ML349

Product Name: ML349
CAS No.: 890819-86-0
Chemical Name: ML349
Synonyms: ML349;ML349 >=98% (HPLC);ML349, 10 mM in DMSO;ML349,Inhibitor,ML 349,inhibit,Phospholipase,ML-349;(5,5-Dioxido-4H-thieno[3,2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone;(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone;Methanone, (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-
CBNumber: CB63386499
Molecular Formula: C23H22N2O4S2
Formula Weight: 454.56
MOL File: 890819-86-0.mol

More

Less

ML349 Property

storage temp.: Store at -20°C
solubility: DMSO : 20 mg/mL (44.00 mM; Need ultrasonic)
form: Powder
color: White to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1918
Product name: ML349
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95.4
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML1918
Product name: ML349
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $387
Updated: 2022/05/15

Cayman Chemical

Product number: 20923
Product name: ML-349
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20923
Product name: ML-349
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 20923
Product name: ML-349
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

More

Less

ML349 Chemical Properties,Usage,Production

Uses

ML 349 is an inhibitor of lysophospholipase 2 (LYPLA2), a serine hydrolase, and displays an isoform selective inhibition of acyl protein thioesterases.

Biological Activity

ML349 is a substrate-competitive, reversible and APT2-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 510 nM/230 nM against APT2; IC50 & Ki >10 μM against APT1). ML349 effectively inhibits cellular APT2 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT1. ML349 treatment (5 μM) is shown to restore palmitoylation and membrane localization of the multidomain scaffolding protein Scribble (Scrib) in MDCK cells overexpressing the epithelial-to-mesenchymal transcription factor (EMT-TF) Snail.

storage

Store at +4°C

ML349 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ML349 Suppliers

China 55 United Kingdom 1 United States 8 USA 1 Global 65

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2998
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

Zhaoqing Wanwei New Material Technology Co., Ltd.

Tel: 0755-1328880-4488 13068786899
Fax: 13068786899
Email: 13288804488@163.com
Country: China
ProdList: 625
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

890819-86-0, ML349Related Search:

ML291 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a] ML318 ML355 ML198 ML402 1-(4-(4-(benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethan-1-one 2-(3,4-dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide ML-228 ML-098 [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone Nodinitib-1 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)- ML385 ML365 ML337 8-ethyl-5-oxo-2-[4-[[3-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]pyrido[2,3-d]pyrimidine-6-carboxylic acid ML246

ML349

(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone

Methanone, (5,5-dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]-

ML349 >=98% (HPLC)

ML349,Inhibitor,ML 349,inhibit,Phospholipase,ML-349

(5,5-Dioxido-4H-thieno[3,2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone

ML349, 10 mM in DMSO

890819-86-0