WS6
- Product Name
- WS6
- CAS No.
- 1421227-53-3
- Chemical Name
- WS6
- Synonyms
- WS6;CS-1811;WS-6;WS 6;WS6, >=98%;WS6 USP/EP/BP;WS6 >=98% (HPLC);WS6, 1421227-53-3;4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide;N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)methyl]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide;N-(6-(4-(2-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYLAMINO)-2-OXOETHYL)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE
- CBNumber
- CB82723011
- Molecular Formula
- C29H31F3N6O3
- Formula Weight
- 568.59
- MOL File
- 1421227-53-3.mol
WS6 Property
- Boiling point:
- 744.1±60.0 °C(Predicted)
- Density
- 1.374±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 11.82±0.20(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0757
- Product name
- WS6
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $56.8
- Updated
- 2024/03/01
- Product number
- SML0757
- Product name
- WS6
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $482
- Updated
- 2022/05/15
- Product number
- 17672
- Product name
- WS-6
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 17672
- Product name
- WS-6
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $91
- Updated
- 2024/03/01
- Product number
- 17672
- Product name
- WS-6
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
WS6 Chemical Properties,Usage,Production
Uses
WS6 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.
Biological Activity
ws6 is a small-molecule inducer of β cell proliferation [1].β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1].ws6 is a small-molecule inducer of β cell proliferation. in mouse β cell line r7t1, ws6 induced cell proliferation with ec50 value of 0.28 μm. ws6 was very active in primary human and rodent islets. in primary rat and human β cells, ws6 induced rat β cell proliferation with ec50 value of 0.4 μm and increased 4% of rat β cells and 3% of human β cells to proliferate. in intact islet cultures, ws6 significantly induced proliferation [1]. in cultured human islets, ws6 induced β cell proliferation and also α cell proliferation. however, ws6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that ws6 didn’t influence β cell differentiation and human islet cell viability [2].in type 1 diabetes (t1d) mice, ws6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1].
storage
Store at -20°C
References
[1]. shen w, tremblay ms, deshmukh va, et al. small-molecule inducer of β cell proliferation identified by high-throughput screening. j am chem soc, 2013, 135(5): 1669-1672.
[2]. boerner bp, george nm, mir su, et al. ws6 induces both alpha and beta cell proliferation without affecting differentiation or viability. endocr j, 2015, 62(4): 379-386.
WS6 Preparation Products And Raw materials
Raw materials
Preparation Products
WS6 Suppliers
View Lastest Price from WS6 manufacturers
- Product
- WS6 1421227-53-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02