PF 04447943

ChemicalBook > CAS DataBase List > PF 04447943

Product Name: PF 04447943
CAS No.: 1082744-20-4
Chemical Name: PF 04447943
Synonyms: EOS-62041;PF 4447943;PF-04447943;PF 04447943;PF 4447943;PF-4447943;PF04447943; PF 04447943;PF 04447943 - PF 4447943;PF-04447943 >=98% (HPLC);PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem;(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CBNumber: CB82645148
Molecular Formula: C20H25N7O2
Formula Weight: 395.46
MOL File: 1082744-20-4.mol

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PF 04447943 Property

Boiling point:: 599.8±60.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: -20C
solubility: Soluble in DMSO
form: Off-white solid
pka: 7.22±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.38337
Product name: PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem
Packaging: 10mg
Price: $246
Updated: 2024/03/01

Cayman Chemical

Product number: 24299
Product name: PF-04447943
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 24299
Product name: PF-04447943
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 24299
Product name: PF-04447943
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 24299
Product name: PF-04447943
Purity: ≥98%
Packaging: 25mg
Price: $384
Updated: 2024/03/01

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PF 04447943 Chemical Properties,Usage,Production

Biological Activity

pf-04447943 is a potent and selective inhibitor of pde9 [1].phosphodiesterase 9 (pde9) selectively degrades cgmp and limits the cgmp-mediated signal transduction which occurs following glutamate binding to nmda receptors. pde9 in cortex and hippocampus of rodents and humans play an important role in memory and learning [1].pf-04447943 have high affinity with ki of 2.8, 4.5 and 18 nm for human, rhesus and rat recombinant pde9 respectively and high selectivity for pde9 versus pdes1- 8 and 10 -11. in cultured hippocampal neurons, pf-04447943 (30-100 nm) significantly increased neurite outgrowth and synapse formation. also, pf-04447943 (100 nm) significantly facilitated hippocampal slice ltp evoked by a weak tetanic stimulus [1].in mice model, pf-04447943 (1 mg/kg) significantly reduced the time spent interacting with the female mouse during the second encounter 24 h later compared to the first encounter, which suggested that pf-04447943 enhanced recognition memory. while, pf-04447943 (3 or 10 mg/kg) didn’t change the interaction times for each encounter. these results suggested that pf-04447943 enhanced memory with an inverted u-shaped dose-response efficacy curve [1].

References

[1]hutson ph, finger en, magliaro bc, et al. the selective phosphodiesterase 9 (pde9) inhibitor pf-04447943(6-[(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2h-pyran-4-yl)-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. neuropharmacology, 2011, 61(4): 665-676.

PF 04447943 Preparation Products And Raw materials

Raw materials

Preparation Products

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1082744-20-4, PF 04447943Related Search:

PF 04447943

PF-04447943

1,5-Dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one

PF 4447943

6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(oxan-4-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-one

EOS-62041

6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

PF 4447943;PF-4447943

PF04447943; PF 04447943

PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem

PF 04447943 - PF 4447943

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-1-(tetrahydro-2H-pyran-4-yl)-

PF-04447943 >=98% (HPLC)

(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

1082744-20-4