2,3-Difluorophenylboronic acid
- Product Name
- 2,3-Difluorophenylboronic acid
- CAS No.
- 121219-16-7
- Chemical Name
- 2,3-Difluorophenylboronic acid
- Synonyms
- 2,3-Difl;RARECHEM AH PB 0166;2,3-Difluorophenylbo;Difluorophenylboronic aci;2,3-difluorobenzorbic acid;2,3-DIFLUOROPHENYLBORONIC ACID;2,3-FLUOROBENZENE BORONIC ACID;2,3-Dilfuorophenylboronic acid;2,3-DIFLUOROBENZENEBORONIC ACID;2,3-Difluorobenzeneboronicacid98%
- CBNumber
- CB8351070
- Molecular Formula
- C6H5BF2O2
- Formula Weight
- 157.91
- MOL File
- 121219-16-7.mol
2,3-Difluorophenylboronic acid Property
- Melting point:
- 95 °C (dec.) (lit.)
- Boiling point:
- 274.8±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 7.29±0.58(Predicted)
- form
- Crystalline Powder
- color
- White to light beige
- BRN
- 6594341
- InChI
- InChI=1S/C6H5BF2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H
- InChIKey
- SZYXKFKWFYUOGZ-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC(F)=C1F)(O)O
- CAS DataBase Reference
- 121219-16-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 514039
- Product name
- 2,3-Difluorophenylboronic acid
- Packaging
- 5g
- Price
- $42.2
- Updated
- 2023/06/20
- Product number
- 514039
- Product name
- 2,3-Difluorophenylboronic acid
- Packaging
- 25g
- Price
- $183
- Updated
- 2023/06/20
- Product number
- D3523
- Product name
- 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- D3523
- Product name
- 2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $117
- Updated
- 2025/07/31
- Product number
- 273445
- Product name
- 2,3-Difluorophenylboronic acid
- Packaging
- 10g
- Price
- $365
- Updated
- 2021/12/16
2,3-Difluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white to light beige crystalline powder
Uses
suzuki reaction
Uses
2,3-Difluorophenylboronic acid is a useful reagent for the preparation of pharmaceutical and biologically active molecules.
Uses
Intermediates of Liquid Crystals
Synthesis
688-71-1
367-11-3
121219-16-7
The general procedure for the synthesis of 2,3-difluorophenylboronic acid from tri-n-propyl borate and 1,2-difluorobenzene is as follows: in a 1L three-necked flask equipped with a mechanical stirrer, nitrogen inlet and outlet, pressure-balancing dropping funnel, and a thermometer, 1,2-difluorobenzene (40 g, 0.35 mol) and anhydrous tetrahydrofuran (400 ml) were added. Nitrogen was introduced to displace the air in the reaction system and a weak flow of nitrogen was maintained throughout the reaction. The reaction mixture was cooled to -78 °C using a dry ice/acetone bath, followed by the slow dropwise addition of 2.5 mol/L hexane solution of n-butyllithium (140 ml, 0.35 mol) through a dropping funnel, controlling the reaction temperature to not exceed -70 °C. After the dropwise addition of n-butyllithium solution was completed, the reaction mixture was continued to be stirred at -78 °C for 2 hours. Subsequently, tri-n-propyl borate (66 g, 0.35 mol) was added dropwise, again keeping the reaction temperature below -70 °C. After the addition of tri-n-propyl borate, the cooling bath was withdrawn and the reaction mixture was allowed to warm up naturally to room temperature with continuous stirring. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give a viscous liquid residue. The residue was acidified and the resulting propanol was subsequently evaporated. The precipitated solid product was collected by filtration, washed with hexane and purified by aqueous recrystallization to give a final white crystalline 2,3-difluorophenylboronic acid 47 g in 85% of theoretical yield.
References
[1] Patent: US2013/20532, 2013, A1. Location in patent: Paragraph 0042
[2] Journal of Materials Chemistry C, 2014, vol. 2, # 5, p. 891 - 900
2,3-Difluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Difluorophenylboronic acid Suppliers
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View Lastest Price from 2,3-Difluorophenylboronic acid manufacturers
- Product
- 2,3-Difluorophenylboronic acid 121219-16-7
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-06-13
- Product
- 2,3-Difluorophenylboronic acid 121219-16-7
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21
- Product
- 2,3-Difluorophenylboronic acid 121219-16-7
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000t/year
- Release date
- 2023-09-07