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TYRPHOSTIN A51

Product Name
TYRPHOSTIN A51
CAS No.
122520-90-5
Chemical Name
TYRPHOSTIN A51
Synonyms
AG 183;TYRPHOSTIN 51;TYRPHOSTIN A51;TYRPHOSTIN AG 183;TYRPHOSTIN A51 99+%;Tyrphostin 51(AG-183);TYRPHOSTIN A51 USP/EP/BP;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
CBNumber
CB8260628
Molecular Formula
C13H8N4O3
Formula Weight
268.23
MOL File
122520-90-5.mol
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TYRPHOSTIN A51 Property

Melting point:
275 °C
Boiling point:
788.2±60.0 °C(Predicted)
Density 
1.591±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
Orange solid.
pka
8.46±0.15(Predicted)
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Safety

WGK Germany 
3
HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67135
Product name
Tyrphostin AG-183
Purity
98%
Packaging
5mg
Price
$56.8
Updated
2021/12/16
Alfa Aesar
Product number
J67135
Product name
Tyrphostin AG-183
Purity
98%
Packaging
10mg
Price
$101
Updated
2021/12/16
Cayman Chemical
Product number
10010315
Product name
AG-183
Purity
≥98%
Packaging
5mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
10010315
Product name
AG-183
Purity
≥98%
Packaging
10mg
Price
$76
Updated
2024/03/01
Alfa Aesar
Product number
J67135
Product name
Tyrphostin AG-183
Purity
98%
Packaging
25mg
Price
$236
Updated
2021/12/16
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TYRPHOSTIN A51 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..

Definition

ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol.

References

[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398.

TYRPHOSTIN A51 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN A51 Suppliers

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122520-90-5, TYRPHOSTIN A51Related Search:

TYRPHOSTIN A9 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib TYRPHOSTIN AG 1288 TYRPHOSTIN AG 126 TYRPHOSTIN A63 NS-398 AG 213 3-Aminocrotononitrile TYRPHOSTIN A51 2-AMINO-1-PROPENE-1,1,3-TRICARBONITRILE 2-PENTENENITRILE 3-Butenenitrile 2-PENTENENITRILE

  • AG 183
  • 3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
  • TYRPHOSTIN AG 183
  • TYRPHOSTIN A51
  • TYRPHOSTIN 51
  • 2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE
  • 2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE
  • 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-
  • TYRPHOSTIN A51 99+%
  • 1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-
  • TYRPHOSTIN A51 USP/EP/BP
  • Tyrphostin 51(AG-183)
  • 122520-90-5
  • C13H8N4O3
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Epidermal Growth Factor Receptor (EGFR)
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors