3-Cyano-5-fluorobenzoic acid
- Product Name
- 3-Cyano-5-fluorobenzoic acid
- CAS No.
- 327056-74-6
- Chemical Name
- 3-Cyano-5-fluorobenzoic acid
- Synonyms
- 3-CYANO-5-FLUOROBENZOIC ACID;3-Carboxy-5-fluorobenzonitrile;Benzoic acid, 3-cyano-5-fluoro-;3-Cyano-5-fluorobenzoic acid 98%;Benzoic acid, 3-cyano-5-fluoro- (9CI);3-CYANO-5-FLUOROBENZOIC ACID, 98% MIN.
- CBNumber
- CB8290379
- Molecular Formula
- C8H4FNO2
- Formula Weight
- 165.12
- MOL File
- 327056-74-6.mol
3-Cyano-5-fluorobenzoic acid Property
- Melting point:
- 172-173°C
- Boiling point:
- 317.0±27.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.30±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- Sensitive
- Air Sensitive
N-Bromosuccinimide Price
- Product number
- C956080
- Product name
- 3-Cyano-5-fluorobenzoicAcid
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- C956080
- Product name
- 3-Cyano-5-fluorobenzoicAcid
- Packaging
- 5g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- HCH0021770
- Product name
- 3-CYANO-5-FLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $797.32
- Updated
- 2021/12/16
- Product number
- HCH0021770
- Product name
- 3-CYANO-5-FLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1221.41
- Updated
- 2021/12/16
- Product number
- 011291
- Product name
- 3-Cyano-5-fluorobenzoic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $171
- Updated
- 2021/12/16
3-Cyano-5-fluorobenzoic acid Chemical Properties,Usage,Production
Uses
3-Cyano-5-fluorobenzoic Acid is an intermediate used to prepare arylbenzamides as negative allosteric modulators of mGlu5R.
Synthesis
327056-72-4
327056-74-6
The general procedure for the synthesis of 3-cyano-5-fluorobenzoic acid from methyl 3-chloro-5-cyanobenzoate was as follows: the crude methyl 3-chloro-5-cyanobenzoate was dissolved in 350 mL of methanol at room temperature, 45 mL of 4N sodium hydroxide solution (180 mmol) was added, and the reaction was carried out for 4 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate and the organic phase was washed with 5% aqueous hydrochloric acid and saturated saline in turn. Finally, it was purified by silica gel column chromatography to afford 7.0 g (54% yield) of the target product 3-cyano-5-fluorobenzoic acid.
References
[1] Patent: US2003/55085, 2003, A1
3-Cyano-5-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Cyano-5-fluorobenzoic acid Suppliers
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
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- Country
- India
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- Advantage
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- Country
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View Lastest Price from 3-Cyano-5-fluorobenzoic acid manufacturers
- Product
- 3-Cyano-5-fluorobenzoic acid 327056-74-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 3-Cyano-5-fluorobenzoic acid 327056-74-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-10