3,5-Dinitrobenzoic acid Property

Melting point:

204-206 °C (lit.)

Boiling point:

351.93°C (rough estimate)

Density 

1.683

refractive index 

1.5300 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

ethanol: soluble0.5g/10 mL, clear, yellow to very deep greenish-yellow

form 

Solid

pka

pK1:2.85 (25°C)

color 

Yellow crystalline

PH Range

2.7

Water Solubility 

1350 mg/L (25 ºC)

Merck 

14,3276

BRN 

1914286

Stability:

Stable. Contact with strong bases may lead to fire. Incompatible with strong bases, strong oxidizing agents.

LogP

1.51 at 20℃

CAS DataBase Reference

99-34-3(CAS DataBase Reference)

NIST Chemistry Reference

Benzoic acid, 3,5-dinitro-(99-34-3)

EPA Substance Registry System

3,5-Dinitrobenzoic acid (99-34-3)

Safety

Hazard Codes 

Xn,F

Risk Statements 

22-36/37/38-68-11

Safety Statements 

26-36/37/39-16

RIDADR 

UN1325

WGK Germany 

3

RTECS 

DG9140700

TSCA 

Yes

HazardClass 

4.1

PackingGroup 

III

HS Code 

29163900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3,5-Dinitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow monoclinic prismatic crystal. Soluble in alcohol and glacial acetic acid, slightly soluble in water, ether and carbon disulfide. Can be volatile with water vapor.

Uses

3,5-nitrobenzoic acid is an important intermediate for organic synthesis, in the pharmaceutical industry for the synthesis sulfachrysoidine and for the detection of ampicillin.

Uses

3,5-Dinitrobenzoic acid, is used as a reagent used in the derivatization of resins and the determination of ampicillin.

Preparation

3,5-Dinitrobenzoic acid is synthesized by nitration of benzoic acid. Sulfuric acid was added to the dry reaction pot, and benzoic acid was added under stirring. Heat to 60°C, add fuming nitric acid dropwise, and complete the dropwise addition below 85°C. React at 80-85°C for 1 h, 100°C for 0.5-1h, and then heat up to 135°C for 2h. Leave overnight. The reaction solution was put into ice water to separate out crystals, filtered, washed with water and then washed with 50% ethanol to obtain 3,5-dinitrobenzoic acid. Yield 70%.

Application

3,5-Dinitrobenzoic Acid is used in fluorometric analysis of creatinine (which is a determinant of kidney function). Also used as a reagent in the synthesis of several organic compounds including that of rhodanine derivatives that act as aldose reductase inhibitors.

Definition

ChEBI: 3,5-dinitrobenzoic acid is a member of the class of benzoic acids that is benzoic acid in which the hydrogens at positions 3 and 5 are replaced by nitro groups. It is a C-nitro compound and a member of benzoic acids.

General Description

3,5-Dinitrobenzoic acid forms an adduct with 3,5-dimethylpyridine and the crystal structure of adduct has been studied at room temperature and 80K for both undeuterated and deuterated compounds. It forms 1:1 cocrystal with analgesic drug, ethenzamide and exists in two polymorphic forms.

Purification Methods

Crystallise the acid from distilled H2O or 50% EtOH (4mL/g). Dry it in a vacuum desiccator or at 70o over BaO under a vacuum for 6hours. [Beilstein 9 II 279, 9 III 1779, 9 IV 1242.]