4-(Trifluoromethyl)-2'-biphenylcarboxylic acid
- Product Name
- 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid
- CAS No.
- 84392-17-6
- Chemical Name
- 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid
- Synonyms
- BW-207U;xenalipin;Xenalipine;AKOS BAR-0249;RARECHEM AL BO 1014;Chemical raw materials;4-(2-Carboxyphenyl)benzotrifluoride;2-[4-(trifluoromethyl)phenyl]benzoate;4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBOXYLIC ACID;4’-Trifluoromethyl-2-biphenyl carboxylic acid
- CBNumber
- CB8296038
- Molecular Formula
- C14H9F3O2
- Formula Weight
- 266.22
- MOL File
- 84392-17-6.mol
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid Property
- Melting point:
- 169-171 °C(lit.)
- Boiling point:
- 335.8±37.0 °C(Predicted)
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.70±0.36(Predicted)
- color
- White to Almost white
- BRN
- 7577560
- CAS DataBase Reference
- 84392-17-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29162090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 346357
- Product name
- 4′-(Trifluoromethyl)-2-biphenylcarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $32
- Updated
- 2023/06/20
- Product number
- 346357
- Product name
- 4′-(Trifluoromethyl)-2-biphenylcarboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $69
- Updated
- 2023/06/20
- Product number
- T3231
- Product name
- 4'-(Trifluoromethyl)biphenyl-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- T3231
- Product name
- 4'-(Trifluoromethyl)biphenyl-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- B25099
- Product name
- 4'-(Trifluoromethyl)biphenyl-2-carboxylic acid, 98%
- Packaging
- 5g
- Price
- $126
- Updated
- 2021/12/16
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Originator
Xenalipin ,Wellcome (GSK)
Uses
Hypolipidemic.
Uses
4''-(Trifluoromethyl)-2-biphenylcarboxylic Acid, is a novel compound which has been found to be effective hypolipidemic agent in animal species. It is also an intermediate in the synthesis of various pharmaceutical compounds, such as Cannabinol (C175350).
Manufacturing Process
a). Preparation of 2-(4,4-dimethyl-2-oxazolin-2-yl)-4'-trifluoromethylbiphenyl:
A mechanically stirred solution of magnesium turnings (5.1 g, 0.21 mole)
Mallinckrodt, for Grignards reaction, and 2-(2-methoxyphenyl)-4,4-dimethyl-
2-oxazoline (41 g, 0.2 mole) in 50 mL dry tetrahydrofuran under nitrogen was
prepared. To this was added a crystal of iodine, 1 mL of dibromethane and 2
mL of neat p-bromotrifluoromethylbenzene to initiate the Grignard reaction.
Following initiation of the reaction, the remainder of the p-
bromotrifluoromethylbenzene (50 g, 0.22 mole total) in 100mL dry
tetrahydrofuran was added dropwise at a rate sufficient to maintain the
reaction at gentle reflux. The addition took 1 hour. At the end of the addition
period, the reaction mixture was heated to reflux for 3 hours. The reaction
mixture was then cooled to room temperature and 10 mL water was added
dropwise to coagulate the salts. The tetrahydrofuran was decanted and the
remaining solids were slurried twice with 300 mL ethyl ether and twice with
300 mL dichloromethane. Each organic extract was decanted from the solids
in turn and combined and evaporated under reduced pressure to an oil.
This oil was redissolved in 300 mL dichloromethane, washed once with 100
mL water and once with 10 mL saturated sodium chloride solution, dried and
concentrated under reduced pressure. The resulting residue was distilled
under reduced pressure (0.040 mm, 95.degree.) to yield 2-(4,4-dimethyl-2-
oxazoline-2-yl)-4'-trifluoromethylbiphenyl, yield 33%. A sample was
recrystallized from 30-60°C petroleum ether (melting point 50-51°C).
b). Preparation of 4'-(trifluoromethyl)-2-biphenylcarboxylic acid:
A solution of 2-(4,4-dimethyl-2-oxazolin-2-yl)-4'-trifluoromethylbiphenyl (3.5
g, 0.011 mole) in 60 mL 6 N hydrochloric acid was stirred at vigorous reflux
for 2 hr. The reaction mixture was then cooled to room temperature and
extracted with methylene chloride. The organic extracts were dried and
concentrated under reduced pressure to yield a solid. Recrystallisation from
ethyl ether/pentane afforded 4'-(trifluoromethyl)-2-biphenyl carboxylic acid,
yield 86% (melting point 167-169°C).
Therapeutic Function
Antihyperlipidemic
General Description
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been tested as an effective hypolipidemic agent in animal species. It has been shown to cause significant reduction in serum cholesterol and triglyceride levels in animal models and would be beneficial in therapy for hyperlipidemia. Synthesis of 4′-(trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been reported. Xenalipin has been synthesized in the [14C]-labelled form, with specific activity 21.0mCi/mmol, which is suitable for the metabolism and distribution studies in animals.
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid manufacturers
- Product
- 4-(Trifluoromethyl)-2"-biphenylcarboxylic acid 84392-17-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-(Trifluoromethyl)-2"-biphenylcarboxylic acid 84392-17-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- 4-(Trifluoromethyl)-2'-biphenylcarboxylic acid 84392-17-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-06