ML291

Product Name: ML291
CAS No.: 1523437-16-2
Chemical Name: ML291
Synonyms: ML291;ML291 >=98% (HPLC);2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-
CBNumber: CB83134603
Molecular Formula: C16H16ClN3O6S
Formula Weight: 413.83
MOL File: 1523437-16-2.mol

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ML291 Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤1mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid
pka: 11.24±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19831
Product name: ML-291
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 19831
Product name: ML-291
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 19831
Product name: ML-291
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 19831
Product name: ML-291
Purity: ≥98%
Packaging: 25mg
Price: $356
Updated: 2024/03/01

AK Scientific

Product number: 1360DJ
Product name: N-[4-(4-Chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide
Packaging: 25mg
Price: $495
Updated: 2021/12/16

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ML291 Chemical Properties,Usage,Production

Biological Activity

ml-291 is an apoptosis inducer.apoptosis, a process of programmed cell death, occurs in multi-cellular organisms. biochemical events result in characteristic cell changes (morphology) and death. these changes include cell shrinkage, nuclear fragmentation, blebbing, chromatin condensation, chromosomal dna fragmentation, as well as global mrna decay.

in vitro

ml-291 was identified as a novel activator of the apoptotic arm of the unfolded protein response (upr), but not the adaptive arm. specifically, ml-291 could activate signaling via perk/eif2α/chop with ec50 value of 762 nm but not through ire1/xbp1. moreover, ml-291 induced apoptosis in mouse embryonic fibroblasts overexpressing chop, but not in wild-type or chop knockout cells. ml-291 showed minimal activity against a panel of 67 receptors, ion channels, as well as transporters, with the exception of the dopamine transporter with 68% inhibition. in addition, ml-291 showed greater cytotoxicity than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an nci-60 panel [1].

References

[1] flaherty, d. p.,golden, j.e.,liu, c., et al. selective small molecule activator of the apoptotic arm of the upr. probe reports from the nih molecular libraries program (2012).

ML291 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML291 Suppliers

China 15 United States 3 Global 18

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4597
Advantage: 55

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4180
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6813
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

1523437-16-2, ML291Related Search:

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ML291

ML291 >=98% (HPLC)

2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-

1523437-16-2

C16H16ClN3O6S