1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

ChemicalBook > CAS DataBase List > 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

Product Name: 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
CAS No.: 53554-29-3
Chemical Name: 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
Synonyms: BUTTPARK;AvafilImpurity32;BUTTPARK 21\07-73;RSYY(Apremilast)-4;Avanafil Impurity 86;1,4-Dihydro-2-(methylthio)-4-oxo-5;1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE;1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;4-hydroxy-2-methylthiopyrimidine-5-ethyl formate;Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
CBNumber: CB8337586
Molecular Formula: C8H10N2O3S
Formula Weight: 214.24
MOL File: 53554-29-3.mol

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1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Property

Melting point:: 136-144°C
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 6.48±0.50(Predicted)
CAS DataBase Reference: 53554-29-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S376523
Product name: ETHYL 4-HYDROXY-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

TRC

Product number: D492223
Product name: 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: D492223
Product name: 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 066838
Product name: Ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate
Purity: 84%
Packaging: 5g
Price: $121
Updated: 2021/12/16

Apolloscientific

Product number: OR0875
Product name: Ethyl1,4-dihydro-2-(methylthio)-4-oxopyrimidine-5-carboxylate
Packaging: 1g
Price: $15
Updated: 2021/12/16

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1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

1,4-Dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Methylthiourea sulfate (75.2g, 0.4mol) was added to 16% NaOH (250mL, 1.18mol) solution and stirred for 30min, then diethyl ethoxymethylenemalonate (103.4g, 0.48 mol) was dissolved in 160 mL of ethanol and slowly dropped into the reaction solution. After the dropwise addition was completed, the reaction was carried out at room temperature for 10 h.When a large amount of white solid was precipitated, carry out suction filtration, wash with water, and vacuum dry to obtain a white solid (84.7g, 99.7%); ESE-MS (m/z): 249[M+H]+, 236.9[M+Na]+ , after verification, the product is 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Potassium hydroxide Diethyl ethoxymethylenemalonate Triethyl orthoformate Sodium Phosphorus oxychloride Benzene 2-Methyl-2-thiopseudourea sulfate Diethyl malonate

Preparation Products

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1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Suppliers

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View Lastest Price from 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester 53554-29-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-12

TAIZHOU DKD CHEMICAL CO., LTD.

Product: 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 53554-29-3
Price: US $0.00/kg
Min. Order: 25kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2022-11-15

Henan Aochuang Chemical Co.,Ltd.

Product: 1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylateacidethylester 53554-29-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

53554-29-3, 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTERRelated Search:

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER ETHYL 5-PYRIMIDINECARBOXYLATE 98 ETHYL 2-(METHYLSULFANYL)-4-[3-(TRIFLUOROMETHYL)PHENOXY]-5-PYRIMIDINECARBOXYLATE Avanafil Impurity 9 Avanafil Impurity 19 Avanafil Impurity 24 4-(4-MethoxybenzylaMino)-5-ethoxycarbonyl-2-MethylthiopyriMidine Avanafil Impurity 10 Avanafil Impurity 16 Avanafil Impurity 26 1364671-52-2 5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- Avanafil iMpurity 5 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid Avanafil Impurity 23 Avanafil iMpurity 2 Avanafil Impurity 20 Avanafil Impurity 25

1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-

5-PyriMidinecarboxylicacid, 1,6-dihydro-2-(Methylthio)-6-oxo-, ethyl ester

Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate

Ethyl 2-(Methylthio)-6-oxo-1,6-dihydropyriMidine-5-carboxylate

1,4-dihydro-2-Methyl-4-oxo-5-Mercapto-pyriMidine-carboxylic acid ethyl ester

Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate

1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER >98%

5-PYRIMIDINECARBOXYLICACID,1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-,ETHYLESTER

ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

Ethyl 1,4-dihydro-2-(methylthio)-4-oxopyrimidine-5-carboxylate

Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate

Ethyl 1,4-dihydro-2-(methylsulphanyl)-4-oxopyrimidine-5-carboxylate, 1,4-Dihydro-5-(ethoxycarbonyl)-2-(methylthio)-4-oxopyrimidine

Ethyl 1,4-dihydro-2-(Methylthio)-4-oxo-5-pyriMidinecarboxylate

4-Hydroxy-2-Methylsulfanyl-pyriMidine-5-carboxylic acid ethyl ester

BUTTPARK

4-hydroxy-2-methylthiopyrimidine-5-ethyl formate

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

BUTTPARK 21\07-73

Methyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

Avanafil Impurity 86

Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carbo...

1,4-Dihydro-2-(methylthio)-4-oxo-5

Ethyl 2-thiomethyl-4-hydroxypyrimidine-5-carboxylate

AvafilImpurity32

1,4-DHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE

RSYY(Apremilast)-4

Ethyl 1,6-dihydro-2-(methylthio)-6-oxo-5-pyrimidinecarboxylate

53554-29-3

pyrimidine