GSK-2256098
- Product Name
- GSK-2256098
- CAS No.
- 1224887-10-8
- Chemical Name
- GSK-2256098
- Synonyms
- CS-2424;GTPL7939;GSK-2256099;GSK-2256098;GSK-2256098, GTPL7939;GSK-2256098;GSK 2256098;FAK inhibitor GS2256098;2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide;2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide;Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-
- CBNumber
- CB83044319
- Molecular Formula
- C20H23ClN6O2
- Formula Weight
- 414.89
- MOL File
- 1224887-10-8.mol
GSK-2256098 Property
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM)
Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM) - form
- A crystalline solid
- pka
- 5.24±0.10(Predicted)
- InChI
- InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
- InChIKey
- BVAHPPKGOOJSPU-UHFFFAOYSA-N
- SMILES
- C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 22955
- Product name
- GSK2256098
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 22955
- Product name
- GSK2256098
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 22955
- Product name
- GSK2256098
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- 22955
- Product name
- GSK2256098
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $412
- Updated
- 2024/03/01
- Product number
- G797530
- Product name
- GSK2256098
- Packaging
- 2.5mg
- Price
- $145
- Updated
- 2021/12/16
GSK-2256098 Chemical Properties,Usage,Production
Description
GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC50s = 15, 8.5, and 12 nM, respectively). It induces apoptosis and increases PARP levels, decreases viability (IC50 = 25 μM), and inhibits colony formation in L3.6P1 cells. GSK2256098 (75 mg/kg per day) also leads to lower tumor weight and fewer metastases in the Ishikawa orthotopic mouse model of uterine cancer.
Uses
GSK 2256098 is FAK inhibitor. It can be used in biological study of molecular pathways: endothelial cell FAK-?A target for cancer treatment.
storage
Store at -20°C