ChemicalBook > CAS DataBase List > 6-Nitroindazole

6-Nitroindazole

Product Name
6-Nitroindazole
CAS No.
7597-18-4
Chemical Name
6-Nitroindazole
Synonyms
6-NITRO-1H-INDAZOLE;6-Nitrobrazol;6-NITROINDAZOLE;6-Nitroindazoles;6-Nitroisoindazole;6-nitro-1h-indazol;6-Nitroindazole>6-Nitroindazole 97%;6-Nitroindazole,98%;6-Nitroindazole ,97%
CBNumber
CB8358413
Molecular Formula
C7H5N3O2
Formula Weight
163.13
MOL File
7597-18-4.mol
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6-Nitroindazole Property

Melting point:
180-182 °C (lit.)
Boiling point:
290.19°C (rough estimate)
Density 
1.4141 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
very faint turbidity in hot Methanol
pka
11.08±0.40(Predicted)
form 
Powder
color 
Light Yellow
BRN 
7812
CAS DataBase Reference
7597-18-4(CAS DataBase Reference)
NIST Chemistry Reference
6-Nitroindazole(7597-18-4)
EPA Substance Registry System
1H-Indazole, 6-nitro- (7597-18-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38-40-68-36
Safety Statements 
26-27-36/37/39
WGK Germany 
3
RTECS 
NK7962100
TSCA 
Yes
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N17513
Product name
6-Nitroindazole
Purity
97%
Packaging
100g
Price
$254
Updated
2023/06/20
TCI Chemical
Product number
N0399
Product name
6-Nitroindazole
Purity
>98.0%(GC)
Packaging
25g
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
N0399
Product name
6-Nitroindazole
Purity
>98.0%(GC)
Packaging
250g
Price
$167
Updated
2024/03/01
Alfa Aesar
Product number
A16213
Product name
6-Nitro-1H-indazole, 97%
Packaging
100g
Price
$88
Updated
2021/12/16
Alfa Aesar
Product number
A16213
Product name
6-Nitro-1H-indazole, 97%
Packaging
25g
Price
$35.8
Updated
2021/12/16
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6-Nitroindazole Chemical Properties,Usage,Production

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].

Chemical Properties

yellow powder

Uses

Anticonvulsant.

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated  acetonitrile.

References

[1] HERRAIZTOMAS  GuillénHugo  AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

6-Nitroindazole Preparation Products And Raw materials

Raw materials

Sodium nitrite 2-Methyl-5-nitroaniline Acetic acid

Preparation Products

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6-Nitroindazole Suppliers

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View Lastest Price from 6-Nitroindazole manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-Nitroindazole 7597-18-4
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Nanjing Fred Technology Co., Ltd
Product
6-Nitroindazole 7597-18-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-27
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
6-Nitro-1H-indazole 7597-18-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-01-05

7597-18-4, 6-NitroindazoleRelated Search:

3-Methyl-6-nitroindazole 3-Nitroacetophenone Sodium 3-nitrobenzenesulphonate 2-Ethyl-5-nitrobenzenamine ,98% 5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine Pazopanib Impurity 48 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32 2,4-Dichloropyrimidine Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl- 1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- Pazopanib Impurity 47

  • 1H-Indazole, 6-nitro-
  • 6-nitro-1h-indazol
  • 6-Nitroisoindazole
  • 6-NITRO-1H-INDAZOLE
  • 6-NITROINDAZOLE
  • 6-Nitro-1(2)H-indazole
  • 6-Nitroindazole ,97%
  • 6-Nitroindazole,98%
  • 6-Nitroindazoles
  • 6-Nitro-1H-indazole,97%
  • 6-Nitroindazole 97%
  • 6-Nitroindazole&gt
  • 6-Nitrobrazol
  • Pazopanib Impurity 59
  • 7597-18-4
  • 9597-18-4
  • Building Blocks
  • Heterocyclic Building Blocks
  • Indazoles
  • Inhibitors
  • Nitric Oxide Reagents
  • Building Blocks
  • Heterocyclic Building Blocks
  • Heterocyclic Compounds
  • All Inhibitors
  • Indazoles
  • Intermediate