ChemicalBook > CAS DataBase List > Dobutamine hydrochloride

Dobutamine hydrochloride

Product Name
Dobutamine hydrochloride
CAS No.
49745-95-1
Chemical Name
Dobutamine hydrochloride
Synonyms
DOBUTAMINE HCL;Dobutrex;46236;Dobux;Dopmin;Inotrex;NSC 299583;Dobutamine hydrochlo;Dobutamine hydrochloride;DL-Dobutamine hydrochloride
CBNumber
CB8274063
Molecular Formula
C18H24ClNO3
Formula Weight
337.84
MOL File
49745-95-1.mol
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Dobutamine hydrochloride Property

Melting point:
184-186 C
storage temp. 
2-8°C
solubility 
Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
pka
9.45(at 25℃)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water or ethanol with warming. Also soluble in methanol
λmax
281nm(MeOH)(lit.)
Merck 
14,3395
Stability:
Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
InChI
InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
InChIKey
BQKADKWNRWCIJL-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
CAS DataBase Reference
49745-95-1(CAS DataBase Reference)
EPA Substance Registry System
1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-63-36/37/38-R63-R62-R11-R21-R20
Safety Statements 
22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22
WGK Germany 
3
HS Code 
29222990
Toxicity
LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D0676
Product name
Dobutamine hydrochloride
Purity
≥98%
Packaging
10mg
Price
$84.7
Updated
2024/03/01
Sigma-Aldrich
Product number
BP674
Product name
Dobutamine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
1224507
Product name
Dobutamine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
400mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
D4335
Product name
Dobutamine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D4335
Product name
Dobutamine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$110
Updated
2024/03/01
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Dobutamine hydrochloride Chemical Properties,Usage,Production

Description

Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.

Chemical Properties

Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.

Uses

Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.

Uses

Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.

Definition

ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.

brand name

Dobutrex (Lilly）.

Biological Activity

β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Pharmacokinetics

Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.

Veterinary Drugs and Treatments

Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.

storage

Desiccate at RT

Dobutamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Dobutamine hydrochloride Suppliers

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View Lastest Price from Dobutamine hydrochloride manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Dobutamine hydrochloride 49745-95-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
500 kgs
Release date
2024-05-15
airuikechemical co., ltd.
Product
Dobutamine hydrochloride 49745-95-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-03-13
Baoji Guokang Healthchem co.,ltd
Product
DOBUTAMINE HYDROCHLORIDE 49745-95-1
Price
US $5238.10/KG
Min. Order
20g
Purity
99%
Supply Ability
3000g
Release date
2021-06-08

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