ChemicalBook > CAS DataBase List > Ethyl 1-methylnipecotate

Ethyl 1-methylnipecotate

Product Name
Ethyl 1-methylnipecotate
CAS No.
5166-67-6
Chemical Name
Ethyl 1-methylnipecotate
Synonyms
NSC 64739;LABOTEST-BB LT00159658;ETHYL 1-METHYLNIPECOTATE;Ethyl 1-methylnipecotate, 98+%;1-Methyl-nipecotic acid ethyl ester;Ethyl-1-methylpiperidin-3-carboxylat;Ethyl N-Methylpiperidine-3-carboxylate;ETHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE;thyl N-methyl piperidine-3-carboxylate;ETHYL 1-METHYL-3-PIPERIDINE-CARBOXYLATE
CBNumber
CB8289450
Molecular Formula
C9H17NO2
Formula Weight
171.24
MOL File
5166-67-6.mol
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Ethyl 1-methylnipecotate Property

Boiling point:
88-89 °C/11 mmHg (lit.)
Density 
0.954 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.451(lit.)
Flash point:
155 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
pka
8.56±0.10(Predicted)
color 
Colorless to Almost colorless
BRN 
123259
CAS DataBase Reference
5166-67-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl 1-methylnipecotate(5166-67-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37/39
WGK Germany 
3
F 
9-23
Hazard Note 
Irritant
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
194352
Product name
Ethyl 1-methyl-3-piperidinecarboxylate
Purity
96%
Packaging
5g
Price
$92.4
Updated
2023/06/20
TCI Chemical
Product number
E0863
Product name
Ethyl 1-Methyl-3-piperidinecarboxylate
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
E0863
Product name
Ethyl 1-Methyl-3-piperidinecarboxylate
Purity
>95.0%(GC)(T)
Packaging
25g
Price
$140
Updated
2025/07/31
TRC
Product number
E926783
Product name
Ethyl1-Methylpiperidine-3-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
43446
Product name
Ethyl1-methyl-3-piperidinecarboxylate,≥95%(GC)
Purity
≥95%(GC)
Packaging
5G
Price
$46.22
Updated
2021/12/16
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Ethyl 1-methylnipecotate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale yellow liquid

Uses

Reactant for:
N-demethylation of tertiary amines
Reverse cope elimination reactions
Regioselective oxidation
Synthesis of chelating agents
Sequential Michael-Michael-Dieckmann cyclizations

General Description

Enantiomeric discrimination has been investigated in 1H and 13C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.

Synthesis

122-51-0

71962-74-8

5166-67-6

The general procedure for the synthesis of ethyl 1-methyl-3-piperidinecarboxylate from triethyl orthoformate and ethyl crotonate is as follows: in an autoclave, a 1 molar concentration of catalyst based on the molar amount of amine is added, and after displacing the air in the autoclave with argon, 0.1 moles of amine and 0.11-0.3 moles of o-carboxylic acid ester dissolved in a 10 ml solution in methanol (or ethanol) are added, as well as 0.5 ml of 0.2 M anhydrous p-toluene benzenesulfonic acid solution in methanol (or ethanol). The reaction mixture was heated to 120°C and charged with hydrogen gas to a pressure of 40 bar. The reaction mixture was stirred continuously at a constant pressure until the absorption of hydrogen ceased (reaction time of about 0.2-6 hours). After completion of the reaction, the catalyst was removed by filtration and the filtrate was distilled to purify the target product.

References

[1] Patent: WO2017/133913, 2017, A1. Location in patent: Page/Page column 9; 14

Ethyl 1-methylnipecotate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 1-methylnipecotate Suppliers

Americas 1 Belgium 1 China 153 Europe 1 Germany 5 India 4 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 4 United States 20 Global 192
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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HBCChem, Inc.
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View Lastest Price from Ethyl 1-methylnipecotate manufacturers

Wuhan Xinhao Biotechnology Co., Ltd
Product
Ethyl 1-methylnipecotate 5166-67-6
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-20
Hebei Fengqiang Trading Co., LTD
Product
thyl N-methyl piperidine-3-carboxylate 5166-67-6
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-09-11
Shanghai CRM New Material Technology Co., LTD
Product
Ethyl-1-methylpiperidin-3-carboxylat 5166-67-6
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
2546245
Release date
2022-09-23

5166-67-6, Ethyl 1-methylnipecotateRelated Search:

Ethylparaben Triethyl orthoformate 2,2,6,6-Tetramethyl-4-piperidinol Urethane Ethyl formate Nipecotic acid Ethyl cyanoacetate Ethyl acetate Bensulfuron methyl Methyl acrylate Ethyl acrylate Trinexapac-ethyl ISOXADIFEN-ETHYL Methyl acetate Methylparaben Triacetonediamine Thiophanate-methyl Kresoxim-methyl

  • Ethyl 1-methylnipecotate, 98+%
  • 1-Methyl-3-piperidinecarboxylic acid ethyl ester
  • ETHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE
  • ETHYL 1-METHYLNIPECOTATE
  • ETHYL 1-METHYL-3-PIPERIDINE-CARBOXYLATE
  • Ethyl 1-methylpiperidine-3-carboxylate 97%
  • Ethyl N-Methyl piperidine-3-carboxylate or Ethyl 1-Methylnipecotate
  • Ethyl N-Methylpiperidine-3-carboxylate
  • 1-Methylnipecotic Acid Ethyl Ester Ethyl 1-Methylnipecotate 1-Methyl-3-piperidinecarboxylic Acid Ethyl Ester
  • 1-Methyl-nipecotic acid ethyl ester
  • NSC 64739
  • LABOTEST-BB LT00159658
  • 3-Piperidinecarboxylic acid, 1-methyl-, ethyl ester
  • 1-METHYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER
  • Ethyl 1-methyl-3-piperidinecarboxylate cas 5166-67-6
  • Ethyl1-Methyl-3-piperidinecarboxylate&gt
  • N-methylpiperidine-3-carboxylate, ethyl ester
  • Ethyl-1-methylpiperidin-3-carboxylat
  • thyl N-methyl piperidine-3-carboxylate
  • 5166-67-6
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • Heterocyclic Compounds