2-(Dicyclohexylphosphino)biphenyl

ChemicalBook > CAS DataBase List > 2-(Dicyclohexylphosphino)biphenyl

2-(Dicyclohexylphosphino)biphenyl

Reaction

Product Name: 2-(Dicyclohexylphosphino)biphenyl
CAS No.: 247940-06-3
Chemical Name: 2-(Dicyclohexylphosphino)biphenyl
Synonyms: Cy-John-Phos;(2-biphenyl)dicyclohexylphosphine;CYCLOHEXYL JOHNPHOS;dicyclohexyl-(2-phenylphenyl)phosphane;2-(Dicyclo;98% CyJohnPhos;CyJohnPhos 97%;CyJohnPhos CAS;CAS:247940-06-3;Dicyclohexylphosphino)bipheny
CBNumber: CB8325019
Molecular Formula: C24H31P
Formula Weight: 350.48
MOL File: 247940-06-3.mol

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2-(Dicyclohexylphosphino)biphenyl Property

Melting point:: 102-106 °C(lit.)
Boiling point:: 499.5±24.0 °C(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Toluene
form: crystal
color: white
Sensitive: Air Sensitive
BRN: 8440533
InChI: InChI=1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2
InChIKey: LCSNDSFWVKMJCT-UHFFFAOYSA-N
SMILES: P(C1=CC=CC=C1C1=CC=CC=C1)(C1CCCCC1)C1CCCCC1
CAS DataBase Reference: 247940-06-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 36/37/39-26
WGK Germany: 3
F: 10-13-23
TSCA: No
HazardClass: AIR SENSITIVE
HS Code: 29310099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638099
Product name: CyJohnPhos
Purity: 97%
Packaging: 1g
Price: $25.98
Updated: 2024/03/01

Sigma-Aldrich

Product number: 638099
Product name: CyJohnPhos
Purity: 97%
Packaging: 5g
Price: $129
Updated: 2024/03/01

TCI Chemical

Product number: D3388
Product name: 2-(Dicyclohexylphosphino)biphenyl
Purity: >98.0%(GC)
Packaging: 1g
Price: $39
Updated: 2024/03/01

TCI Chemical

Product number: D3388
Product name: 2-(Dicyclohexylphosphino)biphenyl
Purity: >98.0%(GC)
Packaging: 5g
Price: $140
Updated: 2024/03/01

Strem Chemicals

Product number: 15-1140
Product name: 2-(Dicyclohexylphosphino))-1,1'-biphenyl, 98% CyJohnPhos
Packaging: 1g
Price: $31
Updated: 2024/03/01

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2-(Dicyclohexylphosphino)biphenyl Chemical Properties,Usage,Production

Reaction

Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
Ligand employed in Suzuki coupling reactions involving aryl chlorides, bromides and triflates.
Useful ligand for the Pd-catalyzed oxidation of alcohols in the presence of chlorobenzenes.
Useful ligand for the Pd-catalyzed amination with ammonia equivalents.
Ligand for the gold(I)-catalyzed intramolecular [4+2] cycloadditions involving 1,3-enynes and arylalkynes with alkenes.
Ligand used in the palladium-catalyzed borylation of aryl bromdies.
Ligand used in the palladium-catalyzed siliylation of aryl chlorides.

Description

2-(Dicyclohexylphosphino)biphenyl is a ligand for the amination of triflates and aryl halides. Optimal ligand for a novel amination reaction (Buchwald reaction)(2) 2-(Dicyclohexylphosphino)biphenyl, a synthetic chemical compound, has found diverse applications in scientific research. Being a cyclic phosphonate derivative of cyclohexanol, this colourless, odourless, and tasteless solid holds a distinct appeal for laboratory use. In scientific research, 2-(Dicyclohexylphosphino)biphenyl has proven invaluable. It serves as an excellent model compound for delving into protein-ligand interactions, thus aiding in studying small molecule effects on protein folding. Moreover, researchers have utilized 2-(Dicyclohexylphosphino)biphenyl to gain insights into protein structures and unravel the mechanism of action behind various drugs. Additionally, the compound has been a vital tool in assessing how environmental factors influence protein structure and function. The interaction between 2-(Dicyclohexylphosphino)biphenyl and proteins primarily occurs through hydrogen bonding and hydrophobic interactions, resulting in high-affinity and specific protein binding.

Chemical Properties

white to light yellow crystal powde

Uses

Ligand employed in an extremely general method for the Pd-catalyzed synthesis of aromaticamines using aryl chlorides, bromides and triflates.

Uses

suzuki reaction

Uses

2-(Dicyclohexylphosphino)biphenyl is used as a catalyst for Suzuki coupling reactions.

