Repotrectinib

Binding Mode

Product Name: Repotrectinib
CAS No.: 1802220-02-5
Chemical Name: Repotrectinib
Synonyms: Repotrectinib;TPX-005;Ropotrectinib;CS-2479;TPX-0005;Loprotinib;PX0005(Ropotrectinib);TPX0005(Ropotrectinib);Repotrectinib,TPX-0005;TPX-0005,Repotrectinib
CBNumber: CB83312797
Molecular Formula: C18H18FN5O2
Formula Weight: 355.37
MOL File: 1802220-02-5.mol

More

Less

Repotrectinib Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM)
form: A crystalline solid
pka: 10.79±0.60(Predicted)
color: White to off-white
InChI: InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey: FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES: O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 23397
Product name: TPX-0005
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-7628
Product name: Repotrectinib
Purity: 99.81%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

More

Less

Repotrectinib Chemical Properties,Usage,Production

Binding Mode

The cocrystal structures of repotrectinib with TRK proteins are yet to be reported. However, a docking model with TRKA suggests that the pyrazole nitrogen forms hydrogen bonds with Met592 in the hinge area. The fluorophenyl group, positioned in a hydrophobic pocket, aligns perpendicularly to the macrocycle, and the lactam oxygen atom engages in a water-mediated hydrogen bond with Met592 in the hinge region (Figs. 1,2).

Description

Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].

Description

Repotrectinib, also known as TPX-0005, is a multikinase (ROS1, ALK, and TRKA/B/C) inhibitor that is tested in an ongoing first-in-human phase 1/2 trail (NCT03093116).

brand name

Augtyro

General Description

Class: receptor tyrosine kinase; Treatment: NSCLC; Other name: TPX-0005

Biological Activity

Repotrectinib is a potent inhibitor targeting solvent-front mutations (SFMs) of ROS1, pan-TRK, and ALK. It effectively inhibits the kinase activity of wild-type ROS1, TRKA-C, and ALK, along with their SFMs, with IC50 values ranging from 0.071 to 4.46 nM. The compound shows high potency against ROS1 and TRKA-C, with approximately 15-fold selectivity over ALK.

Clinical Use

Repotrectinib has advantage with central nervous system (CNS) penetration, aimed to target both wide-type (WT) and solvent-front mutations (SFM) kinases and other resistance mutations including ROS1-G2032R and ROS1-D2033N, TRKA-G595R, TRKB-G639R, TRKC-G623R, and ALK-G1202R.

Side effects

Common side effects of Repotrectinib include dizziness, taste disturbances, and abnormal sensations. Other possible side effects are: constipation, diarrhoea, tiredness, weakness or malaise; swelling of the face, eyes, arms, legs, hands or feet; weight gain; burning, tingling or numbness in the hands and feet. Severe can lead to breathing problems, muscle pain, pressure or weakness; vision changes, bone pain, difficulty moving or skeletal abnormalities.

target

Primary targets: NTRK, ROS, ALT

Repotrectinib Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Repotrectinib Suppliers

China 179 United States 9 Global 188

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

More

Less

View Lastest Price from Repotrectinib manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Repotrectinib 1802220-02-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-09-28

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Repotrectinib 1802220-02-5
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 50kg/Month
Release date: 2025-09-10

Jinan Million Pharmaceutical Co., Ltd

Product: Repotrectinib/TPX-0005 1802220-02-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50KG/M
Release date: 2023-08-14

1802220-02-5, RepotrectinibRelated Search:

TPX-0131 CSF1R-IN-2 17,19-Metheno-1H,5H-cyclopent[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one, 7-fluoro-2,3,3a,12,13,20a-hexahydro-11-methyl-, (3aS,11R,20aR)- TPX-0046 Entrectinib LOXO-195 LOXO-195 NVP-BKM120 (Hydrochloride) Crizotinib Lorlatinib (PF-06463922)

Ropotrectinib

TPX-0005;TPX 0005;TPX0005

CS-2479

Repotrectinib(TPX-005)

Repotrectinib

Repotrectinib,TPX-0005

TPX-0005

1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-

TPX-0005,Repotrectinib

TPX-005

TPX0005(Ropotrectinib)

Ropotrectinib(TPX0005)

Loprotinib

(7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one

PX0005(Ropotrectinib)

Repotrectinib, 10 mM in DMSO

1802220-02-5

180222-02-5

API

1802220-02-5