MEPENZOLATE BROMIDE

Product Name: MEPENZOLATE BROMIDE
CAS No.: 76-90-4
Chemical Name: MEPENZOLATE BROMIDE
Synonyms: jb340;Colum;cantil;cantril;Delevil;Eftoron;Cantilon;NSC 4358;Colopiril;Trancolon
CBNumber: CB8305871
Molecular Formula: C21H26BrNO3
Formula Weight: 420.34
MOL File: 76-90-4.mol

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MEPENZOLATE BROMIDE Property

Melting point:: 228-229°C dec.
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form: Solid
color: White to Off-White

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: TN5710000
Toxicity: LD50 orally in rats: 742±47 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M5651
Product name: Mepenzolate bromide
Purity: analytical standard
Packaging: 5g
Price: $77.4
Updated: 2024/03/01

Cayman Chemical

Product number: 23717
Product name: Mepenzolate (bromide)
Purity: ≥95%
Packaging: 500mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23717
Product name: Mepenzolate (bromide)
Purity: ≥95%
Packaging: 1g
Price: $48
Updated: 2024/03/01

TRC

Product number: M223750
Product name: Mepenzolate bromide
Packaging: 5g
Price: $340
Updated: 2021/12/16

Usbiological

Product number: M2908
Product name: Mepenzolate Bromide
Packaging: 5g
Price: $403
Updated: 2021/12/16

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MEPENZOLATE BROMIDE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Cantil,Merrell National,US,1956

Uses

Used as an anticholinergic

Definition

ChEBI: Mepenzolate bromide is a diarylmethane.

Manufacturing Process

A mixture containing 8 g (0.06 mol) of N-methyl-3-chloro-piperidine and 13.6 g (0.06 mol) of benzilic acid in 50 cc of anhydrous isopropyl alcohol was refluxed for 3 days; the isopropyl alcohol was removed by distillation in vacuo, the residue treated with dilute aqueous hydrochloric acid and the aqueous acid mixture extracted repeatedly with ether. The aqueous phase was separated, made strongly alkaline with 20% aqueous sodium hydroxide and extracted with ether. The ether extracts were dried with potassium carbonate and distilled; the product was collected at 175° to 176°C (0.03 mm), yield 11.5 g (59 %).The ester base thus prepared was then dissolved in 75 cc of isopropyl alcohol and 3.4 g (0.037 mol) methyl bromide added. The reaction mixture was allowed to stand at 30°C for 2 days and the product isolated by filtration, yield, 13 g (87%), MP 228° to 229°C dec.

Therapeutic Function

Spasmolytic

General Description

Mepenzolate bromide, 3-hydroxy-1,1-dimethylpiperidinium bromide benzilate (Cantil),has an activity about one half that of atropine in reducingACh-induced spasms of the guinea pig ileum. The selectiveaction on colonic hypermotility is said to relieve pain, cramps,and bloating and to help curb diarrhea.

Pharmacology

Mepenzolate inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used in place of other drugs for treating stomach ulcers and inflammation of the intestine. Synonyms of this drug are cantil and eftoron.

Synthesis

Mepenzolate, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl piperidinium bromide (14.1.13), is synthesized by esterification of benzilic acid with 1-methyl-3- chloropiperidine and subsequent reaction of the resulting ester (14.1.12) with methyl bromide [14,15].

MEPENZOLATE BROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MEPENZOLATE BROMIDE Suppliers

Canada 1 China 54 Germany 2 India 3 Switzerland 1 United Kingdom 4 United States 23 Global 88

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View Lastest Price from MEPENZOLATE BROMIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: MEPENZOLATE BROMIDE 76-90-4
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-04

Career Henan Chemical Co

Product: (1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide 76-90-4
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

76-90-4, MEPENZOLATE BROMIDERelated Search:

2-(2-HYDROXYPHENYL)PROPIONIC ACID Methyl 2-hydroxyisobutyrate Methyl benzilate 2-Phenyl-1,2-propanediol (R)-(-)-2-HYDROXY-2-PHENYLPROPIONIC ACID ETHYL MANDELATE 2,2-Diphenylacetic acid BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE (S)-(+)-Methyl mandelate Clidinium bromide Butyl lactate Ethyl 2-hydroxyisobutyrate MEPENZOLATE BROMIDE METHACHOLINE BROMIDE ISOPROPYL (S)-(-)-LACTATE 3-METHOXYPIPERIDINE ETHYL (R)-(-)-MANDELATE L-(+)-MANDELIC ACID ETHYL ESTER

benzilicacid,1-methyl-3-piperidylestermethobromide

benzilicacid,esterwith3-hydroxy-1,1-dimethylpiperidiniumbromide

gastropidil

jb340

mepenzolate

n-methyl-3-piperidylbenzilatemethobromide

n-methyl-3-piperidylbenzilatemethylbromide

n-methyl-3-piperidyldiphenylglycolatemethobromide

piperidinium,3-hydroxy-1,1-dimethyl-,bromide,benzilate

(1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide

cantil

cantril

MEPENZOLATE BROMIDE

3-[(HYDROXY-DIPHENYLACETYL)OXY]-1,1-DIMETHYLPIPERIDINIUM BROMIDE

3-HYDROXY-1,1-DIMETHYLPIPERIDINIUM BROMIDE BENZILATE

3-benziloyloxy-1,1-dimethylpiperidinium bromide

1-Methyl-3-piperidyl benzilate methylbromide

3-Hydroxy-1,1-dimethylpiperidinium bromide benzilate (6CI, 7CI)

Cantilaque

Cantilon

Colibantil

Colopiril

Colum

Delevil

NSC 4358

Piperidinium, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl-, bromide (9CI)

Piperidinium, 3-hydroxy-1,1-dimethyl-, bromide, benzilate (8CI)

Trancolon

Atenecolin-M

Eftoron

Mepenzolate Bromide (200 mg)

3-(2-Hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium bromide

HCAR2,PUMA-G,inhibit,Muscarinic acetylcholine receptor,Inhibitor,hM3R,gastrointestinal,Chronic,HCA2,muscarinic,HM74A,mAChR,orally,pulmonary,COPD,Mepenzolate Bromide,obstructive,GPR109A,Mepenzolate,bronchodilatory,hypermotility,anti-inflammatory,hM2R

Piperidinium, 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-, bromide (1:1)

76-90-4

C21H26BrNO3

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Analytical Chromatography Product Catalog

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MEA - MES

CANTIL

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