Seratrodast
- Product Name
- Seratrodast
- CAS No.
- 112665-43-7
- Chemical Name
- Seratrodast
- Synonyms
- CS-324;Bronic;aa-2414;Seretra;Bronica;ABT-001;Serabenast;CCRIS 8939;Seratrodast;50MG/200MG/1G
- CBNumber
- CB8284400
- Molecular Formula
- C22H26O4
- Formula Weight
- 354.44
- MOL File
- 112665-43-7.mol
Seratrodast Property
- Melting point:
- 118-120°C
- Boiling point:
- 522.3±49.0 °C(Predicted)
- Density
- 1.140±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.76±0.10(Predicted)
- form
- Yellow-orange solid.
- color
- Pale Orange to Yellow
- Merck
- 14,8459
- CAS DataBase Reference
- 112665-43-7(CAS DataBase Reference)
Safety
- RTECS
- DA1600050
- HS Code
- 2918.30.3000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S0943
- Product name
- Seratrodast
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $199
- Updated
- 2024/03/01
- Product number
- S0943
- Product name
- Seratrodast
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 9002014
- Product name
- Seratrodast
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 9002014
- Product name
- Seratrodast
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 9002014
- Product name
- Seratrodast
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $235
- Updated
- 2024/03/01
Seratrodast Chemical Properties,Usage,Production
Description
Seratrodast, a novel benzoquinone derivative, is the first thromboxane A2 (TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA2 mimic and by a variety of spasmogenic prostanoids including PGF2α, PGD2 and 9α,11β-PGF2. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.
Chemical Properties
Pale Orange Solid
Originator
Takeda (Japan)
Uses
Thromboxane A2-receptor antagonist. Antiasthmatic.
Uses
antibacterial
Definition
ChEBI: Seratrodast is an organic molecular entity.
brand name
Bronica
Biological Activity
Thromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.
in vitro
seratrodast was found to inhibit the aggregation of guinea pig platelets induced by a prostaglandin endoperoxide analogue, u-44069 and the specific binding of another analogue, [3h]u-46619 to washed guinea pig platelets. seratrodast could competitively inhibit the contraction of rabbit aorta and pig coronary arteries induced by u-44069. seratrodast also inhibited the contraction of rabbit aorta induced by pgf2 alpha and the contraction of pig coronary arteries. however, seratrodast had no effect on the antiaggregatory effect of guinea pig platelets [1].
in vivo
in experiments with guinea pigs, oral seratrodast at 0.1-1 mg/kg could dose-dependently inhibit the platelet aggregation induced by u-44069; the inhibition at 1 mg/kg was 100% at 1 hr and was 89% even at 24 hr after seratrodast administration [1].
IC 50
7.4 nm for guinea pig platelets
References
[1] imura, y. ,terashita, z.,shibouta, y., et al. antagonistic action of aa-2414 on thromboxane a2/prostaglandin endoperoxide receptor in platelets and blood vessels. japanese journal of pharmacology 52(1), 35-53 (1990).
Seratrodast Preparation Products And Raw materials
Raw materials
Preparation Products
Seratrodast Suppliers
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- 0537-2983357
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View Lastest Price from Seratrodast manufacturers
- Product
- Seratrodast 112665-43-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-14
- Product
- Seratrodast 112665-43-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-09-27
- Product
- Seratrodast 112665-43-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11