KISS-1 (68-121)

Product Name: KISS-1 (68-121)
CAS No.: 374683-24-6
Chemical Name: KISS-1 (68-121)
Synonyms: METASTIN;KISSPEPTIN-54;KISS-1 (68-121);METASTIN (HUMAN);Kisspeptin(human 54 amino acid variant);MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (68-121) (HUMAN);Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan);Kisspeptin-54 (huMan) Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan);H-GLY-THR-SER-LEU-SER-PRO-PRO-PRO-GLU-SER-SER-GLY-SER-ARG-GLN-GLN-PRO-GLY-LEU-SER-ALA-PRO-HIS-SER-ARG-GLN-ILE-PRO-ALA-PRO-GLN-GLY-ALA-VAL-LEU-VAL-GLN-ARG-GLU-LYS-ASP-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2
CBNumber: CB8319685
Molecular Formula: C258H401N79O78
Formula Weight: 5857.42704
MOL File: 374683-24-6.mol

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KISS-1 (68-121) Property

storage temp.: Desiccate at -20°C
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in Water
Sequence: Gly-Thr-Ser-Leu-Ser-Pro-Pro-Pro-Glu-Ser-Ser-Gly-Ser-Arg-Gln-Gln-Pro-Gly-Leu-Ser-Ala-Pro-His-Ser-Arg-Gln-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1443
Product name: Metastin(human)
Packaging: 100U
Price: $328
Updated: 2021/12/16

Usbiological

Product number: 255793
Product name: Metastin
Packaging: 100ug
Price: $602
Updated: 2021/12/16

ApexBio Technology

Product number: B5114
Product name: Metastin(human)
Packaging: 100ug
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004510
Product name: METASTIN-HUMAN
Purity: 95.00%
Packaging: 5MG
Price: $495.68
Updated: 2021/12/16

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KISS-1 (68-121) Chemical Properties,Usage,Production

Uses

Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone[1][2][3][4][5][6][7][8].

in vivo

Kisspeptin-54(human) (0.3-100 nmol/kg, i.p., 30 min before trunk blood and anterior pituitaries are collected) dose-dependently shows activation of the anterior pituitary release of LH in post-pubertal male rats^[6].
Kisspeptin-54(human) (0.3-30 nmol/kg, i.p.) produces a dose-dependent effect on c-fos mRNA levels in the anterior pituitary in various ages (PND15, PND30, and PND45) male rats^[6].
Kisspeptin-54(human) (0.1-30 nmol/kg, i.p., single) increases serum testosterone in mice, with the same potency as for mouse kisspeptins^[7].
Kisspeptin-54(human) (6.7 nmol/rat, s.c.) induces the release of gonadotropin via activation of the hypothalamic GnRH neurons in prepubertal female rats^[8].

Animal Model:	Post-pubertal male rats^[6]
Dosage:	0.3, 1.0, 3.0, 10, 30 and 100 nmol/kg
Administration:	Intraperitoneal injection (i.p.), 30 min before trunk blood and anterior pituitaries are collected
Result:	Elevated c-fos gene expression, as well as the plasma concentrations of LH and testosterone. Showed no overall statistical effect on plasma testosterone.

storage

Store at -20°C

References

[1] M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145(9):4073-7. DOI:10.1210/en.2004-0431
[2] M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6. DOI:10.1074/jbc.M104847200
[3] Nakamura Y, et al. Metastin stimulates aldosterone synthesis in human adrenal cells. Reprod Sci. 2007 Dec;14(8):836-45. DOI:10.1177/1933719107307823
[4] Masui T, et al. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Feb 27;315(1):85-92. DOI:10.1016/j.bbrc.2004.01.021
[5] Shoji S, et al. Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. European urology, 2009, 55(2): 441-451.
[6] Bentsen AH, et al. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides. 2010 Feb;31(2):275-83. DOI:10.1016/j.peptides.2009.11.017
[7] Mikkelsen JD, et al. Comparison of the effects of peripherally administered kisspeptins. Regul Pept. 2009 Jan 8;152(1-3):95-100. DOI:10.1016/j.regpep.2008.10.001
[8] Matsui H, et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun. 2004 Jul 23;320(2):383-8. DOI:10.1016/j.bbrc.2004.05.185

KISS-1 (68-121) Preparation Products And Raw materials

Raw materials

Preparation Products

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KISS-1 (68-121) Suppliers

China 50 United Kingdom 1 United States 6 Global 57

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd

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Email: shchemsky@sina.com
Country: China
ProdList: 15402
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Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
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Email: info@cellmano.com
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BOC Sciences

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Email: info@bocsci.com
Country: United States
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Nanjing Leon Biological Technology Co., Ltd.

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Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
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Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
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View Lastest Price from KISS-1 (68-121) manufacturers

Career Henan Chemical Co

Product: KISS-1 (68-121) 374683-24-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

374683-24-6, KISS-1 (68-121)Related Search:

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H-GLY-THR-SER-LEU-SER-PRO-PRO-PRO-GLU-SER-SER-GLY-SER-ARG-GLN-GLN-PRO-GLY-LEU-SER-ALA-PRO-HIS-SER-ARG-GLN-ILE-PRO-ALA-PRO-GLN-GLY-ALA-VAL-LEU-VAL-GLN-ARG-GLU-LYS-ASP-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2

MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (68-121) (HUMAN)

Kisspeptin-54 (huMan) Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan)

Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan)

KISS-1 (68-121)

KISSPEPTIN-54

METASTIN

METASTIN (HUMAN)

Kisspeptin(human 54 amino acid variant)

374683-24-6

C258H401N79O78