General Description

CyJohnPhos [(2-Biphenyl)dicyclohexylphosphine] is an air-stable, bulky and electron-rich monodentate biarylphosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Hiyama Coupling
reagent type: ligand
reaction type: Methylations
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Oxidations
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

2-(Dicyclohexylphosphino)biphenyl Preparation Products And Raw materials

Raw materials

Bromocyclohexane Nickel(II) chloride hexahydrate Cyclohexane Cinchonidine Diethylamine 2-Bromobiphenyl Bromobenzene Phosphorus trichloride Tetrahydrofuran 1,2-Dibromobenzene Ethyl acetate Copper(I) chloride Dichloromethane Magnesium n-Butyllithium

Preparation Products

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2-(Dicyclohexylphosphino)biphenyl Suppliers

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View Lastest Price from 2-(Dicyclohexylphosphino)biphenyl manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 2-(Dicyclohexylphosphino)biphenyl 247940-06-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-28

Shanghai UCHEM Inc.

Product: 2-(Dicyclohexylphosphino)biphenyl 247940-06-3
Price: US $34.00-582.00/g
Min. Order: 25g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-25

XINXIANG RUNYU MATERIAL CO., LTD.

Product: 2-(Dicyclohexylphosphino)biphenyl 247940-06-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 500kg
Release date: 2021-11-29

247940-06-3, 2-(Dicyclohexylphosphino)biphenylRelated Search:

Tricyclohexyl phosphine Dicyclohexyl phthalate Biphenyl Dicyclohexylcarbodiimide 2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL 2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl CYCLOHEXYLPHOSPHINE DICYCLOHEXYLPHOSPHINE 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL X-PHOS 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-Dicyclohexylphosphino-2μ,4μ,6μ-triisopropylbiphenyl gold(I) bis(trifluoromethanesulfonyl)imide 2,2'-BIS(DICYCLOHEXYLPHOSPHINO)BIPHENYL 2'-DICYCLOHEXYLPHOSPHINO-2,6-DIMETHOXY-3-SULFONATO-1,1'-BIPHENYL HYDRATE SODIUM SALT (R)-(+)-2,2'-BIS(DICYCLOHEXYLPHOSPHINO)-1,1'-BINAPHTHYL 2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRIISO& 2-(Dicyclohexylphosphino)-2'-isopropylbiphenyl

CYCLOHEXYL JOHNPHOS

2-(DICYLOHEXYLPHOSPHINO)BIPHENYL

2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL

(2-BIPHENYLYL)DICYCLOHEXYLPHOSPHINE

2-(Dicyclohexylphosphino)biphenyl2-(Dicyclohexylphosphino)biphenyl

2-(Dicyclohexylphosphino)biphenyl,98%

(2-biphenyl)dicyclohexylphosphine

2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL 98%

dicyclohexyl-(2-phenylphenyl)phosphane

PHOSPHINE, [1,1''-BIPHENYL]-2-YLDICYCLOHEXYL-

2-(Dicyclohexylphosphino))-1,1'-biphenyl, 98% CyJohnPhos

2-(Dicyclohexyl)phosphine biphenyl

2-(Dicyclo

2-(Dicyclohexylphosphino)biphenyl, Cyclohexyl JohnPhos

2-(Dicyclohexylphosphino)biphenyl ,95%

(2-Biphenyl)dicyclohexylphosphine,2-(Dicyclohexylphosphino)biphenyl, Cyclohexyl JohnPhos

Cy-John-Phos

2-(Dicyclohexylphosphino)biphenyl, 98% 500MG

biphenyl-2-yldicyclohexylphosphine

2-(DicyclohexylphosphiNA)biphenyl

98% CyJohnPhos

2-dicyclohexylphosphino-1,1'-biphenyl

[1,1'-Biphenyl]-2-yldicyclohexylphosphine

2-(Dicyclohexylphosphino)biphe

2-(Dicyclohexylphosphino)biphenyl,98% CyJohnPhos

2-(Dicyclohexylphosphino)biphenyl CyJohnPhos

Dicyclohexylphosphino)bipheny

2-(Dicyclohexylphosphino)biphenyl, JohnPhos

2-(Dicyclohexylphosphino)biphenyl, 98% (Cyclohexyl JohnPhos)

CyJohnPhos 97%

2-(Dicyclohexylphosphino)biphenyl&gt

High purity CAS 247940-06-3 2-(Dicyclohexylphosphino)biphenyl in stock

CyJohnPhos CAS

2-(Dicyclohexylphosphino))-1,1'-biphenyl, 98%

Phosphine, [1,1'-biphenyl]-2-yldicyclohexyl-

CAS:247940-06-3

247940-06-3

C12H9PC6H112

C24H31P

Phosphorus Compounds

Catalysis and Inorganic Chemistry

Buchwald Ligands

Phosphine Ligands

Synthetic Organic Chemistry

organophosphine ligand

Ligand

Achiral Phosphine

Aryl Phosphine

Buchwald Ligands Series

Buchwald Ligands&Precatalysts

Phosphines