Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- Product Name
- Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- CAS No.
- 944561-46-0
- Chemical Name
- Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- Synonyms
- CCCH2-PEG3-COOH;Alkyne-PEG2-CH2COOH;Propargyl-PEG2-CH2COOH;Propargyl-PEG3-CH2CO2H;2-[2-(2-prop-2-ynoxyethoxy)ethoxy]acetic acid;2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]acetic acid;2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)acetic acid;Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-;Propargyl-PEG2-CH2COOH/Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- CBNumber
- CB83152069
- Molecular Formula
- C9H14O5
- Formula Weight
- 202.2
- MOL File
- 944561-46-0.mol
Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Property
- Boiling point:
- 334.9±27.0 °C(Predicted)
- Density
- 1.158±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- form
- Liquid
- pka
- 3.39±0.10(Predicted)
- color
- Colorless to light yellow
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- AS104181
- Product name
- Propargyl-PEG2-CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $655
- Updated
- 2021/12/16
- Product number
- 9785DN
- Product name
- 2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)aceticacid
- Packaging
- 500mg
- Price
- $791
- Updated
- 2021/12/16
- Product number
- CS-M3521
- Product name
- Aceticacid,2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
- Packaging
- 1g
- Price
- $850
- Updated
- 2021/12/16
- Product number
- 9785DN
- Product name
- 2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)aceticacid
- Packaging
- 1g
- Price
- $985
- Updated
- 2021/12/16
- Product number
- AS104181
- Product name
- Propargyl-PEG2-CH2COOH
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Chemical Properties,Usage,Production
Description
Propargyl-PEG3-CH2CO2H is an PEG linker with an alkyne and carboxylic acid set of functional groups. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry to form stable triazole linkage. The carboxylic acid can react with primary amines to form stable amide bonds; activator (e.g. EDC, or HATU) is needed.
Uses
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.
Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]- Suppliers
- Tel
- +1-5166625404;
- Fax
- 1-516-927-0118
- Info@alfa-chemistry.com
- Country
- United States
- ProdList
- 20405
- Advantage
- 58
- Tel
- +1-858-6993322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 21193
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58