ChemicalBook > CAS DataBase List > 3-Cyano-5-fluorobenzoic acid

3-Cyano-5-fluorobenzoic acid

Product Name: 3-Cyano-5-fluorobenzoic acid
CAS No.: 327056-74-6
Chemical Name: 3-Cyano-5-fluorobenzoic acid
Synonyms: 3-CYANO-5-FLUOROBENZOIC ACID;3-Carboxy-5-fluorobenzonitrile;Benzoic acid, 3-cyano-5-fluoro-;3-Cyano-5-fluorobenzoic acid 98%;Benzoic acid, 3-cyano-5-fluoro- (9CI);3-CYANO-5-FLUOROBENZOIC ACID, 98% MIN.
CBNumber: CB8290379
Molecular Formula: C8H4FNO2
Formula Weight: 165.12
MOL File: 327056-74-6.mol

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3-Cyano-5-fluorobenzoic acid Property

Melting point:: 172-173°C
Boiling point:: 317.0±27.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.30±0.10(Predicted)
Appearance: Off-white to light yellow Solid
Sensitive: Air Sensitive

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 22
RIDADR: 2811
HazardClass: IRRITANT, TOXIC
PackingGroup: Ⅲ
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C956080
Product name: 3-Cyano-5-fluorobenzoicAcid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

TRC

Product number: C956080
Product name: 3-Cyano-5-fluorobenzoicAcid
Packaging: 5g
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021770
Product name: 3-CYANO-5-FLUOROBENZOIC ACID
Purity: 95.00%
Packaging: 5G
Price: $797.32
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021770
Product name: 3-CYANO-5-FLUOROBENZOIC ACID
Purity: 95.00%
Packaging: 25G
Price: $1221.41
Updated: 2021/12/16

Matrix Scientific

Product number: 011291
Product name: 3-Cyano-5-fluorobenzoic acid
Purity: 98%
Packaging: 25g
Price: $171
Updated: 2021/12/16

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3-Cyano-5-fluorobenzoic acid Chemical Properties,Usage,Production

Uses

3-Cyano-5-fluorobenzoic Acid is an intermediate used to prepare arylbenzamides as negative allosteric modulators of mGlu5R.

Synthesis

327056-72-4

327056-74-6

The general procedure for the synthesis of 3-cyano-5-fluorobenzoic acid from methyl 3-chloro-5-cyanobenzoate was as follows: the crude methyl 3-chloro-5-cyanobenzoate was dissolved in 350 mL of methanol at room temperature, 45 mL of 4N sodium hydroxide solution (180 mmol) was added, and the reaction was carried out for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate and the organic phase was washed with 5% aqueous hydrochloric acid and saturated saline in turn. Finally, it was purified by silica gel column chromatography to afford 7.0 g (54% yield) of the target product 3-cyano-5-fluorobenzoic acid.

References

[1] Patent: US2003/55085, 2003, A1

3-Cyano-5-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Cyano-5-fluorobenzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Cyano-5-fluorobenzoic acid 327056-74-6
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-07

Career Henan Chemical Co

Product: 3-Cyano-5-fluorobenzoic acid 327056-74-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-10

327056-74-6, 3-Cyano-5-fluorobenzoic acidRelated Search:

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3-CYANO-5-FLUOROBENZOIC ACID

3-CYANO-5-FLUOROBENZOIC ACID, 98% MIN.

3-Carboxy-5-fluorobenzonitrile

3-Cyano-5-fluorobenzoic acid 98%

Benzoic acid, 3-cyano-5-fluoro- (9CI)

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327056-74-6

Fluorine series

HALIDE

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts