S-Ruxolitinib (INCB018424)
- Product Name
- S-Ruxolitinib (INCB018424)
- CAS No.
- 941685-37-6
- Chemical Name
- S-Ruxolitinib (INCB018424)
- Synonyms
- CS-1401;INCB 18424;S-INCB18424;S-Ruxolitinib;Ruxolitinib Impurity A;S-Ruxolitinib (INCB018424);Ruxolitinib (S enantioMer);RUXOLITINIB S ENANTIOMER;INCB18424;S-Ruxolitinib INCB018424 INCB-018424;Ruxolitinib Impurity 1（(S)-Ruxolitinib）
- CBNumber
- CB82665159
- Molecular Formula
- C17H18N6
- Formula Weight
- 306.36
- MOL File
- 941685-37-6.mol
S-Ruxolitinib (INCB018424) Property
- Melting point:
- 138-143oC
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.63±0.50(Predicted)
- color
- White
N-Bromosuccinimide Price
- Product number
- C988940
- Product name
- (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile(ent-Ruxolitinib)
- Packaging
- 100mg
- Price
- $1465
- Updated
- 2021/12/16
- Product number
- orb154739
- Product name
- S-Ruxolitinib (INCB018424)
- Purity
- >98%
- Packaging
- 1g
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- CS-2768
- Product name
- Ruxolitinib(Senantiomer)
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-2768
- Product name
- Ruxolitinib(Senantiomer)
- Purity
- 99.92%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- CS-2768
- Product name
- Ruxolitinib(Senantiomer)
- Purity
- 99.92%
- Packaging
- 50mg
- Price
- $144
- Updated
- 2021/12/16
S-Ruxolitinib (INCB018424) Chemical Properties,Usage,Production
Uses
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile is a newly developed JAK2 inhibitor therapy aimed to improve MPN-associated splenomegaly and systemic symptoms. The opposite enantiomer of Ruxolitinib (R702000).
Biological Activity
s-ruxolitinib is the chirality of incb018424, is a potent and selective small-molecule janus kinase 1 (jak1) and jak2 inhibitor. it was initially developed to target the constitutive activation of the jak-stat pathway. janus kinases (jaks) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. ruxolitinib maintains its anti-jak activity by competitive inhibition of the atp-binding catalytic site of the kinase domain. ruxolitinib is well absorbed at >95%. exposure of jak2v617f-positive ba/f3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.ruben a. mesa, uma yasothan, peter kirkpatrick. ruxolitinib. nature reviews drug discovery. 2012; 11: 103-104john mascarenhas, ronald hoffman. ruxolitinib: the first fda approved therapy for the treatment of myelofibrosis. clinical cancer research. 2012; 18(11): 3008 - 3014
target
JAK1
S-Ruxolitinib (INCB018424) Preparation Products And Raw materials
Raw materials
Preparation Products
S-Ruxolitinib (INCB018424) Suppliers
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- Fax
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View Lastest Price from S-Ruxolitinib (INCB018424) manufacturers
- Product
- S-Ruxolitinib(INCB018424) 941685-37-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18