price: $56.8
Updated: 2021/12/16

Alfa Aesar

Product number: J67135
Product name: Tyrphostin AG-183
Purity: 98%
Packaging: 10mg
Price: $101
Updated: 2021/12/16

Cayman Chemical

Product number: 10010315
Product name: AG-183
Purity: ≥98%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 10010315
Product name: AG-183
Purity: ≥98%
Packaging: 10mg
Price: $76
Updated: 2024/03/01

Alfa Aesar

Product number: J67135
Product name: Tyrphostin AG-183
Purity: 98%
Packaging: 25mg
Price: $236
Updated: 2021/12/16

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TYRPHOSTIN A51 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC₅₀ value of 0.8 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..

Definition

ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol.

References

[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398.

TYRPHOSTIN A51 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN A51 Suppliers

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122520-90-5, TYRPHOSTIN A51Related Search:

TYRPHOSTIN A9 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib TYRPHOSTIN AG 1288 TYRPHOSTIN AG 126 TYRPHOSTIN A63 NS-398 AG 213 3-Aminocrotononitrile TYRPHOSTIN A51 2-AMINO-1-PROPENE-1,1,3-TRICARBONITRILE 2-PENTENENITRILE 3-Butenenitrile 2-PENTENENITRILE

AG 183

3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE

TYRPHOSTIN AG 183

TYRPHOSTIN A51

TYRPHOSTIN 51

2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE

2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-

TYRPHOSTIN A51 99+%

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-

TYRPHOSTIN A51 USP/EP/BP

Tyrphostin 51(AG-183)

122520-90-5

C13H8N4O3

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Epidermal Growth Factor Receptor (EGFR)

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors