5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

ChemicalBook > CAS DataBase List > 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

Product Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
CAS No.: 1062368-49-3
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]
Synonyms: ALK2;(ML347);CS-1203;LDN 193719;VU 0469381;ML 347, >=98%;ML347(DN193719);ML-347(LDN-193719);5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a];ML 347;ML-347;LDN-193719;LDN193719;LDN 193719
CBNumber: CB82684613
Molecular Formula: C22H16N4O
Formula Weight: 352.39
MOL File: 1062368-49-3.mol

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5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] Property

Melting point:: 209-210℃
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥5.87 mg/mL in DMSO with gentle warming
form: solid
color: Light yellow to yellow

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Safety

RIDADR: 3077
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1273
Product name: ML347
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2022/05/15

Cayman Chemical

Product number: 17640
Product name: ML-347
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17640
Product name: ML-347
Purity: ≥95%
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Cayman Chemical

Product number: 17640
Product name: ML-347
Purity: ≥95%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 17640
Product name: ML-347
Purity: ≥95%
Packaging: 50mg
Price: $881
Updated: 2024/03/01

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5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] Chemical Properties,Usage,Production

Uses

LDN 193719 is a selective bone morphogenetic protein receptor (BMP) inhibitor for ALK2.

Biological Activity

ml347 is a potent and selective inhibitor of bone morphogenetic protein (bmp) receptor with ic50 value of 32nm against alk2 [1].ml347 is discovered as a selective inhibitor of bmp type-i receptor alk2 versus alk3 and is identified as a probe molecule. in the in vitro kinase assay, ml347 shows potent inhibitory activities against alk1 and alk2 with ic50 values of 46 and 32 nm, respectively. the ic50 value of it for alk3 is more than 10μm, demonstrating that ml347 is 300-fold more potent against alk2. besides that, ml347 exerts no inhibition effect on other related kinases such as alk6 and kdr. moreover, ml347 also shows effective inhibition with ic50 value of 152nm in the bmp4 cell based assay using c2c12bra cells [1].

storage

Store at +4°C

References

[1] engers d w, frist a y, lindsley c w, et al. synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (bmp) inhibitor derived from the pyrazolo [1.5-a] pyrimidine scaffold of dorsomorphin: the discovery of ml347 as an alk2 versus alk3 selective mlpcn probe. bioorganic & medicinal chemistry letters, 2013, 23(11): 3248-3252.

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] Preparation Products And Raw materials

Raw materials

Preparation Products

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1062368-49-3, 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]Related Search:

ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264 ML216 ALK5 inhibitor II Temsirolimus LDN-193189 LDN212854 K 02288

(ML347)

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]

ML-347(LDN-193719)

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

LDN 193719

Quinoline, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline ML-347(LDN-193719)

LDN 193719 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

ML347(DN193719)

ML 347, >=98%

ML 347;ML-347;LDN-193719;LDN193719;LDN 193719

VU 0469381

CS-1203

5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] USP/EP/BP

ALK2

Inhibitor,ML347,ML 347,ML-347,Transforming growth factor beta receptors,LDN193719,LDN-193719,inhibit,TGF-β Receptor,ALK1

1062368-49-3

Inhibitors