ACETYLSHIKONIN

ChemicalBook > CAS DataBase List > ACETYLSHIKONIN

Product Name: ACETYLSHIKONIN
CAS No.: 24502-78-1
Chemical Name: ACETYLSHIKONIN
Synonyms: Nsc110199;ACETYLSHIKONIN;Shikonin acetate;Shikonin, acetyl;O-Acetylshikonin;(R)-acetyl shikonin;3-pentenyl]-5,8-dihydroxy-,(R)-;Racemic Acetyl Shikonin Labeled d7;1,4-Naphthalenedione,2-[1-(acetyloxy)-4-methyl-;2,3-dimethoxybenzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CBNumber: CB8317267
Molecular Formula: C18H18O6
Formula Weight: 330.33
MOL File: 24502-78-1.mol

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ACETYLSHIKONIN Property

Melting point:: 86°C
Boiling point:: 553.2±50.0 °C(Predicted)
Density: 1.326±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 7.12±0.20(Predicted)
Stability:: Hygroscopic
LogP: 2.700 (est)
CAS DataBase Reference: 24502-78-1(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Toxicity: mouse,LD50,intraperitoneal,41mg/kg (41mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: ATAXIA,Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 73, Pg. 193, 1977.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 299878
Product name: Acetylshikonin
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA65519
Product name: Acetylshikonin
Packaging: 25mg
Price: $500
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259111
Product name: Acetylshikonin
Purity: 98%
Packaging: 100mg
Price: $654.5
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 74096
Product name: Acetylshikonin
Purity: 98%
Packaging: 20mg
Price: $733
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000350
Product name: ACETYLSHIKONIN
Purity: 95.00%
Packaging: 100MG
Price: $945.95
Updated: 2021/12/16

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ACETYLSHIKONIN Chemical Properties,Usage,Production

Chemical Properties

Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma.

Uses

Acetylshikonin is the main ingredient of Zicao, which has used in clinics as a traditional Chinese for thousands of years. It exerts anti-obesity and anti-NAFLD effects through the regulation of lipid metabolism and anti-inflammatory effects. Also, it is a 1,4-naphthoquinone pigment extracted from the roots of Lithospermum erythrorhizon with anti-tumor effects.

Biological Activity

Acetylshikonin is one naphthoquinone derivative isolated from the Lithospermum erythrorhizon, exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors.
Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated.
Certain shikonin derivatives(such as Acetyl shikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction.
Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats.
Acetylshikonin isolated from Arnebia euchroma (Royle) Johnst cell suspension cultures exhibits specific in vivo and in vitro antitumor effects.
Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge.
Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.

ACETYLSHIKONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ACETYLSHIKONIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: ACETYLSHIKONIN 24502-78-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-30

Shanghai Standard Technology Co., Ltd.

Product: Acetylshikonin 24502-78-1
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-25

Career Henan Chemical Co

Product: ACETYLSHIKONIN 24502-78-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

24502-78-1, ACETYLSHIKONINRelated Search:

Atractylodin Neohesperidosyl dihydrochalcone Kaempferol Myricetin Diosgenin Bengenin Isorhamnetin Taxifolin ARTEMISININ PINOCEMBRIN Alkannin 5,8-Dihydroxy-1,4-naphthoquinone ISOVALERYLSHIKONIN ISOBUTYRYLSHIKONIN (BETA,BETA-DIMETHYLACRYL)SHIKONIN ACETYLSHIKONIN (2-METHYL-N-BUTYRYL)SHIKONIN BETA-HYDROXYISOVALERYLSHIKONIN

(+)-5,8-Dihydroxy-2-[(R)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthoquinone

(R)-1-(1,4-Dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methyl-3-pentenyl=acetate

2-[(R)-1-Acetoxy-4-methyl-3-pentenyl]-5,8-dihydroxy-1,4-naphthoquinone

O-Acetylshikonin

1,4-Naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, 2-acetate, (+)-

Nsc110199

Shikonin, acetyl

Shikonin acetate

(+)-5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone2-acet

4-naphthalenedione,2-(1-(acetyloxy)-4-methyl-3-pentenyl)-5,8-dihydroxy-(

4-naphthoquinone,5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-2-acetate

1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)-

ACETYLSHIKONIN

(R)-1-(5,8-Dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-Methylpent-3-en-1-yl acetate

ACETYLSHIKONIN: 1,4-NAPHTHALENEDIONE,2-[1-(ACETYLOXY)-4-METHYL-3-PENTENYL]-5,8-DIHYDROXY-, (R)-,

1,4-Naphthalenedione,2-[1-(acetyloxy)-4-methyl-

3-pentenyl]-5,8-dihydroxy-,(R)-

Racemic Acetyl Shikonin Labeled d7

2,3-dimethoxybenzoic acid 2-(dimethylamino)ethyl ester hydrochloride

1,4-Naphthalenedione, 2-[(1R)-1-(acetyloxy)-4-methyl-3-penten-1-yl]-5,8-dihydroxy-

(R)-acetyl shikonin

24502-78-1

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