2-METHOXY-3-PYRIDINECARBOXALDEHYDE
- Product Name
- 2-METHOXY-3-PYRIDINECARBOXALDEHYDE
- CAS No.
- 71255-09-9
- Chemical Name
- 2-METHOXY-3-PYRIDINECARBOXALDEHYDE
- Synonyms
- 2-METHOXYNICOTINALDEHYDE;2-METHYOXYNICOTINALDEHYDE;2-Methoxypyridine-3-carba...;2-Methoxy-3-pyridinecarboxalde;2-Methoxy-3-pyridinecarbaldehyde;2-METHOXY-PYRIDINE-3-CARBALDEHYDE;2-Methoxypyridine-3-carboxaldehyde;2-METHOXY-3-PYRIDINECARBOXALDEHYDE;2-Methoxy-3-pyridinecaarboxaldehyde;2-Methoxy-3-pyridinecarboxaldenhyde
- CBNumber
- CB8329901
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 71255-09-9.mol
2-METHOXY-3-PYRIDINECARBOXALDEHYDE Property
- Boiling point:
- 200-201 °C (lit.)
- Density
- 1.161 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5500(lit.)
- Flash point:
- 205 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Liquid or Low Melting Solid
- pka
- 1.60±0.10(Predicted)
- color
- Colorless to yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C7H7NO2/c1-10-7-6(5-9)3-2-4-8-7/h2-5H,1H3
- InChIKey
- PIFFMIDNNWOQLK-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=CC=C1C=O
- CAS DataBase Reference
- 71255-09-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 41-43-36/37/38
- Safety Statements
- 26-36/37/39-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 632139
- Product name
- 2-Methoxy-3-pyridinecarboxaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $44
- Updated
- 2023/06/20
- Product number
- M218920
- Product name
- 2-Methoxy-3-pyridinecarboxaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 026108
- Product name
- 2-Methoxy-pyridine-3-carbaldehyde
- Packaging
- 500mg
- Price
- $19
- Updated
- 2021/12/16
- Product number
- F13069
- Product name
- 2-Methoxy-3-pyridinecarboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 4H15-1-18
- Product name
- 2-Methoxypyridine-3-carbaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $25
- Updated
- 2021/12/16
2-METHOXY-3-PYRIDINECARBOXALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Colorless to yellow liquid
Uses
2-Methoxy-3-pyridinecarboxaldehyde may be used to synthesize the following:
- ethyl 5-amino-4-(2-methoxy-3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylate, a potent AChE inhibitor
- N-hydroxy-2-pyridinone-based arylsulfone containing a Zn-binding group (ZBG) as MMP-2/-9 inhibitor
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 773, 1988 DOI: 10.1016/S0040-4039(00)80206-3
Synthesis
124-41-4
36404-88-3
71255-09-9
Sodium metal (0.35 g, 15.0 mmol) was slowly added to dry methanol (6 mL) at 0 °C and stirred until completely dissolved. Subsequently, a solution of anhydrous methanol (2 mL) of 2-chloro-3-pyridinecarboxaldehyde (0.708 g, 5.0 mmol) was added to the reaction system via syringe. The reaction mixture was heated to reflux temperature and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure. The residue was dissolved in water (10 mL), neutralized with dilute hydrochloric acid and extracted with ether (3 x 10 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (eluent: petroleum ether/ethyl acetate, 4:1) to afford the target compound 2-methoxy-3-pyridine aldehyde (0.473 g, 69% yield) as a colorless oil.1H NMR (300 MHz, CDCl3) δ 10.34 (d, J = 0.8 Hz, 1H), 8.36 (dd, J = 4.9, 2.1 Hz, 1H), 8.09 (dd, J = 7.4, 2.1 Hz, 1H), 7.00 (ddd, J = 7.4, 4.9, 0.8 Hz, 1H), 4.07 (s, 3H). 13C NMR (75 MHz, CDCl3) δ 189.1, 164.4, 152.8, 137.6, 118.8, 117.3, 54.0.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 9, p. 2409 - 2415
2-METHOXY-3-PYRIDINECARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHOXY-3-PYRIDINECARBOXALDEHYDE Suppliers
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View Lastest Price from 2-METHOXY-3-PYRIDINECARBOXALDEHYDE manufacturers
- Product
- 2-Methoxypyridine-3-carbaldehyde 71255-09-9
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 2-METHOXY-3-PYRIDINECARBOXALDEHYDE 71255-09-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-METHOXY-3-PYRIDINECARBOXALDEHYDE 71255-09-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14