ChemicalBook > CAS DataBase List > 2-METHOXY-3-PYRIDINECARBOXALDEHYDE

2-METHOXY-3-PYRIDINECARBOXALDEHYDE

Product Name
2-METHOXY-3-PYRIDINECARBOXALDEHYDE
CAS No.
71255-09-9
Chemical Name
2-METHOXY-3-PYRIDINECARBOXALDEHYDE
Synonyms
2-METHOXYNICOTINALDEHYDE;2-METHYOXYNICOTINALDEHYDE;2-Methoxypyridine-3-carba...;2-Methoxy-3-pyridinecarboxalde;2-Methoxy-3-pyridinecarbaldehyde;2-METHOXY-PYRIDINE-3-CARBALDEHYDE;2-Methoxypyridine-3-carboxaldehyde;2-METHOXY-3-PYRIDINECARBOXALDEHYDE;2-Methoxy-3-pyridinecaarboxaldehyde;2-Methoxy-3-pyridinecarboxaldenhyde
CBNumber
CB8329901
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
71255-09-9.mol
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2-METHOXY-3-PYRIDINECARBOXALDEHYDE Property

Boiling point:
200-201 °C (lit.)
Density 
1.161 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.5500(lit.)
Flash point:
205 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Liquid or Low Melting Solid
pka
1.60±0.10(Predicted)
color 
Colorless to yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H7NO2/c1-10-7-6(5-9)3-2-4-8-7/h2-5H,1H3
InChIKey
PIFFMIDNNWOQLK-UHFFFAOYSA-N
SMILES
C1(OC)=NC=CC=C1C=O
CAS DataBase Reference
71255-09-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
41-43-36/37/38
Safety Statements 
26-36/37/39-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
632139
Product name
2-Methoxy-3-pyridinecarboxaldehyde
Purity
96%
Packaging
1g
Price
$44
Updated
2023/06/20
TRC
Product number
M218920
Product name
2-Methoxy-3-pyridinecarboxaldehyde
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
026108
Product name
2-Methoxy-pyridine-3-carbaldehyde
Packaging
500mg
Price
$19
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
F13069
Product name
2-Methoxy-3-pyridinecarboxaldehyde
Purity
98%
Packaging
1g
Price
$19
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-18
Product name
2-Methoxypyridine-3-carbaldehyde
Purity
95%
Packaging
250mg
Price
$25
Updated
2021/12/16
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2-METHOXY-3-PYRIDINECARBOXALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless to yellow liquid

Uses

2-Methoxy-3-pyridinecarboxaldehyde may be used to synthesize the following:

  • ethyl 5-amino-4-(2-methoxy-3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylate, a potent AChE inhibitor
  • N-hydroxy-2-pyridinone-based arylsulfone containing a Zn-binding group (ZBG) as MMP-2/-9 inhibitor

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 773, 1988 DOI: 10.1016/S0040-4039(00)80206-3

Synthesis

124-41-4

36404-88-3

71255-09-9

Sodium metal (0.35 g, 15.0 mmol) was slowly added to dry methanol (6 mL) at 0 °C and stirred until completely dissolved. Subsequently, a solution of anhydrous methanol (2 mL) of 2-chloro-3-pyridinecarboxaldehyde (0.708 g, 5.0 mmol) was added to the reaction system via syringe. The reaction mixture was heated to reflux temperature and maintained for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure. The residue was dissolved in water (10 mL), neutralized with dilute hydrochloric acid and extracted with ether (3 x 10 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography (eluent: petroleum ether/ethyl acetate, 4:1) to afford the target compound 2-methoxy-3-pyridine aldehyde (0.473 g, 69% yield) as a colorless oil.1H NMR (300 MHz, CDCl3) δ 10.34 (d, J = 0.8 Hz, 1H), 8.36 (dd, J = 4.9, 2.1 Hz, 1H), 8.09 (dd, J = 7.4, 2.1 Hz, 1H), 7.00 (ddd, J = 7.4, 4.9, 0.8 Hz, 1H), 4.07 (s, 3H). 13C NMR (75 MHz, CDCl3) δ 189.1, 164.4, 152.8, 137.6, 118.8, 117.3, 54.0.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 9, p. 2409 - 2415

