ChemicalBook > CAS DataBase List > BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

Product Name: BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-
CAS No.: 915759-45-4
Chemical Name: BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-
Synonyms: 316606;CS-2786;WAY-316606;WAY 316606;way-316606 /way 316606;WAY 316606, 10 mM in DMSO;WAY 316606 HCl(free base);WAY-316606;WAY 316606;WAY316606;2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1;5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
CBNumber: CB82627535
Molecular Formula: C18H19F3N2O4S2
Formula Weight: 448.48
MOL File: 915759-45-4.mol

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BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Property

Boiling point:: 601.1±65.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
solubility: DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka: 8.76±0.20(Predicted)
form: Powder
color: White to off-white
InChI: InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
InChIKey: ITBGJNVZJBVPLJ-UHFFFAOYSA-N
SMILES: C1(S(NC2CCNCC2)(=O)=O)=CC(S(C2=CC=CC=C2)(=O)=O)=CC=C1C(F)(F)F

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26324
Product name: WAY-316606
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 26324
Product name: WAY-316606
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 26324
Product name: WAY-316606
Packaging: 10mg
Price: $266
Updated: 2024/03/01

ChemScene

Product number: CS-0996
Product name: WAY316606
Purity: 99.61%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0996
Product name: WAY316606
Purity: 99.61%
Packaging: 10mg
Price: $220
Updated: 2021/12/16

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BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Chemical Properties,Usage,Production

Description

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC₅₀ = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC₅₀ = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.

Uses

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM[1].

Definition

ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound.

in vivo

WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC₅₀ of about 1 nM. WAY-316606 exhibits moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t_1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration^[2].

References

[1] Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116. DOI:10.1021/jm801144h
[2] Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. DOI:10.1016/j.bone.2009.02.013

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- manufacturers

Xi an Biohorlden Industry Trade Co Ltd

Product: WAY316606 915759-45-4
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 kg
Release date: 2025-04-22

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Way316606 ;Way-316606 915759-45-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-05-09

Hebei Yanxi Chemical Co., Ltd.

Product: WAY316606 915759-45-4
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-07

915759-45-4, BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-Related Search:

1-[4-(6-nitro-3-pyridinyl)-1-piperazinyl]ethanone 1-Methyl-4-piperidone WAY 100635 1,3-Benzenediol, 4-[1-(2-propenyl)-7-(trifluoromethyl)-1H-indazol-3-yl]- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 WAY-600 MAY-262611 WAY-151932 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

WAY 316606

WAY-316606

5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

WAY-316606;WAY 316606;WAY316606

5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide

CS-2786

way-316606 /way 316606

2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1

WAY 316606 HCl(free base)

WAY 316606, 10 mM in DMSO

316606

915759-45-4

915759-54-4

C18H19F3N2O4S2