ChemicalBook > CAS DataBase List > Thiazolidine-4-carboxylic acid

Thiazolidine-4-carboxylic acid

Product Name
Thiazolidine-4-carboxylic acid
CAS No.
444-27-9
Chemical Name
Thiazolidine-4-carboxylic acid
Synonyms
TIMONACIC;THIOPROLINE;Timonacic Acid;t-4ca;Detoxepa;norgamem;nsc25855;Hepaldine;usafa-3701;AURORA 619
CBNumber
CB8271143
Molecular Formula
C4H7NO2S
Formula Weight
133.17
MOL File
444-27-9.mol
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Thiazolidine-4-carboxylic acid Property

Melting point:
196.5°C
Boiling point:
350.3±37.0 °C(Predicted)
Density 
1.226 (estimate)
refractive index 
1.5480 (estimate)
storage temp. 
Room Temperature
solubility 
DMSO (Slightly), Water (Slightly)
form 
solid
pka
2.09±0.20(Predicted)
Water Solubility 
29.3g/L(21 ºC)
CAS DataBase Reference
444-27-9(CAS DataBase Reference)
EPA Substance Registry System
4-Thiazolidinecarboxylic acid (444-27-9)
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Safety

RIDADR 
2811
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
I627
Product name
1,3-Thiazolidine-4-carboxylicacid
Packaging
100mg
Price
$81
Updated
2021/12/16
AK Scientific
Product number
J55101
Product name
1,3-Thiazolidine-4-carboxylicacid
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
174045
Product name
1,3-Thiazolidine-4-carboxylic acid
Packaging
1g
Price
$432
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015821
Product name
4-THIAZOLIDINECARBOXYLIC ACID
Purity
95.00%
Packaging
0.5G
Price
$605
Updated
2021/12/16
Matrix Scientific
Product number
174045
Product name
1,3-Thiazolidine-4-carboxylic acid
Packaging
5g
Price
$1206
Updated
2021/12/16
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Thiazolidine-4-carboxylic acid Chemical Properties,Usage,Production

Originator

Hepaldine,Riker,France,1964

Uses

hepatoprotectant

Uses

Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.

Definition

ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.

Manufacturing Process

Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.

Therapeutic Function

Hepatoprotectant, Choleretic

Thiazolidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Thiazolidine-4-carboxylic acid manufacturers

Career Henan Chemical Co
Product
Thiazolidine-4-carboxylic acid 444-27-9
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-15

444-27-9, Thiazolidine-4-carboxylic acidRelated Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2,2'-Dithiobis(benzothiazole) Moxifloxacin THIAZOLIDINE 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Moxifloxacin hydrochloride cis-4-Hydroxy-L-proline 2-Methyl-4-isothiazolin-3-one L-PROLINE-(4-3H(N)) 4-Thiazolecarboxylic acid D-Timolol maleate Benzothiazole Fosthiazate THIAZOLIDINE-2-CARBOXYLIC ACID thiazolo[4,5-b]pyridin-2-amine Thiazole-4,5-diyldimethanol Thiazolo[3,2-b][1,2,4]triazol-6-ylmethanamine tert-butyl thiazol-5-ylcarbamate

  • t-4ca
  • usafa-3701
  • TIMONACIC
  • THIOPROLINE
  • THIAZOLIDINE-4-CARBOXYLIC ACID
  • 1,3-THIAZOLIDINE-4-CARBOXYLIC ACID
  • AKOS BBS-00007512
  • AURORA 619
  • Thioproline Crystalline
  • L-Hepalidine
  • 4-THIOZOLIDINECARBOXYLICACID
  • 1-THIAZOLIDINE-4-CARBOXYLICACID
  • DL-Hepalidine
  • DL-Thiaproline
  • Tiazolidin
  • 4-Thiazolidinecarboxylic acid, L-
  • Detoxepa
  • Hepaldine
  • Heptaladine
  • 3-Thiazolidine-4-carboxylic acid
  • 4-thiazolidin-carboxylic acid
  • RS-4-Thiazolidinecarboxylic acid
  • 4-carboxythiazolidine
  • 4-thiazolidinecarboxylicacid
  • acidethiazolidine-4-carboxylique
  • gamma-thiaproline
  • hepalidine
  • heparegene
  • norgamem
  • nsc25855
  • hioproline
  • Timonacic Acid
  • Timonacic-d4Q: What is Timonacic-d4 Q: What is the CAS Number of Timonacic-d4
  • Thiamethoxam west acid
  • 444-27-9
  • Heterocyclic Compounds
  • DETOXEPA
  • API