ChemicalBook > CAS DataBase List > Seratrodast

Seratrodast

Product Name
Seratrodast
CAS No.
112665-43-7
Chemical Name
Seratrodast
Synonyms
CS-324;Bronic;aa-2414;Seretra;Bronica;ABT-001;Serabenast;CCRIS 8939;Seratrodast;50MG/200MG/1G
CBNumber
CB8284400
Molecular Formula
C22H26O4
Formula Weight
354.44
MOL File
112665-43-7.mol
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Seratrodast Property

Melting point:
118-120°C
Boiling point:
522.3±49.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
4.76±0.10(Predicted)
form 
Yellow-orange solid.
color 
Pale Orange to Yellow
Merck 
14,8459
CAS DataBase Reference
112665-43-7(CAS DataBase Reference)
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Safety

RTECS 
DA1600050
HS Code 
2918.30.3000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
S0943
Product name
Seratrodast
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$199
Updated
2024/03/01
TCI Chemical
Product number
S0943
Product name
Seratrodast
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9002014
Product name
Seratrodast
Purity
≥98%
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
9002014
Product name
Seratrodast
Purity
≥98%
Packaging
25mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
9002014
Product name
Seratrodast
Purity
≥98%
Packaging
50mg
Price
$235
Updated
2024/03/01
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Seratrodast Chemical Properties,Usage,Production

Description

Seratrodast, a novel benzoquinone derivative, is the first thromboxane A2 (TxA2) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA2, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA2 mimic and by a variety of spasmogenic prostanoids including PGF2α, PGD2 and 9α,11β-PGF2. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.

Chemical Properties

Pale Orange Solid

Originator

Takeda (Japan)

Uses

Thromboxane A2-receptor antagonist. Antiasthmatic.

Uses

antibacterial

Definition

ChEBI: Seratrodast is an organic molecular entity.

brand name

Bronica

Biological Activity

Thromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.

in vitro

seratrodast was found to inhibit the aggregation of guinea pig platelets induced by a prostaglandin endoperoxide analogue, u-44069 and the specific binding of another analogue, [3h]u-46619 to washed guinea pig platelets. seratrodast could competitively inhibit the contraction of rabbit aorta and pig coronary arteries induced by u-44069. seratrodast also inhibited the contraction of rabbit aorta induced by pgf2 alpha and the contraction of pig coronary arteries. however, seratrodast had no effect on the antiaggregatory effect of guinea pig platelets [1].

in vivo

in experiments with guinea pigs, oral seratrodast at 0.1-1 mg/kg could dose-dependently inhibit the platelet aggregation induced by u-44069; the inhibition at 1 mg/kg was 100% at 1 hr and was 89% even at 24 hr after seratrodast administration [1].

IC 50

7.4 nm for guinea pig platelets

References

[1] imura, y. ,terashita, z.,shibouta, y., et al. antagonistic action of aa-2414 on thromboxane a2/prostaglandin endoperoxide receptor in platelets and blood vessels. japanese journal of pharmacology 52(1), 35-53 (1990).

Seratrodast Preparation Products And Raw materials

Raw materials

(1S)-(+)-Camphor-10-sulphonic acid Trimethylhydroquinone Phenol Ferric chloride Heptanoic acid

Preparation Products

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View Lastest Price from Seratrodast manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Seratrodast 112665-43-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
Seratrodast 112665-43-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Seratrodast 112665-43-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

112665-43-7, SeratrodastRelated Search:

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  • 50MG/200MG/1G
  • benzeneheptanoic acid, -(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-
  • (+-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoicacid
  • aa-2414
  • beta-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-bezeneheptanoicaci
  • Seratrodast(AA-2414,ABT-001)
  • AA-2414;SERETRA;AA2414;AA 2414
  • Seretra
  • Seratrodast AA 2414
  • CS-324
  • 5-(2,4,5-trimethyl-3,6,-dioxo-1,4-cyclohexadien-1-yl)benzeneheptanoic acid
  • 7-(3,5,6-trimethy1-1,4-benzoquinon-2-y1)-7-phenylheptanoic acid
  • 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-1-cyclohexa-1,4-dienyl)heptanoic acid
  • Bronica
  • Abbott 73001
  • Bronic
  • (±)-ζ-2，4，5-Trimethyl-3，6-dioxo-1，4-cyclohexadien-1-y1)benzeneheptanoic acid
  • 7-(3,6-diketo-2,4,5-trimethyl-cyclohexa-1,4-dien-1-yl)-7-phenyl-enanthic acid
  • 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dien-1-yl)heptanoic acid
  • 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid
  • Serabenast
  • Seratrodast
  • Seratrodast &gt
  • ABT-001
  • Seratrodast USP/EP/BP
  • CCRIS 8939
  • Seratrodast, 10 mM in DMSO
  • 112665-43-7
  • C22H26O4
  • ZAGAM
  • API
  • Heterocyclic Compounds
  • Intermediates & Fine Chemicals
  • Pharmaceuticals