3-(Trifluoromethyl)cinnamic acid

Product Name: 3-(Trifluoromethyl)cinnamic acid
CAS No.: 779-89-5
Chemical Name: 3-(Trifluoromethyl)cinnamic acid
Synonyms: 3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID;MTF-CNA;Cinacalcet-27;TIMTEC-BB SBB000553;RARECHEM BK HW 0018;CINMIC ACID IMPURITY;Cinacalcet Impurity 40;3-[3-(Trifluoromethyl)Pheny;m-(Trifluoromethyl)Cinnamic;3-rifluoromethyl)CinnamicAcid
CBNumber: CB8295905
Molecular Formula: C10H7F3O2
Formula Weight: 216.16
MOL File: 779-89-5.mol

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3-(Trifluoromethyl)cinnamic acid Property

Melting point:: 135-137 °C(lit.)
Boiling point:: 224°C (rough estimate)
Density: 1.3275 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.25±0.10(Predicted)
color: White to Off-White
BRN: 1963372
InChI: InChI=1S/C10H7F3O2/c11-10(12,13)8-3-1-2-7(6-8)4-5-9(14)15/h1-6H,(H,14,15)
InChIKey: KSBWHDDGWSYETA-UHFFFAOYSA-N
SMILES: C(O)(=O)C=CC1=CC=CC(C(F)(F)F)=C1
CAS DataBase Reference: 779-89-5(CAS DataBase Reference)
EPA Substance Registry System: 3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-37/38
Safety Statements: 26-37/39-37
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1547
Product name: 3-(Trifluoromethyl)cinnamic Acid
Purity: >99.0%(GC)(T)
Packaging: 5g
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: T1547
Product name: 3-(Trifluoromethyl)cinnamic Acid
Purity: >99.0%(GC)(T)
Packaging: 25g
Price: $340
Updated: 2025/07/31

TRC

Product number: T791225
Product name: 3-(Trifluoromethyl)cinnamic Acid
Packaging: 1g
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK954997
Product name: 3-(Trifluoromethyl)cinnamic Acid
Purity: 99%
Packaging: 5g
Price: $48
Updated: 2021/12/16

Apolloscientific

Product number: PC7663
Product name: 3-(Trifluoromethyl)cinnamic Acid
Purity: 98%
Packaging: 100g
Price: $63
Updated: 2021/12/16

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3-(Trifluoromethyl)cinnamic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.

Uses

3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.

Definition

ChEBI: (E)-3-(trifluoromethyl)cinnamic acid is a member of the class of (trifluoromethyl)benzenes consisting of trans-cinnamic acid having a trifluoromethyl substituent at the meta-position. It is a member of cinnamic acids, a member of styrenes and a member of (trifluoromethyl)benzenes. It is functionally related to a trans-cinnamic acid.

Synthesis

To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.

3-(Trifluoromethyl)cinnamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(Trifluoromethyl)cinnamic acid Suppliers

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View Lastest Price from 3-(Trifluoromethyl)cinnamic acid manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: 3-(Trifluoromethyl)cinnamic acid 779-89-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: Purity: 99%
Supply Ability: 50tons
Release date: 2025-07-21

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3-(Trifluoromethyl)cinnamic acid 779-89-5
Price: US $999.00-666.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-09

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-(Trifluoromethyl)cinnamic acid 779-89-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

779-89-5, 3-(Trifluoromethyl)cinnamic acidRelated Search:

Cinnamaldehyde 3-Trifluoromethylphenol 3-(Trifluoromethyl)phenylacetone Trifluoromethanesulfonic acid 3-Aminobenzotrifluoride 3-Bromobenzotrifluoride Cinnamic acid (Trifluoromethyl)trimethylsilane 3-(Trifluoromethyl)benzoic acid 4-(Trifluoromethyl)benzaldehyde 3-Chloromethyl-benzotrifluoride Ethyl 2-(Chlorosulfonyl)acetate 3'-(Trifluoromethyl)acetophenone 3-Chlorocinnamic acid alpha-Methylcinnamic acid Glycine Folic acid 3-(Trifluoromethyl)benzaldehyde

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3-[3-(TRIFLUOROMETHYL)PHENYL]ACRYLIC ACID

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3-rifluoromethyl)CinnamicAcid,m-trifluoromethyl cinnamic acid,RARECHEM BK HW 0018,MTF-CAN

CINMIC ACID IMPURITY

3-(Trifluoromethyl)cinnamic acid, predominantly <i>trans</i>

3-TRIFLUROMETHYL CINNAMIC ACID

779-89-5

799-89-5

C10H6F3O2

Organic Building Blocks

Building Blocks

C10

Carbonyl Compounds

Carboxylic Acids

Aromatics

Inhibitors

C10

Carbonyl Compounds

Carboxylic Acids

Miscellaneous

Aromatics Compounds

Aromatic Cinnamic Acids, Esters and Derivatives

779-89-5

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