Thiazolidine-4-carboxylic acid
- Product Name
- Thiazolidine-4-carboxylic acid
- CAS No.
- 444-27-9
- Chemical Name
- Thiazolidine-4-carboxylic acid
- Synonyms
- TIMONACIC;THIOPROLINE;Timonacic Acid;t-4ca;Detoxepa;norgamem;nsc25855;Hepaldine;usafa-3701;AURORA 619
- CBNumber
- CB8271143
- Molecular Formula
- C4H7NO2S
- Formula Weight
- 133.17
- MOL File
- 444-27-9.mol
Thiazolidine-4-carboxylic acid Property
- Melting point:
- 196.5°C
- Boiling point:
- 350.3±37.0 °C(Predicted)
- Density
- 1.226 (estimate)
- refractive index
- 1.5480 (estimate)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Water (Slightly)
- form
- solid
- pka
- 2.09±0.20(Predicted)
- color
- White to off-white
- Water Solubility
- 29.3g/L(21 ºC)
- CAS DataBase Reference
- 444-27-9(CAS DataBase Reference)
- EPA Substance Registry System
- 4-Thiazolidinecarboxylic acid (444-27-9)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I627
- Product name
- 1,3-Thiazolidine-4-carboxylicacid
- Packaging
- 100mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- J55101
- Product name
- 1,3-Thiazolidine-4-carboxylicacid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 174045
- Product name
- 1,3-Thiazolidine-4-carboxylic acid
- Packaging
- 1g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- API0015821
- Product name
- 4-THIAZOLIDINECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $605
- Updated
- 2021/12/16
- Product number
- 174045
- Product name
- 1,3-Thiazolidine-4-carboxylic acid
- Packaging
- 5g
- Price
- $1206
- Updated
- 2021/12/16
Thiazolidine-4-carboxylic acid Chemical Properties,Usage,Production
Originator
Hepaldine,Riker,France,1964
Uses
hepatoprotectant
Uses
Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells.
Definition
ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.
Manufacturing Process
Cysteine is first dissolved in distilled water which has been freed of oxygen by boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and the temperature of the mixture rises, while the thiazolidine carboxylic acid begins crystallizing. The stirring is continued for 2 hours after which ethyl alcohol of 95% (w/v) concentration is added to induce further crystallization. The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered with retention of a crude product, which is purified by recrystallization from boiling distilled water. The crystals are then dried at about 40°C. The free acid is then converted to the sodium salt with NaOH.
Therapeutic Function
Hepatoprotectant, Choleretic
Thiazolidine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thiazolidine-4-carboxylic acid manufacturers
- Product
- Thiazolidine-4-carboxylic acid 444-27-9
- Price
- US $1.00-28.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-07-29
- Product
- Thiazolidine-4-carboxylic acid 444-27-9
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-15