ChemicalBook > CAS DataBase List > 2,3-Difluorophenylboronic acid

2,3-Difluorophenylboronic acid

Product Name: 2,3-Difluorophenylboronic acid
CAS No.: 121219-16-7
Chemical Name: 2,3-Difluorophenylboronic acid
Synonyms: 2,3-Difl;RARECHEM AH PB 0166;2,3-Difluorophenylbo;Difluorophenylboronic aci;2,3-difluorobenzorbic acid;2,3-DIFLUOROPHENYLBORONIC ACID;2,3-FLUOROBENZENE BORONIC ACID;2,3-Dilfuorophenylboronic acid;2,3-DIFLUOROBENZENEBORONIC ACID;2,3-Difluorobenzeneboronicacid98%
CBNumber: CB8351070
Molecular Formula: C6H5BF2O2
Formula Weight: 157.91
MOL File: 121219-16-7.mol

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2,3-Difluorophenylboronic acid Property

Melting point:: 95 °C (dec.) (lit.)
Boiling point:: 274.8±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 7.29±0.58(Predicted)
form: Crystalline Powder
color: White to light beige
BRN: 6594341
InChI: InChI=1S/C6H5BF2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H
InChIKey: SZYXKFKWFYUOGZ-UHFFFAOYSA-N
SMILES: B(C1=CC=CC(F)=C1F)(O)O
CAS DataBase Reference: 121219-16-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 514039
Product name: 2,3-Difluorophenylboronic acid
Packaging: 5g
Price: $42.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 514039
Product name: 2,3-Difluorophenylboronic acid
Packaging: 25g
Price: $183
Updated: 2023/06/20

TCI Chemical

Product number: D3523
Product name: 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: D3523
Product name: 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $117
Updated: 2025/07/31

TRC

Product number: D450913
Product name: 2,3-Difluorophenylboronic acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2,3-Difluorophenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white to light beige crystalline powder

Uses

suzuki reaction

Uses

2,3-Difluorophenylboronic acid is a useful reagent for the preparation of pharmaceutical and biologically active molecules.

Uses

Intermediates of Liquid Crystals

Synthesis

688-71-1

367-11-3

121219-16-7

The general procedure for the synthesis of 2,3-difluorophenylboronic acid from tri-n-propyl borate and 1,2-difluorobenzene is as follows: in a 1L three-necked flask equipped with a mechanical stirrer, nitrogen inlet and outlet, pressure-balancing dropping funnel, and a thermometer, 1,2-difluorobenzene (40 g, 0.35 mol) and anhydrous tetrahydrofuran (400 ml) were added. Nitrogen was introduced to displace the air in the reaction system and a weak flow of nitrogen was maintained throughout the reaction. The reaction mixture was cooled to -78 °C using a dry ice/acetone bath, followed by the slow dropwise addition of 2.5 mol/L hexane solution of n-butyllithium (140 ml, 0.35 mol) through a dropping funnel, controlling the reaction temperature to not exceed -70 °C. After the dropwise addition of n-butyllithium solution was completed, the reaction mixture was continued to be stirred at -78 °C for 2 hours. Subsequently, tri-n-propyl borate (66 g, 0.35 mol) was added dropwise, again keeping the reaction temperature below -70 °C. After the addition of tri-n-propyl borate, the cooling bath was withdrawn and the reaction mixture was allowed to warm up naturally to room temperature with continuous stirring. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a viscous liquid residue. The residue was acidified and the resulting propanol was subsequently evaporated. The precipitated solid product was collected by filtration, washed with hexane and purified by aqueous recrystallization to give a final white crystalline 2,3-difluorophenylboronic acid 47 g in 85% of theoretical yield.

References

[1] Patent: US2013/20532, 2013, A1. Location in patent: Paragraph 0042
[2] Journal of Materials Chemistry C, 2014, vol. 2, # 5, p. 891 - 900

2,3-Difluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Triisopropyl borate 1,2-Difluorobenzene n-Butyllithium

Preparation Products

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2,3-Difluorophenylboronic acid Suppliers

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View Lastest Price from 2,3-Difluorophenylboronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,3-Difluorophenylboronic acid 121219-16-7
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-06-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2,3-Difluorophenylboronic acid 121219-16-7
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-21

Anhui Ruihan Technology Co., Ltd

Product: 2,3-Difluorophenylboronic acid 121219-16-7
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000t/year
Release date: 2023-09-07

121219-16-7, 2,3-Difluorophenylboronic acidRelated Search:

2,4-Difluorobenzoic acid 1,3-Difluorobenzene Ethyl 2-(Chlorosulfonyl)acetate Folic acid 4-Fluorobenzeneboronic acid Phenylboronic acid 1,2-Difluorobenzene Citric acid Ascoric Acid 2,3,6-Trifluorophenylboronic acid 2,3,4-Trifluorophenylboronic acid 2,3-Difluoro-6-methoxyphenylboronic acid 2 3-DIFLUORO-4-FORMYPHENYLBORONIC ACID 2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID 2,4-Dinitrofluorobenzene 2,3,4,5-TETRAFLUOROBENZENEBORONIC ACID 2,3,4,6-TETRAFLUOROBENZENEBORONIC ACID 2,3,5-Trifluorophenylboronic acid

2,3-Difluorophenylboronic acid, 97%, May contain varying aMounts of anhydride

Difluorophenylboronic aci

2,3-Difl

RARECHEM AH PB 0166

2,3-DIFLUOROPHENYLBORONIC ACID

2,3-DIFLUOROBENZENEBORONIC ACID

2,3-FLUOROBENZENE BORONIC ACID

2,3-Difluorophenylboronic acid, 97+%

2,3-Difluorobenzeneboronic acid 98%

2,3-Difluorobenzeneboronicacid98%

2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)

2,3-Dilfuorophenylboronic acid

2,3-Difluorophenylboronic acid ,98%

2,3-Difluorophenylbo

2,3-Difluorophenylboronic acid, May contain varying amounts of anhydride, 97%

Boronic acid, B-(2,3-difluorophenyl)-

2,3-difluorobenzorbic acid

2,3-Difluorophenylboronic acid - [D2600]

121219-16-7

121219-16-9

BORONIC ACID

Boronic Acids

Boronic Acids and Derivatives

Aryl

Organometallic Reagents

Boronate Ester

Potassium Trifluoroborate

B (Classes of Boron Compounds)

Boronic Acids

Boronic Acids and Derivatives

Aryl

Halogenated

Organoborons

blocks

BoronicAcids

FluoroCompounds

Boric Acid

Fluorobenzene

Boronic Acid