ChemicalBook > CAS DataBase List > Thiazolidine-4-carboxylic acid

Thiazolidine-4-carboxylic acid

Product Name: Thiazolidine-4-carboxylic acid
CAS No.: 444-27-9
Chemical Name: Thiazolidine-4-carboxylic acid
Synonyms: TIMONACIC;THIOPROLINE;Timonacic Acid;t-4ca;Detoxepa;norgamem;nsc25855;Hepaldine;usafa-3701;AURORA 619
CBNumber: CB8271143
Molecular Formula: C4H7NO2S
Formula Weight: 133.17
MOL File: 444-27-9.mol

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Thiazolidine-4-carboxylic acid Property

Melting point:: 196.5°C
Boiling point:: 350.3±37.0 °C(Predicted)
Density: 1.226 (estimate)
refractive index: 1.5480 (estimate)
storage temp.: Room Temperature
solubility: DMSO (Slightly), Water (Slightly)
form: solid
pka: 2.09±0.20(Predicted)
color: White to off-white
Water Solubility: 29.3g/L(21 ºC)
InChI: InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)
InChIKey: DZLNHFMRPBPULJ-UHFFFAOYSA-N
SMILES: S1CC(C(O)=O)NC1
CAS DataBase Reference: 444-27-9(CAS DataBase Reference)
EPA Substance Registry System: 4-Thiazolidinecarboxylic acid (444-27-9)

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Safety

RIDADR: 2811
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: J55101
Product name: 1,3-Thiazolidine-4-carboxylicacid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: I627
Product name: 1,3-Thiazolidine-4-carboxylicacid
Packaging: 100mg
Price: $81
Updated: 2021/12/16

Matrix Scientific

Product number: 174045
Product name: 1,3-Thiazolidine-4-carboxylic acid
Packaging: 1g
Price: $432
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0015821
Product name: 4-THIAZOLIDINECARBOXYLIC ACID
Purity: 95.00%
Packaging: 0.5G
Price: $605
Updated: 2021/12/16

Matrix Scientific

Product number: 174045
Product name: 1,3-Thiazolidine-4-carboxylic acid
Packaging: 5g
Price: $1206
Updated: 2021/12/16

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Thiazolidine-4-carboxylic acid Chemical Properties,Usage,Production

Originator

Hepaldine,Riker,France,1964

Uses

hepatoprotectant

Uses

Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.

Definition

ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.

Manufacturing Process

Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.

Therapeutic Function

Hepatoprotectant, Choleretic

Thiazolidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Thiazolidine-4-carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Thiazolidine-4-carboxylic acid 444-27-9
Price: US $1.00-28.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-07-29

Career Henan Chemical Co

Product: Thiazolidine-4-carboxylic acid 444-27-9
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-15

444-27-9, Thiazolidine-4-carboxylic acidRelated Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2,2'-Dithiobis(benzothiazole) Moxifloxacin THIAZOLIDINE 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Moxifloxacin hydrochloride cis-4-Hydroxy-L-proline 2-Methyl-4-isothiazolin-3-one L-PROLINE-(4-3H(N)) 4-Thiazolecarboxylic acid D-Timolol maleate Benzothiazole Fosthiazate THIAZOLIDINE-2-CARBOXYLIC ACID thiazolo[4,5-b]pyridin-2-amine Thiazole-4,5-diyldimethanol Thiazolo[3,2-b][1,2,4]triazol-6-ylmethanamine tert-butyl thiazol-5-ylcarbamate

t-4ca

usafa-3701

TIMONACIC

THIOPROLINE

THIAZOLIDINE-4-CARBOXYLIC ACID

1,3-THIAZOLIDINE-4-CARBOXYLIC ACID

AKOS BBS-00007512

AURORA 619

Thioproline Crystalline

L-Hepalidine

4-THIOZOLIDINECARBOXYLICACID

1-THIAZOLIDINE-4-CARBOXYLICACID

DL-Hepalidine

DL-Thiaproline

Tiazolidin

4-Thiazolidinecarboxylic acid, L-

Detoxepa

Hepaldine

Heptaladine

3-Thiazolidine-4-carboxylic acid

4-thiazolidin-carboxylic acid

RS-4-Thiazolidinecarboxylic acid

4-carboxythiazolidine

4-thiazolidinecarboxylicacid

acidethiazolidine-4-carboxylique

gamma-thiaproline

hepalidine

heparegene

norgamem

nsc25855

hioproline

Timonacic Acid

Timonacic-d4Q: What is Timonacic-d4 Q: What is the CAS Number of Timonacic-d4

Thiamethoxam west acid

Timonacic, 10 mM in DMSO

444-27-9

Heterocyclic Compounds

DETOXEPA

API