2-METHOXY-3-PYRIDINECARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Hexane Nitrogen tert-Butyllithium N,N-Dimethylformamide 2-Methoxypyridine Sodium chloride Sodium 2,4,6-Trimethybromombenzene Tetrahydrofuran Diethyl ether Ethyl acetate Sodium bicarbonate Acetic acid Magnesium sulfate

Preparation Products

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2-METHOXY-3-PYRIDINECARBOXALDEHYDE Suppliers

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View Lastest Price from 2-METHOXY-3-PYRIDINECARBOXALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Methoxypyridine-3-carbaldehyde 71255-09-9
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Dideu Industries Group Limited
Product
2-METHOXY-3-PYRIDINECARBOXALDEHYDE 71255-09-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-26
Career Henan Chemical Co
Product
2-METHOXY-3-PYRIDINECARBOXALDEHYDE 71255-09-9
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-14

71255-09-9, 2-METHOXY-3-PYRIDINECARBOXALDEHYDERelated Search:

2-PHENOXYBENZOYL CHLORIDE 1-AZAXANTHONE 2-(4-METHYLPHENOXY)NICOTINIC ACID 2-(4-CHLOROPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE 2-(4-CHLOROPHENOXY)NICOTINIC ACID 2,6-Dimethoxypyridine-3-carboxylic acid 2-Methoxynicotinic acid 2-PHENOXYNICOTINIC ACID 6-METHOXY-2-PYRIDINECARBOXALDEHYDE,2-METHOXY-6-PYRIDINECARBOXALDEHYDE 2-Methoxy-4-pyridinecarboxaldehyde 3-METHOXY-5-PYRIDINECARBOXALDEHYDE,5-METHOXY-3-PYRIDINECARBOXALDEHYDE 2-BROMO-3-METHOXY-4-PYRIDINECARBOXALDEHYDE 2-methoxy-5-pyridinecarboxaldehyde,6-Methoxy-3-pyridinecarboxaldehyde ,97%,6-METHOXY-3-PYRIDINECARBOXALDEHYDE 3-METHOXY-2-PYRIDINECARBOXALDEHYDE 3-Pyridinecarboxaldehyde 2-Methoxypyridine 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE 2-(4-METHYLPHENOXY)NICOTINAMIDE

  • 2-METHOXYNICOTINALDEHYDE
  • 2-METHOXY-PYRIDINE-3-CARBALDEHYDE
  • 2-METHOXY-3-PYRIDINECARBOXALDEHYDE
  • 3-Pyridinecarboxaldehyde, 2-methoxy- (9CI)
  • 2-Methoxy-3-pyridinecarboxaldenhyde
  • 2-Methoxy-3-pyridinecaarboxaldehyde
  • 2-METHYOXYNICOTINALDEHYDE
  • 2-Methoxypyridine-3-carboxaldehyde
  • 2-Methoxy-3-pyridinecarboxaldehyde ,98%
  • 2-Methoxy-3-pyridinecarboxaldehyde ,97.5%
  • 2-Methoxypyridine-3-carba...
  • 2-Methoxy-3-pyridinecarboxalde
  • 2-Methoxy-3-pyridinecarboxaldehyde 96%
  • 3-Pyridinecarboxaldehyde,2-methoxy-
  • 2-Methoxy-3-pyridinecarbaldehyde
  • 2-METHOXY-3-PYRIDINECARBOXALDEHYDE ISO 9001：2015 REACH
  • 71255-09-9
  • 71225-09-9
  • ALDEHYDE
  • C7 and C8
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridines
  • Heterocycle-Pyridine series
  • ALDEHYDE
  • C7 and C8
  • Heterocyclic Building Blocks
  • Pyridines