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2-Chloro-5-nitronicotinic acid

Application
Product Name
2-Chloro-5-nitronicotinic acid
CAS No.
42959-38-6
Chemical Name
2-Chloro-5-nitronicotinic acid
Synonyms
2-Chloro-5-nitronicotinicaci;2-Chloro-5-nitronicoinic acid;2-CHLORO-5-NITRONICOTINIC ACID;2-Chloro-5-nitropyridin-3-carboxylic acid;2-CHLORO-5-NITROPYRIDINE-3-CARBOXYLIC ACID;2-Chloro-5-nitro-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-chloro-5-nitro-;2-Chloro-5-nitropyridine-3-carboxylic acid, 3-Carboxy-2-chloro-5-nitropyridine
CBNumber
CB8291477
Molecular Formula
C6H3ClN2O4
Formula Weight
202.55
MOL File
42959-38-6.mol
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2-Chloro-5-nitronicotinic acid Property

Melting point:
140-143℃
Boiling point:
384.8±42.0 °C(Predicted)
Density 
1.702±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
form 
Solid
pka
1.57±0.10(Predicted)
color 
White to yellow
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C6H3ClN2O4/c7-5-4(6(10)11)1-3(2-8-5)9(12)13/h1-2H,(H,10,11)
InChIKey
WOFZRBCITDVRON-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C=C1C(O)=O
CAS DataBase Reference
42959-38-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C381113
Product name
2-Chloro-5-nitronicotinicacid
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
055440
Product name
2-Chloro-5-nitronicotinic acid
Purity
95+%
Packaging
25g
Price
$84
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-5-X1
Product name
2-Chloro-5-nitronicotinic acid
Purity
95%
Packaging
250mg
Price
$24
Updated
2021/12/16
Matrix Scientific
Product number
055440
Product name
2-Chloro-5-nitronicotinic acid
Purity
95+%
Packaging
5g
Price
$24
Updated
2021/12/16
Matrix Scientific
Product number
055440
Product name
2-Chloro-5-nitronicotinic acid
Purity
95+%
Packaging
100g
Price
$236
Updated
2021/12/16
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2-Chloro-5-nitronicotinic acid Chemical Properties,Usage,Production

Application

2-Chloro-5-nitronicotinic acid is a chemical intermediate used in the synthesis of pesticides and pharmaceuticals. For example, Rhône-Poulenc Agribusiness in France uses it to synthesize novel herbicides.

Synthesis

2-Hydroxy-5-nitro-nicotinic acid (2.7 mmol) in a mixture of NJV- dimethylformamide (2.7 mmol) and thionyl chloride (5 ml) was heated at 80 0C for 1 h. The mixture was allowed to cool and concentrated in a vacuum. To the resulting residue, ice water (20 ml) was added, and with vigorous stirring, a precipitate formed. The precipitate was filtered off and dried in a vacuum oven to give a white solid 2-Chloro-5-nitronicotinic acid (68 percent).

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 10, p. 1887 - 1897
[2] Beilstein Journal of Organic Chemistry, 2009, vol. 5,
[3] Patent: EP904262, 2004, B1. Location in patent: Page 244
[4] Patent: WO2008/46135, 2008, A1. Location in patent: Page/Page column 42-43
[5] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1151 - 1154

2-Chloro-5-nitronicotinic acid Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2-Hydroxynicotinic acid Hexane Sodium sulfate Phosphorus oxitrichloride Tetrahydrofuran Diethyl ether Nitric acid

Preparation Products

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2-Chloro-5-nitronicotinic acid Suppliers

Canada 1 China 182 Europe 2 India 5 United Kingdom 2 United States 24 Global 216
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Atlantic Research Chemicals Ltd.
Tel
--
Fax
--
Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
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View Lastest Price from 2-Chloro-5-nitronicotinic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-5-nitronicotinic acid 42959-38-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-18
Career Henan Chemical Co
Product
2-Chloro-5-nitronicotinic acid 42959-38-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11
Career Henan Chemical Co
Product
2-Chloro-5-nitronicotinic acid 42959-38-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-25

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