ML291
- Product Name
- ML291
- CAS No.
- 1523437-16-2
- Chemical Name
- ML291
- Synonyms
- ML291;ML291 >=98% (HPLC);2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-
- CBNumber
- CB83134603
- Molecular Formula
- C16H16ClN3O6S
- Formula Weight
- 413.83
- MOL File
- 1523437-16-2.mol
ML291 Property
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤1mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 11.24±0.70(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 19831
- Product name
- ML-291
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 19831
- Product name
- ML-291
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 19831
- Product name
- ML-291
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 19831
- Product name
- ML-291
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 1360DJ
- Product name
- N-[4-(4-Chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide
- Packaging
- 25mg
- Price
- $495
- Updated
- 2021/12/16
ML291 Chemical Properties,Usage,Production
Biological Activity
ml-291 is an apoptosis inducer.apoptosis, a process of programmed cell death, occurs in multi-cellular organisms. biochemical events result in characteristic cell changes (morphology) and death. these changes include cell shrinkage, nuclear fragmentation, blebbing, chromatin condensation, chromosomal dna fragmentation, as well as global mrna decay.
in vitro
ml-291 was identified as a novel activator of the apoptotic arm of the unfolded protein response (upr), but not the adaptive arm. specifically, ml-291 could activate signaling via perk/eif2α/chop with ec50 value of 762 nm but not through ire1/xbp1. moreover, ml-291 induced apoptosis in mouse embryonic fibroblasts overexpressing chop, but not in wild-type or chop knockout cells. ml-291 showed minimal activity against a panel of 67 receptors, ion channels, as well as transporters, with the exception of the dopamine transporter with 68% inhibition. in addition, ml-291 showed greater cytotoxicity than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an nci-60 panel [1].
References
[1] flaherty, d. p.,golden, j.e.,liu, c., et al. selective small molecule activator of the apoptotic arm of the upr. probe reports from the nih molecular libraries program (2012).
ML291 Preparation Products And Raw materials
Raw materials
Preparation Products
ML291 Suppliers
- Tel
- support@targetmol.com
- Country
- United States
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