ChemicalBook > CAS DataBase List > ZLN005

ZLN005

Product Name: ZLN005
CAS No.: 49671-76-3
Chemical Name: ZLN005
Synonyms: ZLN005;CS-1004;ZLN005, >=98%;ZLN 005; ZLN-005;ZLN005, 10 mM in DMSO;2-(4-tert-Butylphenyl)benzimidazole;2-(4-tert-Butylphenyl)-1H-benzimidazole;2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE;ZLN005, PGC-1alpha transcriptional activator;2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole
CBNumber: CB82681122
Molecular Formula: C17H18N2
Formula Weight: 250.34
MOL File: 49671-76-3.mol

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ZLN005 Property

Melting point:: 257-258℃
Boiling point:: 415.3±38.0 °C(Predicted)
Density: 1.102±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
pka: 11.52±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0802
Product name: ZLN005
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $76.28
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0802
Product name: ZLN005
Purity: ≥95% (HPLC)
Packaging: 50mg
Price: $218.4
Updated: 2025/07/31

Cayman Chemical

Product number: 14121
Product name: ZLN005
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14121
Product name: ZLN005
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 14121
Product name: ZLN005
Purity: ≥98%
Packaging: 25mg
Price: $134
Updated: 2024/03/01

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ZLN005 Chemical Properties,Usage,Production

Description

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.

Uses

ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.

Synthesis

877-65-6

95-54-5

49671-76-3

The reaction was carried out in a magnetically stirred round-bottomed flask equipped with a condenser and placed in a temperature-controlled oil bath. O-phenylenediamine (2 mmol) was added to 4-tert-butylbenzyl alcohol (3 mmol) and the reaction mixture was stirred at 135 °C in an open (air) atmosphere. The reaction was monitored by TLC and after complete disappearance of the o-phenylenediamine or after the reaction had reached a predetermined time, the reaction mixture was cooled to room temperature. The crude product was purified by column chromatography on silica gel (100-200 mesh) to afford 2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazole. All products were structurally confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS) data.

in vivo

ZLN005 (15 mg/kg; p.o.; per day for 4 weeks) decreases random blood glucose and fasting blood glucose levels over 4 weeks compared with lean mice^[1].

Animal Model:	Eight-week-old db/db mice^[1]
Dosage:	15 mg/kg
Administration:	Oral administration; per day for 4 weeks
Result:	Random blood glucose and fasting blood glucose levels decreased significantly over 4 weeks compared with lean mice.

References

[1] Advanced Synthesis and Catalysis, 2017, vol. 359, # 19, p. 3332 - 3340
[2] Tetrahedron Letters, 2014, vol. 55, # 48, p. 6520 - 6525
[3] Catalysis Letters, 2018, vol. 148, # 1, p. 30 - 40
[4] New Journal of Chemistry, 2018, vol. 42, # 8, p. 6449 - 6456

ZLN005 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ZLN005 manufacturers

Career Henan Chemical Co

Product: ZLN-005 49671-76-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 96%
Supply Ability: 10kg
Release date: 2019-09-04

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2-(4-TERT-BUTYLPHENYL)-1H-BENZO[D]IMIDAZOLE

2-(4-tert-Butylphenyl)-1H-benzimidazole

2-(4-tert-Butylphenyl)benzimidazole

ZLN005, >=98%

2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole

2-(4-tert-Butylphenyl)benzimidazole ZLN005

ZLN005 2-(4-tert-Butylphenyl)benzimidazole

ZLN005

CS-1004

ZLN 005; ZLN-005

1H-Benzimidazole, 2-[4-(1,1-dimethylethyl)phenyl]-

ZLN005, PGC-1alpha transcriptional activator

ZLN005, 10 mM in DMSO

49671-76-3

Inhibitors