ML246

Product Name: ML246
CAS No.: 1443414-10-5
Chemical Name: ML246
Synonyms: ML246;Metarrestin (ML246);Metarrestin (ML246) ，S3472;Metarrestin, 10 mM in DMSO;trans-4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol;trans-4-(7-Benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol;Cyclohexanol, 4-[4,7-dihydro-4-imino-5,6-diphenyl-7-(phenylmethyl)-3H-pyrrolo[2,3-d]pyrimidin-3-yl]-, trans-;ML-246,breast,perinucleolar,HeLa,Metarrestin,nucleolar,Inhibitor,DNA/RNA Synthesis,PANC1,orally,metastatic,transcription,inhibit,eEF1A2,PC3M,compartment,pancreatic,ML 246
CBNumber: CB84718639
Molecular Formula: C31H30N4O
Formula Weight: 474.6
MOL File: 1443414-10-5.mol

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ML246 Property

Boiling point:: 651.7±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 31.25 mg/mL (65.84 mM)
form: Solid
pka: 14.93±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M425380
Product name: ML246
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0069520
Product name: Metarrestin
Purity: 99.85%
Packaging: 10mg
Price: $290
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BM166959
Product name: Metarrestin NEW
Packaging: 10mg
Price: $375
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BM166959
Product name: Metarrestin NEW
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0069520
Product name: Metarrestin
Purity: 99.85%
Packaging: 25mg
Price: $580
Updated: 2021/12/16

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ML246 Chemical Properties,Usage,Production

Uses

ML246 is a perinucleolar compartment (PNC) modulator/ Inhibitor.

in vivo

Metarrestin (ML246; 5-25 mg/kg; IP; once daily; continuing for six weeks) displays a decrease in metastatic burden in both liver (p <0.01) and lung with 25 mg/kg^[2].
? Metarrestin (drug-infused chow; 10 mg/kg; 70 ppm) extends survival in the NSG PANC1 pancreatic cancer metastasis mice model^[2].
? Metarrestin (5, 25 mg/kg; ip; for 4 additional week) reduces metastasis of prostate cancer (PC3M) and growth of metastatic breast cancer PDX mice models^[2].
? Metarrestin (5 and 25 mg/kg; IP) has a half-life of 4.6 to 5.5 hours^[2].

Animal Model:	NOD/IL2 gamma (null) PANC1 mice over primary tumor tissues^[2]
Dosage:	5 and 25 mg/kg
Administration:	IP; once daily; continuing for six weeks
Result:	Displayed a decrease in metastatic burden in both liver (p <0.01) and lung with 25 mg/kg. Demonstrated a significant reduction of perinucleolar compartment prevalence in metastatic and primary tumor tissues.

Animal Model:	Female BALB/c mice^[2]
Dosage:	5 and 25 mg/kg (Pharmacokinetic Analysis)
Administration:	IP
Result:	Indicated good exposure, distribution, and tolerability in vivo, with a half-life of 4.6 to 5.5 hours.

ML246 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML246 Suppliers

China 52 United States 4 Global 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

1443414-10-5, ML246Related Search:

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ML246

Metarrestin (ML246)

Cyclohexanol, 4-[4,7-dihydro-4-imino-5,6-diphenyl-7-(phenylmethyl)-3H-pyrrolo[2,3-d]pyrimidin-3-yl]-, trans-

trans-4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol

ML-246,breast,perinucleolar,HeLa,Metarrestin,nucleolar,Inhibitor,DNA/RNA Synthesis,PANC1,orally,metastatic,transcription,inhibit,eEF1A2,PC3M,compartment,pancreatic,ML 246

trans-4-(7-Benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol

Metarrestin, 10 mM in DMSO

Metarrestin (ML246) ，S3472

1443414-10-5