ChemicalBook > CAS DataBase List > Acid Red 94

Acid Red 94

Product Name
Acid Red 94
CAS No.
632-69-9
Chemical Name
Acid Red 94
Synonyms
ROSE BENGAL;RB;BENGAL ROSE;ROSE BENGAL SODIUM SALT;ROSE BENGAL DISODIUM SALT;ROSE BENGALE;CI 45440;Rose red;TNF-α ELISA;4,5,6,7-tetrachloro-2’,4’,5’,7’-tetraiodo-fluoresceidisodiumsalt
CBNumber
CB8300775
Molecular Formula
C20H5Cl4I4NaO5
Formula Weight
997.66
MOL File
632-69-9.mol
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Acid Red 94 Property

Melting point:
>300°C
storage temp. 
Store at +15°C to +30°C.
solubility 
H2O: soluble1mg/mL
Colour Index 
45440
form 
Solid
pka
3.9, 4.7(at 25℃)
color 
Red-brown
Water Solubility 
soluble
Sensitive 
Light Sensitive
λmax
548 nm
Merck 
14,8262
BRN 
3645857
Biological Applications
Apoptosis assay; diagnosis of diseases related to amyloid accumulation; controlling plant diseases; identifying fungi; treating skin,mouth,digestive tract,urinary tract,reproductive tract,respiratory tract,circulatory system
CAS DataBase Reference
632-69-9(CAS DataBase Reference)
EPA Substance Registry System
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt (632-69-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/38
Safety Statements 
22-24/25-37/39-26
RIDADR 
UN 3264 8 / PGIII
WGK Germany 
3
RTECS 
LM5920000
F 
8
TSCA 
Yes
HS Code 
32129000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H290May be corrosive to metals

Precautionary statements

P234Keep only in original container.

P390Absorb spillage to prevent material damage.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
RAB1898
Product name
Rat E-Selectin ELISA
Purity
for serum, plasma and cell culture supernatants
Packaging
96WELLS
Price
$869
Updated
2024/03/01
Sigma-Aldrich
Product number
RAB1187
Product name
Bovine IGF-1 ELISA
Purity
for serum, plasma and cell culture supernatants
Packaging
96wells
Price
$635
Updated
2024/03/01
Sigma-Aldrich
Product number
198250
Product name
Rose bengal
Purity
certified by the Biological Stain Commission, Dye content ≥80%
Packaging
5g
Price
$35.3
Updated
2024/03/01
Sigma-Aldrich
Product number
198250
Product name
Rose bengal
Purity
certified by the Biological Stain Commission, Dye content ≥80%
Packaging
25g
Price
$119
Updated
2024/03/01
TCI Chemical
Product number
F0001
Product name
Food Red No. 105
Packaging
25g
Price
$144
Updated
2024/03/01
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Acid Red 94 Chemical Properties,Usage,Production

Description

Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer. It exhibits absorption/emission maxima of 548/567 nm, respectively. Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM. It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark. It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.

Chemical Properties

bordeaux-red to red-brown crystalline powder

Uses

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Uses

Rose Bengal Sodium Salt is used in biological studies as potential for use as sensitizers in photodynamic and sonodynamic therapy by synthesizing Rose Bengal amphiphilic derivatives. This compound has neuroprotective properties.

General Description

This ELISA antibody pair detects Bovine IGF-1

Safety Profile

An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic fumes of Cl-, I-, and NazO.

Veterinary Drugs and Treatments

Rose bengal is a vital stain and stains dead epithelial cells and mucus. Full thickness loss of the corneal epithelium is not necessary (only dead cells need be present) to obtain rose bengal stain uptake. It does not stain epithelial defects and does not pass into intercellular spaces.
Rose bengal stain is most commonly employed in the detection of the presence of viral keratitis in the cat. Because feline herpes virus tends to infect one cell, moving then to an adjacent cell (causing the so called dendritic tracts in the cornea) without full thickness loss of corneal epithelium initially, rose bengal is an ideal diagnostic agent for this infection. Rose Bengal can also be used to detect damaged corneal epithelium on the dorsal cornea in early cases of keratoconjunctivitis sicca. Rose bengal stain is virucidal although no information is available relative to its use as a therapeutic agent.

in vitro

rose bengal was a quite potent membrane-permeant inhibitor of glutamate uptake into isolated synaptic vesicles. such vesicular glu uptake inhibition was achieved without affecting h1-pump atpase. it was found that various degrees of reduction elicited by rose bengal in [3h]glu in synaptic vesicles inside the synaptosome [1].

in vivo

the distribution of i.v. administered rose bengal was found to depend on its dose. at a low dose, rose bengal could be found almost solely in the liver and plasma. however, at higher doses, the amount of rose bengal found in extra-hepatic tissues gradually increased. the hepatic transfer maximum of rose bengal amounted to 146 micrograms/kg/min. by increasing the dose from 10 to 200 mg/kg, the hepatic concentration of rose bengal also approached a maximum. the storage capacity of the liver, however, did not limit the transfer maximum of rose bengal [1].

storage

Store at RT

Purification Methods

This biological stain can be purified by chromatography on silica TLC using a 35:65 mix of EtOH/acetone as eluent. [Beilstein 19 II 261, 19 III/IV 2926.]

References

[1] ogita k,hirata k,bole dg,yoshida s,tamura y,leckenby am,ueda t. inhibition of vesicular glutamate storage and exocytotic release by rose bengal. j neurochem.2001 apr;77(1):34-42.
[2] fischer e,varga f. hepatic storage and biliary excretion of rose bengal in the rat. acta physiol acad sci hung.1979;54(1):89-94.

Acid Red 94 Preparation Products And Raw materials

Raw materials

Tetrachlorofluorescein Phosphate Buffer solution Electrophoresis Sodium chloride LB Acid Red 92

Preparation Products

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View Lastest Price from Acid Red 94 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Acid Red 94 632-69-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg/month
Release date
2021-07-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
Rose Bengal sodium salt 632-69-9
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22
Career Henan Chemical Co
Product
rose bengal sodium 632-69-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

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