BOC-L-NORLEUCINE

Product Name: BOC-L-NORLEUCINE
CAS No.: 6404-28-0
Chemical Name: BOC-L-NORLEUCINE
Synonyms: BOC-NLE-OH;BOC-L-NLE-OH;BOC-AHX(2)-OH;BOC-NORLEUCINE;BOC-ACPO(2)-OH;BOC-L-NORLEUCINE;N-BOC-L-NORLEUCINE;Boc-Nle-OH (syrup);Boc-L-norleucine99%;RARECHEM EM WB 0164
CBNumber: CB8319221
Molecular Formula: C11H21NO4
Formula Weight: 231.29
MOL File: 6404-28-0.mol

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BOC-L-NORLEUCINE Property

Boiling point:: 373.37°C (rough estimate)
Density: 1.1202 (rough estimate)
refractive index: 1.4425
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.02±0.21(Predicted)
color: Colorless to light yellow
optical activity: [α]20/D 8±1°, c = 1% in methanol
BRN: 3608376
CAS DataBase Reference: 6404-28-0(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15555
Product name: Boc-Nle-OH
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $342
Updated: 2025/07/31

Usbiological

Product number: 236445
Product name: Boc-L-norleucine 99+%
Packaging: 1g
Price: $163
Updated: 2021/12/16

Usbiological

Product number: 264631
Product name: Boc-L-norleucine
Packaging: 2g
Price: $333
Updated: 2021/12/16

ChemScene

Product number: CS-0019199
Product name: Norleucine,N-carboxy-,N-tert-butylester
Packaging: 25g
Price: $138
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB47085
Product name: Boc-L-norleucine
Packaging: 10g
Price: $163.9
Updated: 2021/12/16

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BOC-L-NORLEUCINE Chemical Properties,Usage,Production

Uses

A boc protected amino acid derivative

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

327-57-1

24424-99-5

6404-28-0

The general procedure for the synthesis of N-BOC-L-norleucine from L-norleucine and di-tert-butyl dicarbonate was as follows: free L-norleucine (400 mg, 3.05 mmol) was dissolved in a solvent mixture of water and THF (8.8 mL:8.8 mL), NaHCO3 (768 mg, 9.15 mmol) was added and di-tert-butyl dicarbonate ( 800 mg, 3.66 mmol). The reaction mixture was stirred at 0 °C for 30 min, then gradually warmed to room temperature and continued to stir overnight. Upon completion of the reaction, water (10 mL) was added to dissolve any precipitate that may have formed. Unreacted di-tert-butyl dicarbonate was removed by three extractions with petroleum ether. N-BOC-L-norleucine in the aqueous phase was acidified to pH ≈ 3 with 1 M NaHSO4 solution and subsequently extracted three times with EtOAc. The organic layers were combined and dried with Na2SO4. The solvent was removed by concentration under reduced pressure to give the clear oily product N-BOC-L-norleucine (573 mg, 81% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 12.38 (bs, 1H, COOH), 7.02 (d, J=8.2 Hz, 1H, NH), 3.87-3.78 (m, 1H, CH), 1.69-1.47 (m, 2H, CH2), 1.37 (s, 9H, t-Bu), 1.32- 1.20 (m, 4H, CH2), 0.85 (t, J=7.0Hz, 3H, CH3).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6891 - 6899
[2] Bioorganic and medicinal chemistry letters, 2004, vol. 14, # 1, p. 275 - 278

BOC-L-NORLEUCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-NORLEUCINE Suppliers

Belgium 1 China 107 France 1 Germany 5 India 2 Japan 4 Switzerland 2 United Kingdom 4 United States 15 Global 141

BOC Sciences

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ASDI Incorporated

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Synthetech, Inc.

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MP Biomedicals, Inc.

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Advanced ChemTech

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View Lastest Price from BOC-L-NORLEUCINE manufacturers

Career Henan Chemical Co

Product: BOC-L-NORLEUCINE 6404-28-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

6404-28-0, BOC-L-NORLEUCINERelated Search:

N-BOC-L-Prolinal BOC-ARG-OH N-Boc-L-phenylalaninal (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL BOC-D-ABU-OH N-Boc-L-Phenylalaninol N-Boc-L-tert-Leucine BOC-L-Prolinol N-Boc-L-alaninol Boc-Lys(Boc)-OH BOC-LYS(AC)-OH BOC-LYS(TFA)-OH N-Boc-N'-Cbz-L-lysine BOC-LYS(Z)-OH DCHA Boc-Lys-OH BOC-L-2-AMINOADIPIC ACID N-Boc-N'-Fmoc-L-Lysine BOC-D-NORLEUCINE LIQUID,N-T-BOC-D-NORLEUCINE,BOC-D-NORLEUCINE

(S)-2-((tert-Butoxycarbonyl)aMino)hexanoic acid

N-[(1,1-Dimethylethoxy)carbonyl]-L-norleucine

BOC-L-Norleucine,98%

N-Boc-L-Norleucine (Dry wt.), May Cont. up to ca 10% Solvent

Norleucine, N-carboxy-, N-tert-butyl ester

(Tert-Butoxy)Carbonyl Nle-OH (Syrup)

Boc-(S)-2-aminohexanoicacid

BOC-L-NORLEUCINE

BOC-L-NLE-OH

BOC-L-NHCH[CH3(CH2)3]-COOH

BOC-NLE-OH

BOC-NORLEUCINE

BOC-AHX(2)-OH

BOC-ACPO(2)-OH

BOC-L-2-AMINOCAPROIC ACID

BOC-L-2-AMINOHEXANOIC ACID

(S)-2-(Boc-amino)hexanoic acid

Boc-L-norleucine99%

(S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID

RARECHEM EM WB 0164

N-(TERT-BUTOXYCARBONYL)-L-NORLEUCIN

N-BOC-L-NORLEUCINE

N-ALPHA-T-BOC-L-NORLEUCINE

N-ALPHA-T-BUTOXYCARBONYL-L-2-AMINO-CAPROIC ACID

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-NORLEUCINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-NORLEUCINE

N-ALPHA-T-BUTOXYCARBONYL-L-NORLEUCINE

(s)-2-(boc-amino)caproic acid

N-ALPHA-T-BUTYLOXYCARBONYL-L-NORLEUCINE, (S)-N-ALPHA-BOC-2-AMINOHEXANOIC ACID

BOC-L-NORLEUCINE LIQUID

Boc-L-2-aminohexanoic acid (syrup)

Boc-Nle-OH (syrup)

N-Boc-L-norleucine, 98%(dry wt.), may cont. up to ca 10% solvent

N-(tert-Butoxycarbonyl)norleucine

N-(tert-Butyloxycarbonyl)-L-norleucine

Boc-Nle-OH Boc-Norleucine

L-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-

BOC-L-NORLEUCINE USP/EP/BP

(S)-2-((tertbutyloxyoxo)amino)hexanoic acid

Boc-Nle-OH/99%/6404-28-0

6404-28-0

Unnatural Amino Acid Derivatives

Peptide Synthesis

Norleucine

Specialty Synthesis

Amino Acids